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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BindCraft default settings | Protocol: BindCraft per-target binding screen, hit where a binding signal was observed Dataset: BindCraft binder design target PD-1 | a binding signal for 13 binders Count (designs with an observed binding signal (BLI, bivalent Fc-fusion format), out of designs tested) count · higher Uncertainty: Not applicable: An exact count. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft binding screen against PD-1 uc-binder-20261022-protocol-bindcraft-binding-screen Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' |
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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
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BindCraft per-target binding screen, hit where a binding signal was observed
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22 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Candidate selection About 10 designs from the top 20 ranked by the pipeline's own i_pTM score. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: adaptation Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Count per target Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget 53 designs expressed, purified and assayed Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version PD-1, Supplementary Table 1 input Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs Target structure and hotspot residues from Supplementary Table 1 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Count of tested designs with an observed binding signal (BLI, bivalent Fc-fusion format) Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population 53 BindCraft designs tested against PD-1 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id uc-binder-20261022-protocol-bindcraft-binding-screen Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'We purified and screened 53 designs for binding using biolayer interferometry (BLI) in a bivalent Fc-fusion format. We observed a binding signal for 13 binders' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-eval-bindcraft-screen-pd1