Evidence claim

Relevance of tgtval-20261009-protocol-roohani2025-hitratio-round5 to "Which targets should I test to change a defined disease-relevant phenotype?"

Use case: Select therapeutic targets for validation
Assessed by: BioDiscoveryAgent 1-gene perturbation design: hit ratio after 5 rounds of 128 genes
Relevance: Proxy evidence
Endpoint: Hit ratio after 5 rounds of 128 selected genes, over all genes and over non-essential genes only, for 20 selection methods on six CRISPR screens: random selection, a human pathway baseline, seven acquisition functions, DiscoBAX, nine LLM agents and one hybrid

Compares many target-selection methods on the same measured screens for a defined phenotypic readout, which is the use case's question in retrospective form. It is proxy evidence: the screens are replayed offline rather than tested prospectively, the candidate pool is limited to genes each screen assayed, and recovering a screen's hits is not the same as a target being worth pursuing.

120 reviewed evaluations

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Citation locations 1 values source id tgtval-20261009-source-roohani2025 locator Sections 2 and 4.1; Table 1; appendix Table 7 Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Comparison group roohani2025-perturbation-design Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_group` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Comparison title BioDiscoveryAgent benchmark: hit ratio on six CRISPR screens (developer-run) Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_title` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Constraints 3 values Inspect every linked evaluation's source locator and preserved limitations before citing a result. Do not combine this mapping's evaluations with any other protocol's results; screens, hit definitions, candidate pools and metrics differ. Genes absent from a screen's candidate pool are untested, not negative, and no result here says otherwise. Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Endpoint Hit ratio after 5 rounds of 128 selected genes, over all genes and over non-essential genes only, for 20 selection methods on six CRISPR screens: random selection, a human pathway baseline, seven acquisition functions, DiscoBAX, nine LLM agents and one hybrid Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Claimed field links:assessed_by:tgtval-20261009-protocol-roohani2025-hitratio-round5 Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Headline metric recall Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.headline_metric` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Limitations 6 values Offline replay of six existing screens: the candidate pool is the genes each screen assayed, so untested genes are absent rather than negative. Hit ratio measures recovery of that screen's own hits, not whether a target is useful. Hits are defined by a threshold tau on the screen's phenotypic response; the source does not print tau or the hit count per screen. All rows were run by the agent's developers. Two authors (Steinhart, Marson) are authors of the Schmidt et al. 2022 screens, the CAR-T screen is unpublished, and the conflicts statement says patent applications have been filed on the findings. Gupta et al. 2025 report that the same agent performs about the same when its experimental feedback is replaced by randomly permuted outcomes: in their Table 1 the permuted variant scores at least as high on three of five screens with each of three backbones. These numbers should not be read as evidence that the agent learns from each round's results. No linked benchmark here runs a prospective validation batch or measures target usefulness, dependency, tractability, therapeutic window or patient benefit. Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
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tgtval-20261009-result-roohani2025-top-uncertain-schmidt2022-il2-nonessential fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 46e04acdd0741b850e3f0d7aa1a337bfe3d8114456deb24880d4b070bfce12a5 record id tgtval-20261009-source-roohani2025 fields status attributes.artifact_sha256 sha256 2cd7fb822f68bd61204618ad8ffaf1f70dfb094237c5787671c3a3ecfc8afd5b record id use-case-therapeutic-target-validation fields status name description facets attributes.question attributes.decision attributes.inputs attributes.output attributes.exclusions attributes.setting attributes.clinical_scope attributes.intended_users sha256 3b7601f2decfe5a3304ea2c8ccaa89929148f2d443b05bd6c9e92f1844c0a578 Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.pins` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact
Rationale Compares many target-selection methods on the same measured screens for a defined phenotypic readout, which is the use case's question in retrospective form. It is proxy evidence: the screens are replayed offline rather than tested prospectively, the candidate pool is limited to genes each screen assayed, and recovering a screen's hits is not the same as a target being worth pursuing. Negatives are genes the screen assayed whose measured response did not meet its significance criterion. Genes the screen did not assay are excluded from the candidate pool, so the benchmark never treats an untested gene as a negative; it also never tests whether a method would have found a target outside that pool. The agent's developers ran every row, and patent applications have been filed on the findings. Context-only references	BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments Original source ↗ tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7 Version: arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025 Retrieved: 2026-10-09T20:51:27Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.rationale` Source artifact SHA-256: `dd94d80ec75c9bb84ec3989c910a313ef1a7aec57c772d3dd35ecadd250132a7` Hash scope: pdftotext -layout text layer, parsed by extract/extract_target_validation.py Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release history

BioDiscoveryAgent: An AI Agent for Designing Genetic Perturbation Experiments · Original source · arXiv:2405.17631 version 3, updated 2025-03-09; published as a conference paper at ICLR 2025

