Configuration

iNMF (SCMBench)

Evidence concern: excluded from comparisons

Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H

'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows

In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20

Configuration of iNMF: default or tuned hyperparameters per the SCMBench setup; Defaults for R methods and methods without explicit hyperparameters; tuned otherwise.

13 evaluations · 13 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

13 evaluations · 13 results. Different protocols are not a single leaderboard.

Sorted by Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI)	Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI; mean across datasets)
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Muto-2021-batch-4 (SCMBench)	0.415 (best in column)	Not reported
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Yao (SCMBench)	0.352	Not reported
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Muto-2021-batch-2 (SCMBench)	0.32	Not reported
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Muto-2021-batch-3 (SCMBench)	0.302	Not reported
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Muto-2021-batch-1 (SCMBench)	0.244	Not reported
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, Muto-2021-batch-5 (SCMBench)	0.221	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, 10x-Multiome-Pbmc10k (SCMBench)	0.203	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, Ma-2020-batch-53 (SCMBench)	0.177	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, Chen-2019 (SCMBench)	0.162	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, Ma-2020-batch-54 (SCMBench)	0.147	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, Ma-2020-batch-55 (SCMBench)	0.137	Not reported
iNMF (SCMBench)Evaluation	SCMBench paired RNA-ATAC integration accuracy, paired-overall (SCMBench)	Not reported	0.165
iNMF (SCMBench)Evaluation	SCMBench unpaired RNA-ATAC integration accuracy, unpaired-overall (SCMBench)	Not reported	0.309 (best in column)

All 13 result rows with coverage, uncertainty and sources

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: 10x-Multiome-Pbmc10k (SCMBench)	0.203 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, 10x-Multiome-Pbmc10k lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell B21 (row 'iNMF', column '10x-Multiome-Pbmc10k')
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: Chen-2019 (SCMBench)	0.162 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, Chen-2019 lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell C21 (row 'iNMF', column 'Chen-2019')
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: Ma-2020-batch-53 (SCMBench)	0.177 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, Ma-2020-batch-53 lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell D21 (row 'iNMF', column 'Ma-2020-batch-53')
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: Ma-2020-batch-54 (SCMBench)	0.147 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, Ma-2020-batch-54 lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell E21 (row 'iNMF', column 'Ma-2020-batch-54')
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: Ma-2020-batch-55 (SCMBench)	0.137 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, Ma-2020-batch-55 lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell F21 (row 'iNMF', column 'Ma-2020-batch-55')
Configuration: iNMF (SCMBench)	Protocol: SCMBench paired RNA-ATAC integration accuracy Dataset subset: paired-overall (SCMBench)	0.165 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI; mean across datasets) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench paired integration, paired-overall lit-cells-networks-20261011-scmbench-protocol-paired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G21 (row 'iNMF', column 'Overall')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Muto-2021-batch-1 (SCMBench)	0.244 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Muto-2021-batch-1 lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell C16 (row 'iNMF', column 'Muto-2021-batch-1')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Muto-2021-batch-2 (SCMBench)	0.32 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Muto-2021-batch-2 lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell D16 (row 'iNMF', column 'Muto-2021-batch-2')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Muto-2021-batch-3 (SCMBench)	0.302 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Muto-2021-batch-3 lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell E16 (row 'iNMF', column 'Muto-2021-batch-3')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Muto-2021-batch-4 (SCMBench)	0.415 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Muto-2021-batch-4 lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell F16 (row 'iNMF', column 'Muto-2021-batch-4')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Muto-2021-batch-5 (SCMBench)	0.221 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Muto-2021-batch-5 lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell G16 (row 'iNMF', column 'Muto-2021-batch-5')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: unpaired-overall (SCMBench)	0.309 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI; mean across datasets) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, unpaired-overall lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell H16 (row 'iNMF', column 'unlabelled column H')
Configuration: iNMF (SCMBench)	Protocol: SCMBench unpaired RNA-ATAC integration accuracy Dataset subset: Yao (SCMBench)	0.352 Scmbench integration accuracy (mean of MAP, NMI, ASW and ARI) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Evidence concern: excluded from comparisons Sheet 'unpaired_inte_overall' has no header for column H. Each H cell is the formula =AVERAGE(Bn:Gn), the mean of the dataset cells with values. Rows with a blank Yao cell (bindSC, scMoMaT, scGPT_zero, Pamona, scFoundation, Geneformer) average five datasets and the other rows six, so column H values are not comparable across all rows.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', row 1 and column H 'FM-scVI' is a different foundation model per dataset ('the best-performing foundation model combined with scVI, which varies across datasets', Fig. 2 legend), so its rows do not describe one fixed configuration.SCMBench Supplementary Data 2 (integration results) · Article Fig. 2 legend; Supplementary Data 2 'FM-scVI' rows In sheet 'paired_inte_overall' the scGPT row is scored on 10x-Multiome-Pbmc10k only; its Overall cell G20 (=AVERAGE(B20:F20)) is that single value, not a five-dataset mean, so it is not comparable with the other Overall values.SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'paired_inte_overall', cell G20 Methods, coverage and source iNMF on SCMBench unpaired integration, Yao lit-cells-networks-20261011-scmbench-protocol-unpaired-integration-accuracy Aggregation: Not reported SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration; SCMBench Supplementary Data 2 (integration results) · Supplementary Data 2, sheet 'unpaired_inte_overall', cell B16 (row 'iNMF', column 'Yao')

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SCMBench: benchmarking domain-specific and foundation models for single-cell multi-omics data integration · Original source · Published article, Nature Communications 2026 (PMC13342640.1)
SCMBench Supplementary Data 2 (integration results) · Original source · Supplementary Data 2 (MOESM4) of the published article

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Technical metadata and extraction receipts

Stable ID: lit-cells-networks-20261011-scmbench-config-inmf

areas: single-cell
contexts: research
method types: specialist
reported name: iNMF
foundation model eligible: false
hyperparameters: Defaults for R methods and methods without explicit hyperparameters; tuned otherwise (Methods 'Hyperparameter tuning')
source locator: Supplementary Data 2 method rows; Methods 'Benchmarking setup'
missing metadata: version: reason: unreported
provenance note: iNMF as run in SCMBench: default or tuned hyperparameters per the SCMBench setup.

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