rewirebio.iobenchmarks
Protocol

Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference

Rank TF-target candidate edges by absolute weight; early precision ratio scores the top K edges (K = number of reference edges) and AUPRC ratio the full ranked list, each over a random predictor, against the OmniPath signalling and pathway interactions reference.

147 evaluations · 294 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

147 recorded evaluations, 294 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.

View coverage and remaining gaps across all benchmarks

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

147 evaluations · 294 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: DeepSEM (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.23 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DeepSEM GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'ML', column 'DeepSEM'
Configuration: DeepSEM (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
2.26 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DeepSEM GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'ML', column 'DeepSEM'
Configuration: Geneformer attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.07 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'attn', column 'Geneformer'
Configuration: Geneformer attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.57 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'attn', column 'Geneformer'
Configuration: Geneformer coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.91 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'coshid', column 'Geneformer'
Configuration: Geneformer coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.442 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'coshid', column 'Geneformer'
Configuration: Geneformer costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.955 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'costok', column 'Geneformer'
Configuration: Geneformer costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.736 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Geneformer costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'costok', column 'Geneformer'
Configuration: GENIE3 (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.979 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENIE3 GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'ML', column 'GENIE3'
Configuration: GENIE3 (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.42 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GENIE3 GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'ML', column 'GENIE3'
Configuration: GRNBoost (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.89 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GRNboost GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'ML', column 'GRNboost'
Configuration: GRNBoost (Ye et al. 2026 baseline)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
2.45 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

GRNboost GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'ML', column 'GRNboost'
Configuration: LangCell attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.886 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'attn', column 'Langcell'
Configuration: LangCell attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.03 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'attn', column 'Langcell'
Configuration: LangCell coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.09 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'coshid', column 'Langcell'
Configuration: LangCell coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.52 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'coshid', column 'Langcell'
Configuration: LangCell costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.959 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'costok', column 'Langcell'
Configuration: LangCell costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.761 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

LangCell costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'costok', column 'Langcell'
Configuration: scCello attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.13 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'attn', column 'scCello'
Configuration: scCello attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.45 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'attn', column 'scCello'
Configuration: scCello coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.21 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'coshid', column 'scello'
Configuration: scCello coshid GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.89 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello coshid GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'coshid', column 'scCello'
Configuration: scCello costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.06 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'costok', column 'scello'
Configuration: scCello costok GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
1.47 Early precision ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scCello costok GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 4, block 'OmniPath', row 'hESC', column group 'costok', column 'scCello'
Configuration: scFoundation attn GRN (Ye et al. 2026)Protocol: Ye et al. 2026 GRN reconstruction, TFs+500, OmniPath reference
Dataset subset: BEELINE hESC, TFs+500 (Ye et al. 2026)
0.976 AUPRC ratio (TFs+500 gene set; OmniPath reference)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

scFoundation attn GRN on hESC, TFs+500, OmniPath

lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

Aggregation: Not reported

Benchmarking Static Gene Regulatory Network Reconstruction and Dynamic Transition Probing in Single-Cell Foundation Models · Table 6, block 'OmniPath', row 'hESC', column group 'attn', column 'scFoundation'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Methods and evaluation design

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Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.

0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.

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External evaluations
147

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Technical metadata and extraction receipts

Stable ID: lit-cells-networks-20261011-ye2026grn-protocol-tf-plus-500-omnipath

areas
biological-networks; single-cell
contexts
research
protocol
TFs+500 gene set; candidate space restricted to reference TFs as sources and reference-set genes as targets; OmniPath reference network; early precision and precision-recall over ranked edges (Appendix B.2).
version
bioRxiv v1
metric
early-precision-ratio
metric direction
higher
unit
unitless
limitations
One run per dataset; dataset-level spread only.; Ratios over a random predictor depend on reference network density, so values are not comparable across references or gene sets.
source locator
Tables 4-7; Section 2.2; Appendix B.2
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