Configuration

GPN-MSA (zero-shot, GUANinE v1.1)

GPN-MSA: Regime M (MSA-based method); evaluation zero-shot.

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1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: GPN-MSA (zero-shot, GUANinE v1.1)	Protocol: GUANinE v1.1 cadd-snv, Spearman rho x100 (Table 3) Dataset: GUANinE cadd-snv test set	29.1 Spearman (GUANinE v1.1 test set) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPN-MSA on GUANinE cadd-snv lit-genomics-20261011-guanine-protocol-cadd-snv Aggregation: Not reported GUANinE v1.1 reveals complementarity of supervised and genomic language models · Table 3, row 'GPN-MSA', column 'cadd-snv' (ρ)

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

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2 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Relationship: configuration of gfm-guides-20261014-gpnmsa-model-gpn-msa Individual claims	GPN-MSA: an alignment-based DNA language model for genome-wide variant effect prediction (bioRxiv v2) Original source ↗ Configuration name as printed in its source (GPN-MSA); GPN-MSA identity from gfm-guides-20261014-gpnmsa-source-biorxiv-v2 (Abstract) and gfm-guides-20261014-gpnmsa-source-gpn-msa-doc Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bioRxiv v2, posted 2024-04-06 Retrieved: 2026-10-14T12:02:16Z	source checked ["scope-review"] · 2026-10-14 Audit details Accepted in the independent review of 2026-10-14. See docs/reviews/2026-10-14-gfm-guide-evidence-review.md. Field: `links:configuration_of:gfm-guides-20261014-gpnmsa-model-gpn-msa` Claim: identity-20261014-64fb7ea60841d206745e Source artifact SHA-256: `10411077df1ae59614f9a9a9f85384103d54127ba67a9b3c469a4a2d6c33cee4` Hash scope: SHA-256 of the PDF bytes as downloaded 2026-10-14T12:02:16Z. bioRxiv rewrites the XMP dates and document IDs, the Info ModDate and the trailer /ID on download, so a re-download does not reproduce the hash; the review found a fresh copy of the same length differing only in those 51 bytes, with an identical pdftotext -layout text layer. Inspected artifact
Relationship: configuration of gfm-guides-20261014-gpnmsa-model-gpn-msa Individual claims	GUANinE v1.1 reveals complementarity of supervised and genomic language models Original source ↗ Configuration name as printed in its source (GPN-MSA); GPN-MSA identity from gfm-guides-20261014-gpnmsa-source-biorxiv-v2 (Abstract) and gfm-guides-20261014-gpnmsa-source-gpn-msa-doc Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Bioinformatics 2026, btag427 (issue date 2026-08-01); PMC13501288 full-text XML Retrieved: 2026-10-11T00:40:24Z	source checked ["scope-review"] · 2026-10-14 Audit details Accepted in the independent review of 2026-10-14. See docs/reviews/2026-10-14-gfm-guide-evidence-review.md. Field: `links:configuration_of:gfm-guides-20261014-gpnmsa-model-gpn-msa` Claim: identity-20261014-64fb7ea60841d206745e Source artifact SHA-256: `f6cc4294a1519fb5579eebb29ffd919afad0198a3bf8b751635d73b17b33ef79` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

GUANinE v1.1 reveals complementarity of supervised and genomic language models · Original source · Bioinformatics 2026, btag427 (issue date 2026-08-01); PMC13501288 full-text XML

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Technical metadata and extraction receipts

Stable ID: lit-genomics-20261011-guanine-config-gpn-msa-zs

areas: dna-genomes
contexts: research
method types: conventional_pipeline
reported name: GPN-MSA
foundation model eligible: true
parameters: Regime M (MSA-based method); evaluation zero-shot; context column ''
source locator: Table 3 row 'GPN-MSA', columns Reg., Eval. and Context
access reuse: Not stated in the source; see the model's own release
missing metadata: version: reason: unreported; note: Only the printed row label identifies the checkpoint
model identity note: GPN-MSA, the multiple-sequence-alignment member of the GPN family
provenance note: GPN-MSA as evaluated in GUANinE v1.1.

Related records

configuration of: GPN-MSA
subject: GPN-MSA (zero-shot, GUANinE v1.1): configuration of GPN-MSA
system: GPN-MSA on GUANinE cadd-snv

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