0.78 auroc
sun2024-methatlas-cfmethyl auroc (lung squamous cell carcinoma vs healthy; random forest on deconvolved cell-type fractions)
- Tested configuration
- MethAtlas (Sun et al. 2024 benchmark)
- Protocol
- Sun et al. 2024 five-cancer detection from deconvolved plasma cfMethyl-Seq (ROC-AUC per cancer type)
- Dataset
- Plasma cfMethyl-Seq, 225 cancer patients and 193 healthy individuals (EGAD00001009003)
- Procedure
- ctdnameth-20261009-protocol-sun2024-cfmethyl-detection-auc
- Evaluation
- MethAtlas deconvolution, disease detection AUC (cfMethyl-Seq cohort)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source
- Evidence
- Independent external evaluation · source checkedSystematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA; Sun et al. 2024, Additional file 1 (Tables S1-S8) · Sun Additional file 1, sheet 'Table S7 ', L8; row 'LUSC'; column 'MethAtlas' under 'AUC values'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- Not reported
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
2 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 0.78 Individual claims | Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA Sun Additional file 1, sheet 'Table S7 ', L8; row 'LUSC'; column 'MethAtlas' under 'AUC values' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit detailsExtracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py, extract/extract_ctdna_methylation.py) with row and column labels asserted. printed_value is the shortest round-trip decimal of the stored cell value, or the displayed text where the workbook applies a fixed-decimals number format (recorded in workbook_number_format); raw_xml_value keeps the stored text. Independent review 2026-10-09: value and identity match the source. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
| Reported result 0.78 Individual claims | Sun et al. 2024, Additional file 1 (Tables S1-S8) Sun Additional file 1, sheet 'Table S7 ', L8; row 'LUSC'; column 'MethAtlas' under 'AUC values' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318 | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit detailsExtracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py, extract/extract_ctdna_methylation.py) with row and column labels asserted. printed_value is the shortest round-trip decimal of the stored cell value, or the displayed text where the workbook applies a fixed-decimals number format (recorded in workbook_number_format); raw_xml_value keeps the stored text. Independent review 2026-10-09: value and identity match the source. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-09-8cc1db47c7f9 · Record review: source checked
2 source records and release history
- Systematic evaluation of methylation-based cell type deconvolution methods for plasma cell-free DNA · Original source · Genome Biology 25:318, published 2024-12-19; PMC11660681.1 full-text XML
- Sun et al. 2024, Additional file 1 (Tables S1-S8) · Original source · Additional file 1 (13059_2024_3456_MOESM1_ESM.xlsx) of Genome Biology 25:318
Technical metadata and extraction receipts
Stable ID: ctdnameth-20261009-result-sun2024-methatlas-cfmethyl-lusc-auroc
- metric
- auroc
- metric qualifier
- lung squamous cell carcinoma vs healthy; random forest on deconvolved cell-type fractions
- metric direction
- higher
- unit
- unitless
- printed value
- 0.78
- numeric value
- 0.78
- source locator
- Sun Additional file 1, sheet 'Table S7 ', L8; row 'LUSC'; column 'MethAtlas' under 'AUC values'
- raw xml value
- 0.78
- review
- method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the workbook and matched its SHA-256. Read the cell with a separate stdlib OOXML reader written for this review (shared strings, raw cell text and number format from styles.xml); the extractor's scripts were not imported or run. Checked raw text, printed value (fixed-decimals display where the cell format applies one, otherwise shortest round-trip decimal), numeric value, metric, qualifier, unit, direction, denominator or scored n, and the linked evaluation's configuration and protocol against the row and column headers.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: 1489ec85628ec60916f2d91faa131fff375436709edb850fee2ef50c860b31b0; retrieval url: https://static-content.springer.com/esm/art%3A10.1186%2Fs13059-024-03456-8/MediaObjects/13059_2024_3456_MOESM1_ESM.xlsx; note: Extracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py, extract/extract_ctdna_methylation.py) with row and column labels asserted. printed_value is the shortest round-trip decimal of the stored cell value, or the displayed text where the workbook applies a fixed-decimals number format (recorded in workbook_number_format); raw_xml_value keeps the stored text. Independent review 2026-10-09: value and identity match the source.
- missing metadata
- uncertainty: reason: unreported
- denominator note
- 41 cases, 193 controls