Dissociation constant (best KD by HTRF among the designs tested for this design system; hotspot conditioning) of AlphaProteo v1 on AlphaProteo binder design target SC2RBD
30 Dissociation constant (best KD by HTRF among the designs tested for this design system; hotspot conditioning)
Methods
- Tested configuration
- AlphaProteo v1
- Protocol
- AlphaProteo best per-target binder affinity by HTRF
- Dataset
- AlphaProteo binder design target SC2RBD
- Procedure
- AlphaProteo best per-target binder affinity by HTRF
- Evaluation
- AlphaProteo v1 on SC2RBD (best KD by HTRF, Table S2)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source: No interval is printed.
- Evidence
- Author-reported evaluation · source checkedDe novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Table S2, 'Binding KD (nM)' block, row 'AlphaProteo v1', column 'SC2RBD'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- Best (lowest) KD among expressed hits, by HTRF
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 30 Individual claims | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Table S2, 'Binding KD (nM)' block, row 'AlphaProteo v1', column 'SC2RBD' Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | source checked ["source-hash-verification","independent-cell-check","ai-assisted-source-review"] · 2026-10-22T15:00:00Z author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsReviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally. Field: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Original source · arXiv version 1, posted 2024-09-12; full-text PDF (49 pages)
Technical metadata and extraction receipts
Stable ID: uc-binder-20261022-result-alphaproteo-s2-kd-v1-sc2rbd-main
- denominator
- 94
- metric
- dissociation-constant
- metric direction
- lower
- metric qualifier
- best KD by HTRF among the designs tested for this design system; hotspot conditioning
- missing metadata
- uncertainty: note: No interval is printed.; reason: unreported
- numeric value
- 30
- printed value
- 30
- review
- artifact sha256: 953b35644c0fa06ff090d7614c2e19525831f8fde50242e176d54474133c5a42; method: source-hash-verification; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded with curl (HTTP 200, 12,333,400 bytes) and the SHA-256 recomputed and matched. Own text layer made with pdftotext -layout (poppler 26.08.0), reproducing the extraction pass's 2,811 lines. Table 1, Table S2, Table S3 and Sections S1.2.1, S2, S4.1 and S4.2 read cell by cell and compared with every record. Column assignment re-derived arithmetically rather than trusted.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://arxiv.org/pdf/2409.08022v1; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed
- source locator
- Table S2, 'Binding KD (nM)' block, row 'AlphaProteo v1', column 'SC2RBD'
- unit
- nanomolar