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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML · Peer-reviewed

DOI: 10.1093/bib/bbag313

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Records in this release that cite this source. A record can cite several sources.

Results

Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.

ValueMetricModel or configurationDatasetEvaluation
0.7917 fractionAccuracy (HuRI PPI link prediction)GCN with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ComplEx on HuRI (Accuracy)
0.6064 fractionHits at 100 (HuRI PPI link prediction)GCN with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ComplEx on HuRI (Hits@100)
0.9842 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ComplEx on OGBl-ppa (Accuracy)
0.2449 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ComplEx on OGBl-ppa (Hits@100)
0.6715 fractionAccuracy (HuRI PPI link prediction)GCN with majority vote across the representations (PPI embeddings study)HuRI PPI graph (embedding study)GCN / Ensemble on HuRI (Accuracy)
0.5286 fractionHits at 100 (HuRI PPI link prediction)GCN with majority vote across the representations (PPI embeddings study)HuRI PPI graph (embedding study)GCN / Ensemble on HuRI (Hits@100)
0.9416 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with majority vote across the representations (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / Ensemble on OGBl-ppa (Accuracy)
0.2101 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with majority vote across the representations (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / Ensemble on OGBl-ppa (Hits@100)
0.7018 fractionAccuracy (HuRI PPI link prediction)GCN with ESM-2 protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ESM-2 on HuRI (Accuracy)
0.4438 fractionHits at 100 (HuRI PPI link prediction)GCN with ESM-2 protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ESM-2 on HuRI (Hits@100)
0.8729 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ESM-2 protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ESM-2 on OGBl-ppa (Accuracy)
0.1604 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ESM-2 protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ESM-2 on OGBl-ppa (Hits@100)
0.7602 fractionAccuracy (HuRI PPI link prediction)GCN with ESM-IF1 protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ESM-IF1 on HuRI (Accuracy)
0.4968 fractionHits at 100 (HuRI PPI link prediction)GCN with ESM-IF1 protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ESM-IF1 on HuRI (Hits@100)
0.9814 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ESM-IF1 protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ESM-IF1 on OGBl-ppa (Accuracy)
0.1851 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ESM-IF1 protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ESM-IF1 on OGBl-ppa (Hits@100)
0.7044 fractionAccuracy (HuRI PPI link prediction)GCN with PiFold protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / PiFold on HuRI (Accuracy)
0.4573 fractionHits at 100 (HuRI PPI link prediction)GCN with PiFold protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / PiFold on HuRI (Hits@100)
0.8988 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with PiFold protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / PiFold on OGBl-ppa (Accuracy)
0.1893 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with PiFold protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / PiFold on OGBl-ppa (Hits@100)
0.7154 fractionAccuracy (HuRI PPI link prediction)GCN with ProGen2 protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProGen2 on HuRI (Accuracy)
0.4538 fractionHits at 100 (HuRI PPI link prediction)GCN with ProGen2 protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProGen2 on HuRI (Hits@100)
0.9128 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ProGen2 protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProGen2 on OGBl-ppa (Accuracy)
0.2178 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ProGen2 protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProGen2 on OGBl-ppa (Hits@100)
0.6497 fractionAccuracy (HuRI PPI link prediction)GCN with ProstT5 protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProstT5 on HuRI (Accuracy)
0.4470 fractionHits at 100 (HuRI PPI link prediction)GCN with ProstT5 protein embeddings (structure) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProstT5 on HuRI (Hits@100)
0.8081 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ProstT5 protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProstT5 on OGBl-ppa (Accuracy)
0.1616 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ProstT5 protein embeddings (structure) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProstT5 on OGBl-ppa (Hits@100)
0.6750 fractionAccuracy (HuRI PPI link prediction)GCN with ProtTrans protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProtTrans on HuRI (Accuracy)
0.4501 fractionHits at 100 (HuRI PPI link prediction)GCN with ProtTrans protein embeddings (sequence) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / ProtTrans on HuRI (Hits@100)
0.8714 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with ProtTrans protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProtTrans on OGBl-ppa (Accuracy)
0.1677 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with ProtTrans protein embeddings (sequence) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / ProtTrans on OGBl-ppa (Hits@100)
0.6995 fractionAccuracy (HuRI PPI link prediction)GCN with randomly initialised node features (baseline) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / Random on HuRI (Accuracy)
0.4350 fractionHits at 100 (HuRI PPI link prediction)GCN with randomly initialised node features (baseline) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / Random on HuRI (Hits@100)
0.8672 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with randomly initialised node features (baseline) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / Random on OGBl-ppa (Accuracy)
0.0588 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with randomly initialised node features (baseline) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / Random on OGBl-ppa (Hits@100)
0.7989 fractionAccuracy (HuRI PPI link prediction)GCN with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / RDF2Vec on HuRI (Accuracy)
0.6508 fractionHits at 100 (HuRI PPI link prediction)GCN with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / RDF2Vec on HuRI (Hits@100)
0.9816 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / RDF2Vec on OGBl-ppa (Accuracy)
0.2553 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / RDF2Vec on OGBl-ppa (Hits@100)
0.5150 fractionAccuracy (HuRI PPI link prediction)GCN with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / TransE on HuRI (Accuracy)
0.4318 fractionHits at 100 (HuRI PPI link prediction)GCN with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GCN / TransE on HuRI (Hits@100)
0.9010 fractionAccuracy (OGBl-ppa PPI link prediction)GCN with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / TransE on OGBl-ppa (Accuracy)
0.0382 fractionHits at 100 (OGBl-ppa PPI link prediction)GCN with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GCN / TransE on OGBl-ppa (Hits@100)
0.7717 fractionAccuracy (HuRI PPI link prediction)GraphSAGE with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GraphSAGE / ComplEx on HuRI (Accuracy)
0.5622 fractionHits at 100 (HuRI PPI link prediction)GraphSAGE with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)HuRI PPI graph (embedding study)GraphSAGE / ComplEx on HuRI (Hits@100)
0.9741 fractionAccuracy (OGBl-ppa PPI link prediction)GraphSAGE with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GraphSAGE / ComplEx on OGBl-ppa (Accuracy)
0.2758 fractionHits at 100 (OGBl-ppa PPI link prediction)GraphSAGE with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)OGBl-ppa PPI graph (embedding study)GraphSAGE / ComplEx on OGBl-ppa (Hits@100)
0.6221 fractionAccuracy (HuRI PPI link prediction)GraphSAGE with majority vote across the representations (PPI embeddings study)HuRI PPI graph (embedding study)GraphSAGE / Ensemble on HuRI (Accuracy)
0.3121 fractionHits at 100 (HuRI PPI link prediction)GraphSAGE with majority vote across the representations (PPI embeddings study)HuRI PPI graph (embedding study)GraphSAGE / Ensemble on HuRI (Hits@100)