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Technical metadata and extraction receipts

Stable ID: use-case-mapping-target-validation-20261009-roohani2025-hitratio

field: links:assessed_by:tgtval-20261009-protocol-roohani2025-hitratio-round5
value: tgtval-20261009-protocol-roohani2025-hitratio-round5
relevance: proxy
endpoint: Hit ratio after 5 rounds of 128 selected genes, over all genes and over non-essential genes only, for 20 selection methods on six CRISPR screens: random selection, a human pathway baseline, seven acquisition functions, DiscoBAX, nine LLM agents and one hybrid
rationale: Compares many target-selection methods on the same measured screens for a defined phenotypic readout, which is the use case's question in retrospective form. It is proxy evidence: the screens are replayed offline rather than tested prospectively, the candidate pool is limited to genes each screen assayed, and recovering a screen's hits is not the same as a target being worth pursuing. Negatives are genes the screen assayed whose measured response did not meet its significance criterion. Genes the screen did not assay are excluded from the candidate pool, so the benchmark never treats an untested gene as a negative; it also never tests whether a method would have found a target outside that pool. The agent's developers ran every row, and patent applications have been filed on the findings.
constraints: Inspect every linked evaluation's source locator and preserved limitations before citing a result.; Do not combine this mapping's evaluations with any other protocol's results; screens, hit definitions, candidate pools and metrics differ.; Genes absent from a screen's candidate pool are untested, not negative, and no result here says otherwise.
limitations: Offline replay of six existing screens: the candidate pool is the genes each screen assayed, so untested genes are absent rather than negative.; Hit ratio measures recovery of that screen's own hits, not whether a target is useful.; Hits are defined by a threshold tau on the screen's phenotypic response; the source does not print tau or the hit count per screen.; All rows were run by the agent's developers. Two authors (Steinhart, Marson) are authors of the Schmidt et al. 2022 screens, the CAR-T screen is unpublished, and the conflicts statement says patent applications have been filed on the findings.; Gupta et al. 2025 report that the same agent performs about the same when its experimental feedback is replaced by randomly permuted outcomes: in their Table 1 the permuted variant scores at least as high on three of five screens with each of three backbones. These numbers should not be read as evidence that the agent learns from each round's results.; No linked benchmark here runs a prospective validation batch or measures target usefulness, dependency, tractability, therapeutic window or patient benefit.
citation locators: source id: tgtval-20261009-source-roohani2025; locator: Sections 2 and 4.1; Table 1; appendix Table 7
source locator: tgtval-20261009-source-roohani2025: Sections 2 and 4.1; Table 1; appendix Table 7
revision: 1
reason: Add primary-source target-prioritisation comparisons from the therapeutic target validation use-case pass 2026-10-09.
comparison group: roohani2025-perturbation-design
comparison title: BioDiscoveryAgent benchmark: hit ratio on six CRISPR screens (developer-run)
headline metric: recall
reviewed evaluations: tgtval-20261009-eval-roohani2025-badge-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-badge-cart-proliferation; tgtval-20261009-eval-roohani2025-badge-sanchez2021-tau; tgtval-20261009-eval-roohani2025-badge-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-badge-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-badge-schmidt2022-il2; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-cart-proliferation; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-sanchez2021-tau; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-claude-3-5-sonnet-schmidt2022-il2; tgtval-20261009-eval-roohani2025-claude-3-haiku-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-claude-3-haiku-cart-proliferation; tgtval-20261009-eval-roohani2025-claude-3-haiku-sanchez2021-tau; tgtval-20261009-eval-roohani2025-claude-3-haiku-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-claude-3-haiku-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-claude-3-haiku-schmidt2022-il2; tgtval-20261009-eval-roohani2025-claude-3-opus-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-claude-3-opus-cart-proliferation; tgtval-20261009-eval-roohani2025-claude-3-opus-sanchez2021-tau; tgtval-20261009-eval-roohani2025-claude-3-opus-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-claude-3-opus-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-claude-3-opus-schmidt2022-il2; tgtval-20261009-eval-roohani2025-claude-3-sonnet-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-claude-3-sonnet-cart-proliferation; tgtval-20261009-eval-roohani2025-claude-3-sonnet-sanchez2021-tau; tgtval-20261009-eval-roohani2025-claude-3-sonnet-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-claude-3-sonnet-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-claude-3-sonnet-schmidt2022-il2; tgtval-20261009-eval-roohani2025-claude-v1-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-claude-v1-cart-proliferation; tgtval-20261009-eval-roohani2025-claude-v1-sanchez2021-tau; tgtval-20261009-eval-roohani2025-claude-v1-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-claude-v1-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-claude-v1-schmidt2022-il2; tgtval-20261009-eval-roohani2025