AlphaGenome merged splicing score, distilled model, Atlas precomputed (AlphaGenome Atlas v1)
AlphaGenome splice site score plus splice site usage score plus one fifth of the splice junction score, each the maximum over all positions and genes, from the distilled model with 1 Mb context.
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Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Original source · medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Technical metadata and extraction receipts
Stable ID: ag-atlas-20261019-config-alphagenome-merged-splicing
- areas
- dna-genomes
- contexts
- research
- method types
- foundation_model
- reported name
- AlphaGenome merged splicing score (AG Splicing)
- checkpoint
- AlphaGenome distilled model (Avsec et al.)
- parameters
- S_splicing = S_sites + S_usage + S_junctions / 5, each component the maximum over all coordinates and genes. Scorers (Table S1): GeneMaskSplicingScorer requested_output=SPLICE_SITES, width=None; GeneMaskSplicingScorer requested_output=SPLICE_SITE_USAGE, width=None (282 biosamples, 367 tracks); SpliceJunctionScorer (282 biosamples, 367 tracks); stranded scorers merged across strands. Raw scores, no quantile transform. GRCh38, GENCODE v46. Genome tiled into 128 bp windows; each window scored with a 1 Mb input centred on the window, so the variant lies within 64 bp of the centre (not centred on the variant); reference prediction cached per window.
- source locator
- Methods 'Genome-wide inference of AlphaGenome', 'Sliding Window Approach', 'Input Features' item 1 (pages 18 to 22); Table S1 (page 69)
- missing metadata
- version: reason: unreported; note: API or weights release of the distilled model not printed.