Models, benchmarks and other records

Models (3)

Methods (11)

Configurations (77)

Benchmarks (1)

Protocols (4)

Datasets (2)

Evaluations (308)

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24 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
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attributes.artifact_sha256
360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
Retrieved: 2026-10-11T21:27:23Z

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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13280947/fullTextXML
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
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Doi
10.1093/bib/bbag313
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
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1 values
  • source id
    lit-interactions-20261011-ppiemb-source-bbag313
    artifact sha256
    360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c
    source locator
    Results and discussion, first paragraph; Tables 5 and 6
    message
    The text's summary does not match the tables: it lists ProtT5 among structure embeddings while the tables print ProstT5; it reports a GraphSAGE with DistMult result (+38% Hits@100 on HuRI) although DistMult is not a column; and the stated gains (for example ESM-2 with GraphSAGE +6% Hits@100 on OGBl-ppa) cannot be reproduced from the printed table values (GS random 0.0104, ESM-2 0.2421). Values are kept as printed; comparisons should rely on the tables only after a reviewer has judged this. Random-feature baselines on OGBl-ppa (GCN 0.0588, GS 0.0104 Hits@100) look far below the public OGB leaderboard values the authors say they reproduced (Supplementary Table S2, not retrieved; reviewer did not verify the leaderboard values).
    reviewed at
    2026-10-11T21:40:00Z
    review method
    ai-assisted-source-review
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Licence
CC-BY-NC-4.0
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Limitations
2 values
  • The supplementary material (Tables S1-S7: datasets, original OGBl-ppa leaderboard values, embedding and GNN parameters) was not retrieved.
  • No per-cell uncertainty or run count is printed; the footnote of Tables 5 and 6 gives only the table-wide maximum standard deviation (0.0711 OGBl-ppa, 0.0928 HuRI).
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Publication status
peer_reviewed
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
Retrieved: 2026-10-11T21:27:23Z

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Review: date
2026-10-11
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The role of protein embeddings for protein-protein interaction prediction with graph neural networks

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

Primary source retrieved and hashed for the 2026-10-11 microbial and interactions literature pass.

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Technical metadata and extraction receipts

Stable ID: lit-interactions-20261011-ppiemb-source-bbag313

areas
molecular-interactions; proteins-complexes
contexts
research
url
https://doi.org/10.1093/bib/bbag313
artifact url
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13280947/fullTextXML
version
Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
retrieved at
2026-10-11T21:27:23Z
artifact sha256
360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c
doi
10.1093/bib/bbag313
publication status
peer_reviewed
licence
CC-BY-NC-4.0
media type
application/xml
limitations
The supplementary material (Tables S1-S7: datasets, original OGBl-ppa leaderboard values, embedding and GNN parameters) was not retrieved.; No per-cell uncertainty or run count is printed; the footnote of Tables 5 and 6 gives only the table-wide maximum standard deviation (0.0711 OGBl-ppa, 0.0928 HuRI).
evidence concerns
source id: lit-interactions-20261011-ppiemb-source-bbag313; artifact sha256: 360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c; source locator: Results and discussion, first paragraph; Tables 5 and 6; message: The text's summary does not match the tables: it lists ProtT5 among structure embeddings while the tables print ProstT5; it reports a GraphSAGE with DistMult result (+38% Hits@100 on HuRI) although DistMult is not a column; and the stated gains (for example ESM-2 with GraphSAGE +6% Hits@100 on OGBl-ppa) cannot be reproduced from the printed table values (GS random 0.0104, ESM-2 0.2421). Values are kept as printed; comparisons should rely on the tables only after a reviewer has judged this. Random-feature baselines on OGBl-ppa (GCN 0.0588, GS 0.0104 Hits@100) look far below the public OGB leaderboard values the authors say they reproduced (Supplementary Table S2, not retrieved; reviewer did not verify the leaderboard values).; reviewed at: 2026-10-11T21:40:00Z; review method: ai-assisted-source-review
review
method: source-hash-verification; method note: Full-text XML re-downloaded from the recorded Europe PMC URL and its SHA-256 matched.; reviewer: claude; reviewer note: Claude review agent reviewer-mi-2, independent of the extractor lit-microbial-interactions; no human review claimed; date: 2026-10-11
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