GPN-MSA_Embeddings.plus.euclidean_distance (TraitGym)
GPN-MSA scored as 'Euclidean distance of embeddings' in TraitGym.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Sorted by AUPRC (weighted average over chromosomes of per-chromosome AUPRC; subset 'all') (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
| Tested configuration | Protocol and dataset | AUPRC (weighted average over chromosomes of per-chromosome AUPRC; subset 'all') |
|---|---|---|
| GPN-MSA_Embeddings.plus.euclidean_distance (TraitGym)Evaluation | TraitGym Mendelian traits, zero-shot, AUPRC by chromosome weighted average, TraitGym Mendelian traits, matched 9 controls | 0.207 (best in column) |
| GPN-MSA_Embeddings.plus.euclidean_distance (TraitGym)Evaluation | TraitGym Complex traits, zero-shot, AUPRC by chromosome weighted average, TraitGym Complex traits, matched 9 controls | 0.15 |
All 2 result rows with coverage, uncertainty and sources
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: GPN-MSA_Embeddings.plus.euclidean_distance (TraitGym) | Protocol: TraitGym Complex traits, zero-shot, AUPRC by chromosome weighted average Dataset: TraitGym Complex traits, matched 9 controls | 0.15 AUPRC (weighted average over chromosomes of per-chromosome AUPRC; subset 'all') unitless · higher Uncertainty: SE 0.006486413285701392 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceGPN-MSA_Embeddings.plus.euclidean_distance on TraitGym complex_traits_matched_9 lit-genomics-20261011-traitgym-protocol-complex-traits-matched-9-zero-shot Aggregation: Not reported TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) · complex_traits_matched_9/AUPRC_by_chrom_weighted_average/all/GPN-MSA_Embeddings.plus.euclidean_distance.csv, column 'score' (standard error in column 'se') |
| Configuration: GPN-MSA_Embeddings.plus.euclidean_distance (TraitGym) | Protocol: TraitGym Mendelian traits, zero-shot, AUPRC by chromosome weighted average Dataset: TraitGym Mendelian traits, matched 9 controls | 0.207 AUPRC (weighted average over chromosomes of per-chromosome AUPRC; subset 'all') unitless · higher Uncertainty: SE 0.020884292254464948 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceGPN-MSA_Embeddings.plus.euclidean_distance on TraitGym mendelian_traits_matched_9 lit-genomics-20261011-traitgym-protocol-mendelian-traits-matched-9-zero-shot Aggregation: Not reported TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) · mendelian_traits_matched_9/AUPRC_by_chrom_weighted_average/all/GPN-MSA_Embeddings.plus.euclidean_distance.csv, column 'score' (standard error in column 'se') |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
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How it works, versions and access
Related profile: GPN-MSA. This page retains the exact record and its evaluation context.
Strengths, limitations and unresolved questions
Evidence
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Evidence table
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2 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Relationship: configuration of gfm-guides-20261014-gpnmsa-model-gpn-msa Individual claims | GPN-MSA: an alignment-based DNA language model for genome-wide variant effect prediction (bioRxiv v2) Configuration name as printed in its source (GPN-MSA_Embeddings.plus.euclidean_distance); GPN-MSA identity from gfm-guides-20261014-gpnmsa-source-biorxiv-v2 (Abstract) and gfm-guides-20261014-gpnmsa-source-gpn-msa-doc Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bioRxiv v2, posted 2024-04-06 | source checked ["scope-review"] · 2026-10-14 Audit detailsAccepted in the independent review of 2026-10-14. See docs/reviews/2026-10-14-gfm-guide-evidence-review.md. Field: Claim: identity-20261014-84f95440aeb0af6d6bb3 Source artifact SHA-256: Hash scope: SHA-256 of the PDF bytes as downloaded 2026-10-14T12:02:16Z. bioRxiv rewrites the XMP dates and document IDs, the Info ModDate and the trailer /ID on download, so a re-download does not reproduce the hash; the review found a fresh copy of the same length differing only in those 51 bytes, with an identical pdftotext -layout text layer. |
| Relationship: configuration of gfm-guides-20261014-gpnmsa-model-gpn-msa Individual claims | TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) Configuration name as printed in its source (GPN-MSA_Embeddings.plus.euclidean_distance); GPN-MSA identity from gfm-guides-20261014-gpnmsa-source-biorxiv-v2 (Abstract) and gfm-guides-20261014-gpnmsa-source-gpn-msa-doc Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/ | source checked ["scope-review"] · 2026-10-14 Audit detailsAccepted in the independent review of 2026-10-14. See docs/reviews/2026-10-14-gfm-guide-evidence-review.md. Field: Claim: identity-20261014-84f95440aeb0af6d6bb3 Source artifact SHA-256: Hash scope: SHA-256 of a JSON bundle listing every retrieved CSV with its path, its own SHA-256 and its bytes (artifacts/traitgym-metrics-bundle.json.gz) |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- TraitGym official metrics: AUPRC by chromosome, weighted average (Hugging Face dataset songlab/TraitGym) · Original source · Hugging Face dataset revision 1fde19555fe8c0a55b1382bdf4c6f7082209f566 (last modified 2025-03-25); 156 metric CSVs under {dataset}/AUPRC_by_chrom_weighted_average/all/
Technical metadata and extraction receipts
Stable ID: lit-genomics-20261011-traitgym-config-gpn-msa-embeddings-plus-euclidean-distance
- areas
- dna-genomes
- contexts
- research
- method types
- foundation_model
- reported name
- GPN-MSA_Embeddings.plus.euclidean_distance
- foundation model eligible
- true
- parameters
- songlab/gpn-msa-sapiens; Euclidean distance of embeddings
- access reuse
- Public weights or score files (paper Appendix B.1)
- source locator
- File name 'GPN-MSA_Embeddings.plus.euclidean_distance.csv'; config/models.csv; paper Table S5
- version
- songlab/gpn-msa-sapiens