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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BindCraft default settings | Protocol: BindCraft best per-target binder affinity Dataset: BindCraft binder design target PD-1 | lower than 1 nM Dissociation constant (binder2; apparent KD (Kd*) by BLI in a bivalent Fc-fusion format; the exact value could not be determined) nanomolar · lower Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft best binder affinity against PD-1 uc-binder-20261022-protocol-bindcraft-best-affinity Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' |
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BindCraft best per-target binder affinity
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Best KD among the binders identified for the target Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version PD-1, Supplementary Table 1 input Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs Target structure and hotspot residues from Supplementary Table 1 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation binder2; apparent KD (Kd*) by BLI in a bivalent Fc-fusion format; the exact value could not be determined Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id uc-binder-20261022-protocol-bindcraft-best-affinity Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Not reported Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | missing or unspecified No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Conventional baseline None run on this target. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Binders targeting cell-surface receptors', paragraph 1: 'with the best binder showing an apparent dissociation constant (Kd*) lower than 1 nM (Fig. 2a,b), although the exact Kd could not be determined due to the extremely slow dissociation rate and avidity effect from the Fc-fusion construct' Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded author reported Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-eval-bindcraft-affinity-pd1