Count (Successfully subcloned and expressed) of AlphaProteo, pooled over tested design systems on AlphaProteo binder design target TrkA
5 Count (Successfully subcloned and expressed)
Methods
- Tested configuration
- AlphaProteo, pooled over tested design systems
- Protocol
- AlphaProteo expression and HTRF confirmation funnel for yeast-display hits
- Dataset
- AlphaProteo binder design target TrkA
- Procedure
- AlphaProteo expression and HTRF confirmation funnel for yeast-display hits
- Evaluation
- AlphaProteo successfully subcloned and expressed for TrkA (Table S3)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not applicable: An exact count.
- Evidence
- Author-reported evaluation · source checkedDe novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table S3, row 'Successfully subcloned and expressed', column 'TrkA'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- Count of designs surviving the stage
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 5 Individual claims | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table S3, row 'Successfully subcloned and expressed', column 'TrkA' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | source checked ["source-hash-verification","independent-cell-check","ai-assisted-source-review"] · 2026-10-22T15:00:00Z author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsReviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally. Field: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Original source · arXiv version 1, posted 2024-09-12; full-text PDF (49 pages)
Technical metadata and extraction receipts
Stable ID: uc-binder-20261022-result-alphaproteo-s3-subcloned-expressed-trka
- metric
- count
- metric direction
- unknown
- metric qualifier
- Successfully subcloned and expressed
- missing metadata
- denominator: note: Table S3 does not state how many yeast hits were available to select from, so the first stage has no printed denominator.; reason: unreported; uncertainty: note: An exact count.; reason: inapplicable
- numeric value
- 5
- printed value
- 5
- review
- artifact sha256: 953b35644c0fa06ff090d7614c2e19525831f8fde50242e176d54474133c5a42; method: source-hash-verification; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded with curl (HTTP 200, 12,333,400 bytes) and the SHA-256 recomputed and matched. Own text layer made with pdftotext -layout (poppler 26.08.0), reproducing the extraction pass's 2,811 lines. Table 1, Table S2, Table S3 and Sections S1.2.1, S2, S4.1 and S4.2 read cell by cell and compared with every record. Column assignment re-derived arithmetically rather than trusted.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://arxiv.org/pdf/2409.08022v1; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed
- source locator
- Table S3, row 'Successfully subcloned and expressed', column 'TrkA'
- unit
- count
- unit detail
- designs