The role of protein embeddings for protein-protein interaction prediction with graph neural networks
Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML · Peer-reviewed
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Results
Values as the source printed them. Compare results only under compatible protocols, datasets and metrics.
Models, benchmarks and other records
Models (3)
Methods (11)
Configurations (77)
- GCN with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- GCN with ESM-2 protein embeddings (sequence) (PPI embeddings study)
- GCN with ESM-IF1 protein embeddings (structure) (PPI embeddings study)
- GCN with majority vote across the representations (PPI embeddings study)
- GCN with PiFold protein embeddings (structure) (PPI embeddings study)
- GCN with ProGen2 protein embeddings (sequence) (PPI embeddings study)
- GCN with ProstT5 protein embeddings (structure) (PPI embeddings study)
- GCN with ProtTrans protein embeddings (sequence) (PPI embeddings study)
- GCN with randomly initialised node features (baseline) (PPI embeddings study)
- GCN with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- GCN with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- GraphSAGE with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- GraphSAGE with ESM-2 protein embeddings (sequence) (PPI embeddings study)
- GraphSAGE with ESM-IF1 protein embeddings (structure) (PPI embeddings study)
- GraphSAGE with majority vote across the representations (PPI embeddings study)
- GraphSAGE with PiFold protein embeddings (structure) (PPI embeddings study)
- GraphSAGE with ProGen2 protein embeddings (sequence) (PPI embeddings study)
- GraphSAGE with ProstT5 protein embeddings (structure) (PPI embeddings study)
- GraphSAGE with ProtTrans protein embeddings (sequence) (PPI embeddings study)
- GraphSAGE with randomly initialised node features (baseline) (PPI embeddings study)
- GraphSAGE with RDF2Vec protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- GraphSAGE with TransE protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- MLP on concatenated protein embeddings (protein-only baseline, no network) with ComplEx protein embeddings (function (knowledge-graph embedding)) (PPI embeddings study)
- MLP on concatenated protein embeddings (protein-only baseline, no network) with ESM-2 protein embeddings (sequence) (PPI embeddings study)
- MLP on concatenated protein embeddings (protein-only baseline, no network) with ESM-IF1 protein embeddings (structure) (PPI embeddings study)
Benchmarks (1)
Protocols (4)
Datasets (2)
Evaluations (308)
- GCN / ComplEx on HuRI (Accuracy)
- GCN / ComplEx on HuRI (Hits@100)
- GCN / ComplEx on OGBl-ppa (Accuracy)
- GCN / ComplEx on OGBl-ppa (Hits@100)
- GCN / Ensemble on HuRI (Accuracy)
- GCN / Ensemble on HuRI (Hits@100)
- GCN / Ensemble on OGBl-ppa (Accuracy)
- GCN / Ensemble on OGBl-ppa (Hits@100)
- GCN / ESM-2 on HuRI (Accuracy)
- GCN / ESM-2 on HuRI (Hits@100)
- GCN / ESM-2 on OGBl-ppa (Accuracy)
- GCN / ESM-2 on OGBl-ppa (Hits@100)
- GCN / ESM-IF1 on HuRI (Accuracy)
- GCN / ESM-IF1 on HuRI (Hits@100)
- GCN / ESM-IF1 on OGBl-ppa (Accuracy)
- GCN / ESM-IF1 on OGBl-ppa (Hits@100)
- GCN / PiFold on HuRI (Accuracy)
- GCN / PiFold on HuRI (Hits@100)
- GCN / PiFold on OGBl-ppa (Accuracy)
- GCN / PiFold on OGBl-ppa (Hits@100)
- GCN / ProGen2 on HuRI (Accuracy)
- GCN / ProGen2 on HuRI (Hits@100)
- GCN / ProGen2 on OGBl-ppa (Accuracy)
- GCN / ProGen2 on OGBl-ppa (Hits@100)
- GCN / ProstT5 on HuRI (Accuracy)
Evidence
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Evidence table
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24 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| attributes.artifact_sha256 360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Artifact url https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13280947/fullTextXML Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Doi 10.1093/bib/bbag313 Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Evidence concerns1 values
| The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Licence CC-BY-NC-4.0 Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Limitations2 values
| The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Media type application/xml Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Publication status peer_reviewed Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Retrieved at 2026-10-11T21:27:23Z Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Review: date 2026-10-11 Source metadata | The role of protein embeddings for protein-protein interaction prediction with graph neural networks No field-specific location recorded Version: Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML | catalogued No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Primary source retrieved and hashed for the 2026-10-11 microbial and interactions literature pass.
Technical metadata and extraction receipts
Stable ID: lit-interactions-20261011-ppiemb-source-bbag313
- areas
- molecular-interactions; proteins-complexes
- contexts
- research
- url
- https://doi.org/10.1093/bib/bbag313
- artifact url
- https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13280947/fullTextXML
- version
- Briefings in Bioinformatics 2026, bbag313; PMC13280947 full-text XML
- retrieved at
- 2026-10-11T21:27:23Z
- artifact sha256
- 360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c
- doi
- 10.1093/bib/bbag313
- publication status
- peer_reviewed
- licence
- CC-BY-NC-4.0
- media type
- application/xml
- limitations
- The supplementary material (Tables S1-S7: datasets, original OGBl-ppa leaderboard values, embedding and GNN parameters) was not retrieved.; No per-cell uncertainty or run count is printed; the footnote of Tables 5 and 6 gives only the table-wide maximum standard deviation (0.0711 OGBl-ppa, 0.0928 HuRI).
- evidence concerns
- source id: lit-interactions-20261011-ppiemb-source-bbag313; artifact sha256: 360d4f17b779e07f170c3f0c3755bfbfddd064831bf5a81d2642a4cfffd4866c; source locator: Results and discussion, first paragraph; Tables 5 and 6; message: The text's summary does not match the tables: it lists ProtT5 among structure embeddings while the tables print ProstT5; it reports a GraphSAGE with DistMult result (+38% Hits@100 on HuRI) although DistMult is not a column; and the stated gains (for example ESM-2 with GraphSAGE +6% Hits@100 on OGBl-ppa) cannot be reproduced from the printed table values (GS random 0.0104, ESM-2 0.2421). Values are kept as printed; comparisons should rely on the tables only after a reviewer has judged this. Random-feature baselines on OGBl-ppa (GCN 0.0588, GS 0.0104 Hits@100) look far below the public OGB leaderboard values the authors say they reproduced (Supplementary Table S2, not retrieved; reviewer did not verify the leaderboard values).; reviewed at: 2026-10-11T21:40:00Z; review method: ai-assisted-source-review
- review
- method: source-hash-verification; method note: Full-text XML re-downloaded from the recorded Europe PMC URL and its SHA-256 matched.; reviewer: claude; reviewer note: Claude review agent reviewer-mi-2, independent of the extractor lit-microbial-interactions; no human review claimed; date: 2026-10-11