Method

Oncogenicity Variant Interpreter (OncoVI)

Automated criteria-based somatic oncogenicity interpretation method.

Overview

Automated criteria-based somatic oncogenicity interpretation method.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

4 evaluations · 25 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	83% accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, accuracy; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	81.1% missense_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, missense_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	76.1% oncogene_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, oncogene_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	84% oncogenic_sensitivity percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, oncogenic_sensitivity; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	87.5% truncating_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, truncating_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: ClinVar April 2025 oncogenicity assertions Dataset: ClinVar April 2025 oncogenicity assertions	85.7% tsg_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: ClinVar April 2025 oncogenicity assertions Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, ClinVar April 2025 oncogenicity assertions, tsg_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: MTB selected expert reassessment Dataset: MTB selected expert reassessment	80% expert_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: MTB selected expert reassessment Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, MTB selected expert reassessment, expert_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: MTB selected expert reassessment Dataset: MTB selected expert reassessment	22% prior_mtb_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: MTB selected expert reassessment Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, MTB selected expert reassessment, prior_mtb_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: MTB selected expert reassessment Dataset: MTB selected expert reassessment	0.7 score_correlation correlation coefficient · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: MTB selected expert reassessment Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Figure 4C, concordant variants only
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	43% benign_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, benign_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	78% concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	78.2% missense_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, missense_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	82.5% oncogene_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, oncogene_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	79% oncogenic_vs_pathogenic_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, oncogenic_vs_pathogenic_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	49.4% truncating_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, truncating_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	76% tsg_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, tsg_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Erlangen MTB variants Dataset: Erlangen MTB variants	97% vus_concordance percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Erlangen MTB variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Erlangen MTB variants, vus_concordance; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	81% accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, accuracy; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	83% benign_sensitivity percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, benign_sensitivity; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	83.1% missense_accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, missense_accuracy; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	82% oncogene_accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, oncogene_accuracy; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	88% oncogenic_sensitivity percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, oncogenic_sensitivity; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	0.87 score_correlation correlation coefficient · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Figure 2B, concordant variants only
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	77.7% truncating_accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, truncating_accuracy; subgroup values correspond to Supplemental Table S6
Configuration: OncoVI 2026 publication configuration	Protocol: OncoVI three-class assessment: Guideline SOP variants Dataset: Guideline SOP variants	87.1% tsg_accuracy percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source OncoVI: Guideline SOP variants Not reported Aggregation: Not reported Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Results, Guideline SOP variants, tsg_accuracy; subgroup values correspond to Supplemental Table S6

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

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Oncogenicity Variant Interpreter (OncoVI) Supports Harmonized Somatic Variant Interpretation in Precision Oncology · Original source · 2026 final full text in Europe PMC XML

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Technical metadata and extraction receipts

Stable ID: uc-clinical-20260930-method-oncovi

areas: dna-genomes
contexts: clinical_research
source locator: Methods and OncoVI implementation
review: method: automated_source_review; reviewer: Codex clinical coverage worker; date: 2026-09-30; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20260930-source-oncovi

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