Perturbation-first AUROC, RPE1 CRISPRi restricted to the top 2,000 HVGs (Kendiukhov 2026)
As the RPE1 CRISPRi protocol, with the evaluation universe restricted to the top 2,000 highly variable genes to match the K562 protocol.
Overview
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1 recorded evaluation, 1 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
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All evaluations
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Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
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Baseline coverage
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- External evaluations
- 1
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Null control
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No-change prediction under matched control conditions
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Conventional reference
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Training-only mean-effect or linear prediction
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Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
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Run instructions
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Evidence
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Evidence table
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) · Original source · Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14)
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-kendiukhov2026-protocol-pf-rpe1-crispri-hvg2000
- areas
- single-cell; biological-networks
- contexts
- research
- protocol
- As the RPE1 CRISPRi perturbation-first protocol, but restricted to the top 2,000 HVGs (matching the K562 protocol) instead of 3,309 genes with perturbation genes forced in.
- version
- BMC Genomics 27:634
- metric implementation
- Per-perturbation AUROC for classifying differentially expressed targets; summary across perturbations not stated
- source locator
- Page 10, 'Context-dependent attention-correlation relationship'
- limitations
- Single run; no repeat across seeds reported.; Only the attention advantage over correlation is printed; the absolute AUROCs are not.