Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)
Evo 2 7B base model scoring a variant as the log-likelihood of the alternative minus the reference 8,192 bp sequence.
14 evaluations · 14 results1 open disagreement between studies involves its model
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
14 evaluations · 14 results. Different protocols are not a single leaderboard.
Protocol: ClinVar pathogenic versus benign SNVs within variant type, AUROC (Lu et al. 2025)
Sorted by AUROC (ClinVar pathogenic vs benign SNVs, 3' UTR) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Protocol and dataset | AUROC (ClinVar pathogenic vs benign SNVs, 3' UTR) | AUROC (ClinVar pathogenic vs benign SNVs, 5' UTR) | AUROC (ClinVar pathogenic vs benign SNVs, All variants) | AUROC (ClinVar pathogenic vs benign SNVs, Intron (Non-splice)) | AUROC (ClinVar pathogenic vs benign SNVs, Missense & 3'UTR) | AUROC (ClinVar pathogenic vs benign SNVs, Missense & Intron (Non-splice)) | AUROC (ClinVar pathogenic vs benign SNVs, Missense) | AUROC (ClinVar pathogenic vs benign SNVs, Noncoding) | AUROC (ClinVar pathogenic vs benign SNVs, RNA gene) | AUROC (ClinVar pathogenic vs benign SNVs, Splice) | AUROC (ClinVar pathogenic vs benign SNVs, Start loss) | AUROC (ClinVar pathogenic vs benign SNVs, Stop gain) | AUROC (ClinVar pathogenic vs benign SNVs, Stop loss) | AUROC (ClinVar pathogenic vs benign SNVs, Synonymous) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: 3' UTR (Figure 1) | 0.747 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: All variants (Figure 1) | Not reported | Not reported | 0.969 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Intron (Non-splice) (Figure 1) | Not reported | Not reported | Not reported | 0.903 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Missense & Intron (Non-splice) (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | 0.835 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Missense & 3'UTR (Figure 1) | Not reported | Not reported | Not reported | Not reported | 0.896 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Missense (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.836 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Noncoding (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.975 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: RNA gene (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.459 | Not reported | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Splice (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.697 | Not reported | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Start loss (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.711 | Not reported | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Stop gain (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.663 | Not reported | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Stop loss (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.826 | Not reported |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: Synonymous (Figure 1) | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | 0.885 |
| Evo 2 7B base, 8,192 bp log-likelihood ratio (Lu et al. 2025)Evaluation | Lu et al. 2025 ClinVar benchmark: 5' UTR (Figure 1) | Not reported | 0.767 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- Genomic heterogeneity inflates the performance of variant pathogenicity predictions (Lu, Liu, Lin and Brandes, bioRxiv 2025, v2) · Original source · bioRxiv preprint version 2, posted 2025-09-10 (version 1 posted 2025-09-08); full-text PDF (21 pages)
Technical metadata and extraction receipts
Stable ID: lu-hetero-20261019-config-evo2-7b-base-llr
- areas
- dna-genomes
- contexts
- clinical_research
- method types
- foundation_model
- reported name
- Evo2
- parameters
- evo2_7b_base from the Evo2 GitHub repository; 8,192 bp centred window; model.score_sequences on reference and alternative; score multiplied by -1.
- source locator
- Methods 'Evo2' (pages 13 to 14)
Related records
- configuration of: Evo 2
- system: Evo2 on ClinVar All variants SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Intron (Non-splice) SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Missense & Intron (Non-splice) SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Missense & 3'UTR SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Missense SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Noncoding SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar RNA gene SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Splice SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Start loss SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Stop gain SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Stop loss SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar Synonymous SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar 3' UTR SNVs (Lu et al. 2025 Figure 1)
- system: Evo2 on ClinVar 5' UTR SNVs (Lu et al. 2025 Figure 1)