0.958 sensitivity-at-85-percent-specificity
hou2024-s2-end-motif-cristiano sensitivity-at-85-percent-specificity (ovarian cancer vs healthy; mean of 10 x 10-fold cross-validation)
- Tested configuration
- Fragment 5' end motif (4-mer), open chromatin regions, SVM (Hou et al. 2024)
- Protocol
- Hou et al. 2024 Cristiano cohort cross-validation, pan-cancer and seven cancer types (Table S2)
- Dataset
- DELFI 2019 internally cross-validated cancer detection cohort
- Procedure
- ctdnafrag-20261009-protocol-hou2024-cristiano-cv-sensitivity
- Evaluation
- EDM (open chromatin), Cristiano cohort cross-validation
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- 95% CI 0.9293 to 0.9873
- Evidence
- Independent external evaluation · source checkedSystematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S2, E72; group 'OV'; row 'EDM'; column 'Sensitivity @85% specificity'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- 10 repeats of 10-fold cross-validation
- Adaptation
- SVM trained per fold and per comparison
- Scoring implementation
- Not reported
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
2 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 0.9583 Individual claims | Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Supporting Information sheet S2, E72; group 'OV'; row 'EDM'; column 'Sensitivity @85% specificity' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit detailsExtracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py) with sheet title, header and row labels asserted. Text cells hold the value and its 95% CI; printed_value is the leading number and raw_xml_value the full stored text. Independent review 2026-10-09: value and identity match the source. Table S9 covers only the pan-cancer models, so these per-cancer sensitivities have no second table to check against; the pan-cancer and liver blocks of the same table are disputed. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
| Reported result 0.9583 Individual claims | Hou et al. 2024, Supporting Information workbook (Tables S1-S15) Supporting Information sheet S2, E72; group 'OV'; row 'EDM'; column 'Sensitivity @85% specificity' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1 | source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit detailsExtracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py) with sheet title, header and row labels asserted. Text cells hold the value and its 95% CI; printed_value is the leading number and raw_xml_value the full stored text. Independent review 2026-10-09: value and identity match the source. Table S9 covers only the pan-cancer models, so these per-cancer sensitivities have no second table to check against; the pan-cancer and liver blocks of the same table are disputed. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-09-ba02f2f4a36e · Record review: source checked
2 source records and release history
- Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Original source · Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
- Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Original source · ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Technical metadata and extraction receipts
Stable ID: ctdnafrag-20261009-result-hou2024-s2-end-motif-ov-sens85
- metric
- sensitivity-at-85-percent-specificity
- metric qualifier
- ovarian cancer vs healthy; mean of 10 x 10-fold cross-validation
- metric direction
- higher
- unit
- fraction
- printed value
- 0.9583
- numeric value
- 0.9583
- source locator
- Supporting Information sheet S2, E72; group 'OV'; row 'EDM'; column 'Sensitivity @85% specificity'
- review
- method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the workbook and matched its SHA-256. Read the cell with a separate stdlib OOXML reader written for this review (shared strings, raw cell text, and the number format from styles.xml, General for every extracted cell); the extractor's scripts were not imported or run. Built each cell's identity from the sheet title, header row and row labels, then checked raw text, printed value (shortest round-trip decimal, or the leading number of a text cell), numeric value, interval, metric, qualifier, unit, direction, denominator, and the linked evaluation's configuration, protocol and dataset.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0; retrieval url: https://pmc-oa-opendata.s3.amazonaws.com/PMC11321639.1/ADVS-11-2308243-s001.xlsx; note: Extracted by deterministic parse of the pinned XLSX cell XML (extract/rawxlsx.py) with sheet title, header and row labels asserted. Text cells hold the value and its 95% CI; printed_value is the leading number and raw_xml_value the full stored text. Independent review 2026-10-09: value and identity match the source. Table S9 covers only the pan-cancer models, so these per-cancer sensitivities have no second table to check against; the pan-cancer and liver blocks of the same table are disputed.
- uncertainty
- type: confidence_interval; lower: 0.9293; upper: 0.9873; level: 0.95; printed: 95 CI: 0.9293 - 0.9873
- raw xml value
- 0.9583 (95 CI: 0.9293 - 0.9873)
- denominator note
- 28 cancer patients and 215 healthy individuals (article P24)