Result

Ligand pass rate of Chai-1 (MSA) on Runs N’ Poses complete-case intersection: 2,573 scored ligands (ESMFold2 Runs N’ Poses reported comparison split)

59% Ligand pass rate

Methods

Tested configuration: Chai-1 (MSA)
Protocol: ESMFold2 Runs N’ Poses reported comparison msa: Runs N’ Poses ligand pass rate (MSA)
Dataset subset: Runs N’ Poses complete-case intersection: 2,573 scored ligands (ESMFold2 Runs N’ Poses reported comparison split)
Related family profiles: Chai-1
Procedure: Runs N’ Poses receptor–ligand co-folding; source benchmark 2,600 systems. Figure 2C reports n=2,573 scored ligands on the intersection where all models produced valid predictions, after excluding undefined SuCOS scores. Multiple ligands in one system are scored independently. Five seeds × five diffusion samples per target; select top candidate by ipTM. Success requires lDDT-PLI >0.8 and BiSyRMSD <2 angstrom. Baselines use 10 recycles and 200 diffusion steps; ESMFold2 uses 10 or 20 loops as labelled and truncated 68-step diffusion. Single-sequence and MSA conditions remain separate.
Evaluation: Chai-1 (MSA) on ESMFold2 Runs N’ Poses reported comparison msa: Runs N’ Poses ligand pass rate (MSA)
Coverage: 2573 ligands scored (Complete-case intersection; source 2600 systems is not a ligand denominator.)
Uncertainty: Not yet extracted
Evidence: Author-reported evaluation · source checkedESMFold2 primary paper v1, Figure 2C Runs N’ Poses · PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), msa block, bar 5 from left (Chai-1 (MSA)), exact printed bar label

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: Not reported
Adaptation: Not reported
Scoring implementation: Ligand pass rate

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Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Reported result 59 Individual claims	ESMFold2 primary paper v1, Figure 2C Runs N’ Poses Original source ↗ PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), msa block, bar 5 from left (Chai-1 (MSA)), exact printed bar label Version: 10.64898/2026.06.03.729735v1; posted 2026-06-04 Retrieved: 2026-09-23T11:22:04.378019+00:00	source checked ["transcription","rendered-source-visual-check"] · 2026-09-23 author reported Audit details Source checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied. Field: `attributes.printed_value` Source artifact SHA-256: `aacaf8d2c9af44cf148138b195175f2751295197bd5e3352ca6f1387059a7127` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `aacaf8d2c9af44cf148138b195175f2751295197bd5e3352ca6f1387059a7127` Extraction artifact

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Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release history

ESMFold2 primary paper v1, Figure 2C Runs N’ Poses · Original source · 10.64898/2026.06.03.729735v1; posted 2026-06-04

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Technical metadata and extraction receipts

Stable ID: esmfold2-2026-runs-n-poses-result-chai-1-msa-msa-ligand-pass-rate

areas: proteins-complexes
tasks: Runs N’ Poses ligand pass rate (MSA)
metric: ligand-pass-rate
metric direction: higher
unit: percent
printed value: 59
numeric value: 59
source locator: PDF page 5, Figure 2C, Runs N’ Poses subpanel (right), msa block, bar 5 from left (Chai-1 (MSA)), exact printed bar label
missing metadata: coverage.eligible: reason: unreported; denominator: reason: unextracted; seeds: reason: unreported; uncertainty: reason: unextracted
review: method: transcription; rendered-source-visual-check; reviewer: codex; date: 2026-09-23; artifact sha256: aacaf8d2c9af44cf148138b195175f2751295197bd5e3352ca6f1387059a7127; retrieval url: https://www.biorxiv.org/content/10.64898/2026.06.03.729735v1.full.pdf; method note: exact printed numerical labels in the complete Figure 2C Runs N’ Poses subpanel; visual original-PDF verification; no graph digitization; reviewer note: role: automated source review; note: Source checked, not reproduced. Metrics differ by task, so no composite score across tasks is computed or implied.
scored count: 2573
coverage: unit: ligands; scored: 2573; note: Complete-case intersection; source 2600 systems is not a ligand denominator.

Related records

evaluation: Chai-1 (MSA) on ESMFold2 Runs N’ Poses reported comparison msa: Runs N’ Poses ligand pass rate (MSA)

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