Windowed protection score (WPS), open chromatin regions after PCA dimension reduction, SVM (Hou et al. 2024)

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Windowed protection score (WPS), open chromatin regions after PCA dimension reduction, SVM (Hou et al. 2024)	Protocol: Hou et al. 2024 pan-cancer vs healthy, Cristiano cohort, 10 x 10-fold cross-validation (Table 1 AUC) Dataset: DELFI 2019 internally cross-validated cancer detection cohort	0.965 auroc unitless · higher Uncertainty: 95% CI 0.9596 to 0.9701 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source WPS (open chromatin regions after PCA dimension reduction), pan-cancer vs healthy AUC ctdnafrag-20261009-protocol-hou2024-cristiano-pancan-cv-auc Aggregation: Not reported Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Article Table 1 (advs8741-tbl-0001), row 'WPS', column 'after PCA degradation'

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Release 2026-10-09-ba02f2f4a36e · Record review: source checked

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Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Original source · Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML

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Technical metadata and extraction receipts

Stable ID: ctdnafrag-20261009-config-hou2024-wps-pca

areas: dna-genomes
contexts: clinical_research
method types: supervised_machine_learning
reported name: WPS
foundation model eligible: false
source locator: Article Table 1 row 'WPS', column 'after PCA degradation'; Experimental Section P29-P41
missing metadata: version: reason: unreported; note: Hou et al. re-implementation; no software version or code commit is printed
parameters: Feature setting: open chromatin regions after PCA dimension reduction. Classifier: scikit-learn support vector machine with default parameters.

Related records

configuration of: Windowed protection score (WPS)
system: WPS (open chromatin regions after PCA dimension reduction), pan-cancer vs healthy AUC