AFFIPred
Ensemble machine-learning classifier of missense variant pathogenicity that combines sequence features with structural features computed on AlphaFold2 models, including solvent accessibility on full-length structures. The authors report predictions for over 210 million human proteome variants.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
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Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Pir and Timucin 2025, Protein Science 34:e70030 (PMC article page) · Original source · PMC11751861 (Protein Sci 2025;34:e70030, published version of the 2024 bioRxiv preprint)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-affipred
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- AFFIPred
- entity level
- method
- access
- Predictions at https://affipred.timucinlab.com/; code at https://github.com/timucinlab/AFFIPred (paper text)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: b3ea9f1fbbfd16760ebff96c8829f401c5836ed861a0db53de3ef33aff44fca8; retrieval url: https://pmc.ncbi.nlm.nih.gov/articles/PMC11751861/; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.