Pairwise win rate (average pairwise win rate against all other VEPs, |Spearman| with DMS on shared variants, indirect DMS assays only) of VESPAl (Livesey and Marsh 2025) on Livesey and Marsh 2025 human DMS benchmark set (36 proteins)
56.6% Pairwise win rate (average pairwise win rate against all other VEPs, |Spearman| with DMS on shared variants, indirect DMS assays only)
Methods
- Tested configuration
- VESPAl (Livesey and Marsh 2025)
- Protocol
- Livesey and Marsh 2025 DMS benchmark: pairwise |Spearman| win rate, indirect assays only
- Dataset
- Livesey and Marsh 2025 human DMS benchmark set (36 proteins)
- Procedure
- Livesey and Marsh 2025 DMS benchmark: pairwise |Spearman| win rate, indirect assays only
- Evaluation
- VESPAl: Livesey and Marsh 2025 DMS benchmark: pairwise |Spearman| win rate, indirect assays only
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source: Bootstrap standard deviations appear only as Figure 2 error bars; not printed
- Evidence
- Independent external evaluation · source checkedLivesey and Marsh 2025, Supplementary Material 2 (Tables S1-S8); Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) · Supplementary Material 2, sheet 'Table S5', cell B42 (row 'VESPAl', column 'rank_score_indirect')
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- None; precomputed or locally run predictions
- Scoring implementation
- scipy.stats.spearmanr (scipy 1.5.4, Python 3.6.8); absolute Spearman; the VEP with the higher |rho| on variants scored by the DMS and both VEPs earns the point
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
2 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 56.6130863684317 Individual claims | Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) Supplementary Material 2, sheet 'Table S5', cell B42 (row 'VESPAl', column 'rank_score_indirect') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: PMC12016141 (published 2025-04-22; Genome Biol 26:104) | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-14T15:30:00Z independent paper Audit detailsExtracted by extract/extract_vep.py; independently re-checked by review/check_values.py. Hand-checked sample in the dated review. Value, metric and identity match the source. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
| Reported result 56.6130863684317 Individual claims | Livesey and Marsh 2025, Supplementary Material 2 (Tables S1-S8) Supplementary Material 2, sheet 'Table S5', cell B42 (row 'VESPAl', column 'rank_score_indirect') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2025_3575_MOESM2_ESM.xlsx as published with PMC12016141 | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-14T15:30:00Z independent paper Audit detailsExtracted by extract/extract_vep.py; independently re-checked by review/check_values.py. Hand-checked sample in the dated review. Value, metric and identity match the source. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
2 source records and release history
- Livesey and Marsh 2025, Supplementary Material 2 (Tables S1-S8) · Original source · 13059_2025_3575_MOESM2_ESM.xlsx as published with PMC12016141
- Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) · Original source · PMC12016141 (published 2025-04-22; Genome Biol 26:104)
Technical metadata and extraction receipts
Stable ID: vep-lit-20261014-result-livesey2025-dms-indirect-vespal-rank-score-indirect
- metric
- pairwise-win-rate
- metric direction
- higher
- unit
- percent
- metric qualifier
- average pairwise win rate against all other VEPs, |Spearman| with DMS on shared variants, indirect DMS assays only
- printed value
- 56.6130863684317
- numeric value
- 56.6130863684317
- raw xml value
- 56.613086368431702
- workbook number format
- General
- source locator
- Supplementary Material 2, sheet 'Table S5', cell B42 (row 'VESPAl', column 'rank_score_indirect')
- missing metadata
- uncertainty: reason: unreported; note: Bootstrap standard deviations appear only as Figure 2 error bars; not printed
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T15:30:00Z; artifact sha256: 1b0d792d1a5d3daa95545a7973cabb131c45e42c952e7e5a447a72deef1d1e70; retrieval url: https://static-content.springer.com/esm/art%3A10.1186%2Fs13059-025-03575-w/MediaObjects/13059_2025_3575_MOESM2_ESM.xlsx; method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the Springer workbook and matched the pinned SHA-256. review/check_values.py re-read the sheet XML with its own parser and checked printed value (shortest round-trip decimal of the General-format cell), numeric value, raw cell, cell reference, row label, column header, metric, qualifier, unit, direction, coverage and the linked configuration, protocol and dataset; all 667 workbook results matched.; note: Extracted by extract/extract_vep.py; independently re-checked by review/check_values.py. Hand-checked sample in the dated review. Value, metric and identity match the source.