Protocol

ClusPro BM5 Enzyme top10

At least one acceptable-or-better model (DockQ≥0.23) among the centers of the 10 most populated clusters. Uses existing component structures; no de novo cofolding claim.

1 evaluation · 11 results

Overview

At least one acceptable-or-better model (DockQ≥0.23) among the centers of the 10 most populated clusters. Uses existing component structures; no de novo cofolding claim.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

1 recorded evaluation, 11 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

1 evaluation · 11 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	51 targets_with_acceptable_or_better_model targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; Good models Number
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	3 acceptable_or_better_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; difficult column; acceptable_or_better_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	0 high_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; difficult column; high_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	1 medium_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; difficult column; medium_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	44 acceptable_or_better_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; easy column; acceptable_or_better_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	2 high_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; easy column; high_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	18 medium_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; easy column; medium_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	4 acceptable_or_better_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; intermediate column; acceptable_or_better_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	0 high_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; intermediate column; high_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	2 medium_accuracy_targets targets · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; intermediate column; medium_accuracy_targets
Configuration: ClusPro BM5 Table1 enzyme-balanced	Protocol: ClusPro BM5 Enzyme top10 Dataset subset: BM5 Enzyme Table1 cohort	58% success_at_10 percent · higher Uncertainty: type: unreported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source ClusPro Enzyme top10 Not reported Aggregation: Not reported Performance and its limits in rigid body protein-protein docking · Table1 Enzyme, first (top10) row; Good models %

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

Methods and evaluation design

Procedure, tasks and evaluated configurations

Evaluation design

Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.

Benchmarks

ClusPro Protein Docking Benchmark 5.0 study

These source-backed links do not make different protocols or scores interchangeable.

Recorded evaluations

Each evaluation records what was tested and under which conditions.

ClusPro Enzyme top10

Baseline coverage

Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.

Author-reported evaluations: 1

Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.

Null control

Proposed control: requires review

Protocol-specific valid geometric or structural control

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Conventional reference

Proposed control: requires review

Upstream conventional structural reference with matched templates and cutoffs

Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.

This is a suggested selection rule, not a validated method or a measured score.

Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums

Coverage is derived from release 2026-09-30-e37e3ab1284d. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.

Run instructions

No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

Strengths, limitations and unresolved questions

Applicable tests and references

Applicability is distinct from a completed evaluation.

ClusPro conventional docking baseline: Enzyme · source_supported

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-30-e37e3ab1284d
Property and statement	Original source and location	Review and provenance
Relationship: part of ucc-docking-cluspro-bm5-2020-benchmark Individual claims	Performance and its limits in rigid body protein-protein docking Original source ↗ Table1 Version: Structure 28(9):1071–1081.e3; 2020; PMC author manuscript NIHMS1608597 Retrieved: 2026-09-30T21:50:23.483497+00:00	source checked automated source review · 2026-09-30T21:50:23.483497+00:00 Audit details Source transcription only; not execution, human scientific review or independent reproduction. Field: `links:part_of:ucc-docking-cluspro-bm5-2020-benchmark` Claim: ucc-docking-cluspro-bm5-2020-claim-protocol-enzyme-top10 Source artifact SHA-256: `1c02bd7c53eb0e5d5c243b5e6da23168eb20bcc32ab970719666a5838fd58443` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Sources and history

View linked audit checks and correction history

Release 2026-09-30-e37e3ab1284d · Record review: source checked

1 source records and release history

Performance and its limits in rigid body protein-protein docking · Original source · Structure 28(9):1071–1081.e3; 2020; PMC author manuscript NIHMS1608597

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Technical metadata and extraction receipts

Stable ID: ucc-docking-cluspro-bm5-2020-protocol-enzyme-top10

areas: proteins-complexes
version: 2020 Table1
source locator: Table1 Enzyme row 1; footnotes b–d; Results first paragraph
review: method: automated_source_review; reviewed at: 2026-09-30T21:50:23.483497+00:00; date: 2026-09-30; reviewer: Codex primary-source table extraction; note: Source transcription only; not execution, human scientific review or independent reproduction.
capacity: 10
success threshold: metric: DockQ; value: 0.23
limitations: Some targets generate fewer than30 clusters.; Historical structural-input docking benchmark; separate from FoldBench/AlphaFold protocols.; BM5 contains targets used in prior parameter studies; not an asserted blind prospective holdout.

Related records

part of: ClusPro Protein Docking Benchmark 5.0 study
applicable to: ClusPro conventional docking baseline: Enzyme
subject: Enzyme top10 study membership
protocol: ClusPro Enzyme top10

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