-coreset-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-coreset-cart-proliferation; tgtval-20261009-eval-roohani2025-coreset-sanchez2021-tau; tgtval-20261009-eval-roohani2025-coreset-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-coreset-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-coreset-schmidt2022-il2; tgtval-20261009-eval-roohani2025-discobax-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-discobax-cart-proliferation; tgtval-20261009-eval-roohani2025-discobax-sanchez2021-tau; tgtval-20261009-eval-roohani2025-discobax-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-discobax-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-discobax-schmidt2022-il2; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-cart-proliferation; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-sanchez2021-tau; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-gpt-3-5-turbo-schmidt2022-il2; tgtval-20261009-eval-roohani2025-gpt-4o-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-gpt-4o-cart-proliferation; tgtval-20261009-eval-roohani2025-gpt-4o-sanchez2021-tau; tgtval-20261009-eval-roohani2025-gpt-4o-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-gpt-4o-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-gpt-4o-schmidt2022-il2; tgtval-20261009-eval-roohani2025-human-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-human-cart-proliferation; tgtval-20261009-eval-roohani2025-human-sanchez2021-tau; tgtval-20261009-eval-roohani2025-human-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-human-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-human-schmidt2022-il2; tgtval-20261009-eval-roohani2025-k-means-d-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-k-means-d-cart-proliferation; tgtval-20261009-eval-roohani2025-k-means-d-sanchez2021-tau; tgtval-20261009-eval-roohani2025-k-means-d-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-k-means-d-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-k-means-d-schmidt2022-il2; tgtval-20261009-eval-roohani2025-k-means-e-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-k-means-e-cart-proliferation; tgtval-20261009-eval-roohani2025-k-means-e-sanchez2021-tau; tgtval-20261009-eval-roohani2025-k-means-e-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-k-means-e-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-k-means-e-schmidt2022-il2; tgtval-20261009-eval-roohani2025-margin-sample-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-margin-sample-cart-proliferation; tgtval-20261009-eval-roohani2025-margin-sample-sanchez2021-tau; tgtval-20261009-eval-roohani2025-margin-sample-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-margin-sample-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-margin-sample-schmidt2022-il2; tgtval-20261009-eval-roohani2025-o1-mini-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-o1-mini-cart-proliferation; tgtval-20261009-eval-roohani2025-o1-mini-sanchez2021-tau; tgtval-20261009-eval-roohani2025-o1-mini-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-o1-mini-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-o1-mini-schmidt2022-il2; tgtval-20261009-eval-roohani2025-o1-preview-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-o1-preview-cart-proliferation; tgtval-20261009-eval-roohani2025-o1-preview-sanchez2021-tau; tgtval-20261009-eval-roohani2025-o1-preview-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-o1-preview-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-o1-preview-schmidt2022-il2; tgtval-20261009-eval-roohani2025-random-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-random-cart-proliferation; tgtval-20261009-eval-roohani2025-random-sanchez2021-tau; tgtval-20261009-eval-roohani2025-random-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-random-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-random-schmidt2022-il2; tgtval-20261009-eval-roohani2025-soft-uncertain-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-soft-uncertain-cart-proliferation; tgtval-20261009-eval-roohani2025-soft-uncertain-sanchez2021-tau; tgtval-20261009-eval-roohani2025-soft-uncertain-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-soft-uncertain-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-soft-uncertain-schmidt2022-il2; tgtval-20261009-eval-roohani2025-sonnet-coreset-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-sonnet-coreset-cart-proliferation; tgtval-20261009-eval-roohani2025-sonnet-coreset-sanchez2021-tau; tgtval-20261009-eval-roohani2025-sonnet-coreset-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-sonnet-coreset-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-sonnet-coreset-schmidt2022-il2; tgtval-20261009-eval-roohani2025-top-uncertain-carnevale2022-tcell; tgtval-20261009-eval-roohani2025-top-uncertain-cart-proliferation; tgtval-20261009-eval-roohani2025-top-uncertain-sanchez2021-tau; tgtval-20261009-eval-roohani2025-top-uncertain-scharenberg2023-choline; tgtval-20261009-eval-roohani2025-top-uncertain-schmidt2022-ifng; tgtval-20261009-eval-roohani2025-top-uncertain-schmidt2022-il2
review: method: automated-source-review; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent extracted and judged; a separate Claude review agent checked every value and this judgement against the pinned sources (data/omics/use-case-coverage-target-validation-20261009/review.json); reviewed at: 2026-10-09T21:22:54Z; note: Bounded primary-source transcription with independent automated cell check and relevance review. No execution, reproduction, qualified human scientific review or clinical validation.
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