rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare VESPAl. All models

2 findings match, most severe first.

CARP and VESPAl: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks VESPAl above CARP in 15 of 19 comparisons; Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks CARP above VESPAl in 6 of 6 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank CARP above VESPAl in 10 of their 25 comparisons and VESPAl higher in 15. Of those papers, ProteinGym ranks VESPAl higher on its own (15 of 19).

Comparisons in which each paper scores CARP or VESPAl higher2 other papers: CARP higher in 10, VESPAl higher in 15, 0 ties.2 other papers10 CARP higher1015 VESPAl higher15
CARP higherTieVESPAl higher
Compared
CARP, VESPAl

Not reviewed yet.

Tranception and VESPAl: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks Tranception above VESPAl in 17 of 18 comparisons; Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks VESPAl above Tranception in 6 of 7 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank Tranception above VESPAl in 18 of their 26 comparisons and VESPAl higher in 7; 1 is a tie. Of those papers, Livesey and Marsh 2025 ranks VESPAl higher on its own (6 of 7).

Comparisons in which each paper scores Tranception or VESPAl higher2 other papers: Tranception higher in 18, VESPAl higher in 7, 1 tie.2 other papers18 Tranception higher181 tie7 VESPAl higher7
Tranception higherTieVESPAl higher
Compared
Tranception, VESPAl

Not reviewed yet.