Result

MCC of ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay) on ProteinGym v1.3 AMFR substitution assay full assay

-0.139 MCC

Methods

Tested configuration: ESM-2 8M masked-marginal scoring (ProteinGym v1.3 AMFR substitution assay)
Protocol: ProteinGym v1.3 AMFR substitution assay
Dataset subset: ProteinGym v1.3 AMFR substitution assay full assay
Related family profiles: ESM-2; ESM-2
Procedure: ProteinGym v1.3 AMFR substitution assay
Evaluation: ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay
Coverage: 2972/2972 scored
Uncertainty: Not reported by the source: Not estimated; one complete selected evaluation.
Evidence: Rewire evaluation · source checkedESM-2 8M masked-marginal scoring: local execution report (20 September 2026); ESM-2 8M masked-marginal scoring: automated execution audit · protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: Full assay; no train/test split
Adaptation: zero-shot masked marginals
Scoring implementation: fcc5ab65e6753cf29aabbdae231cbb5cdf72a3dd40ba8f109802c33223b33536

Generate and evaluate predictions

This committed script regenerates the selected AMFR assay using the recorded checkpoint and masked-marginal scorer. It is not the complete ProteinGym track or a reproduction of a paper score.

ProteinGym v1.3 AMFR substitution assay: reproduction instructions · Reproduce section

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

2 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Reported result -0.139 Individual claims	ESM-2 8M masked-marginal scoring: automated execution audit Original source ↗ protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ca73fa47136d182f2d4ddb083d084712198fc0e2 Retrieved: 2026-09-20T20:54:03Z	source checked ["execution-evidence-review"] · 2026-09-20T20:54:03Z rewire run Audit details Numerical transcription and coverage checked against execution evidence; not human review or reproduction of a published model score. Field: `attributes.printed_value` Source artifact SHA-256: `c0e9ba796883bf9a2918bc5490a62dce8cb06abed32ed9b7026bb0b34bfc6655` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Reported result -0.139 Individual claims	ESM-2 8M masked-marginal scoring: local execution report (20 September 2026) Original source ↗ protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ca73fa47136d182f2d4ddb083d084712198fc0e2 Retrieved: 2026-09-20T20:54:03Z	source checked ["execution-evidence-review"] · 2026-09-20T20:54:03Z rewire run Audit details Numerical transcription and coverage checked against execution evidence; not human review or reproduction of a published model score. Field: `attributes.printed_value` Source artifact SHA-256: `6a14b3866141d5779c76da8071d85c73b7cce0dc4e101c93122706873e847d26` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

3 source records and release history

ESM-2 8M masked-marginal scoring: local execution report (20 September 2026) · Original source · ca73fa47136d182f2d4ddb083d084712198fc0e2
ESM-2 8M masked-marginal scoring: automated execution audit · Original source · ca73fa47136d182f2d4ddb083d084712198fc0e2
ProteinGym v1.3 AMFR substitution assay: reproduction instructions · Original source · ca73fa47136d182f2d4ddb083d084712198fc0e2

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: rewire-local-20260920-result-proteingym-esm2-mcc

areas: proteins-complexes
printed value: -0.139
numeric value: -0.139
metric: matthews-correlation-coefficient
metric key: MCC
metric direction: higher
unit: unitless
eligible count: 2972
scored count: 2972
coverage: scored: 2972; eligible: 2972
source locator: protocol_results.per_assay.AMFR_HUMAN_Tsuboyama_2023_4G3O.metrics.MCC
review: method: execution-evidence-review; reviewer: unidentified-automated-reviewer; reviewed at: 2026-09-20T20:54:03Z; method note: automated; reviewer note: automated report and saved-prediction verification; note: Numerical transcription and coverage checked against execution evidence; not human review or reproduction of a published model score.
missing metadata: uncertainty: reason: unreported; note: Not estimated; one complete selected evaluation.

Related records

evaluation: ESM-2 8M masked-marginal scoring on ProteinGym v1.3 AMFR substitution assay

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