BLOSUM62
Unsupervised baseline that scores a protein variant by its BLOSUM62 substitution score relative to the wild type.
4 evaluations · 4 results1 configuration with further results
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
4 evaluations · 4 results. Different protocols are not a single leaderboard.
Sorted by Spearman (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.
All 4 result rows with coverage, uncertainty and sources
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Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Method: BLOSUM62 | Task: FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Dataset subset: FLIP GB1, 1-vs-rest split (FLIP split) | 0.15 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBLOSUM62 on FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(BLOSUM62), column(1-vs-rest) |
| Method: BLOSUM62 | Task: FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Dataset subset: FLIP GB1, 2-vs-rest split (FLIP split) | 0.14 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBLOSUM62 on FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(BLOSUM62), column(2-vs-rest) |
| Method: BLOSUM62 | Task: FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Dataset subset: FLIP GB1, 3-vs-rest split (FLIP split) | 0.01 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBLOSUM62 on FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(BLOSUM62), column(3-vs-rest) |
| Method: BLOSUM62 | Task: FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Dataset subset: FLIP GB1, low-vs-high split (FLIP split) | -0.13 Spearman unitless · higher Uncertainty: Not yet extracted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBLOSUM62 on FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split Trained on the split's training set with ten percent held out for validation, scored on its test set. Aggregation: Not reported flip primary benchmark evidence · Table 4, row(BLOSUM62), column(low-vs-high) |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
Further results on linked records
One linked record has results that are not included above, because no reviewed claim yet ties the link to this method. Each record keeps its own settings and evaluations, and its scores are on its own page.
- BLOSUM62 (Livesey and Marsh 2025) Configuration · configuration · 6 evaluations · 7 results
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Strengths, limitations and unresolved questions
Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- flip primary benchmark evidence · Original source · 2021 manuscript
Technical metadata and extraction receipts
Stable ID: flip-method-blosum62
- areas
- proteins-complexes
- source locator
- Table 4, row(BLOSUM62)
- missing metadata
- checkpoint revision: reason: unreported; parameters: reason: unextracted
Related records
- system: BLOSUM62 on FLIP GB1-1-VS-REST: GB1 fitness prediction, 1-vs-rest split
- system: BLOSUM62 on FLIP GB1-2-VS-REST: GB1 fitness prediction, 2-vs-rest split
- system: BLOSUM62 on FLIP GB1-3-VS-REST: GB1 fitness prediction, 3-vs-rest split
- system: BLOSUM62 on FLIP GB1-LOW-VS-HIGH: GB1 fitness prediction, low-vs-high split
- configuration of: BLOSUM62 (Livesey and Marsh 2025)