rewirebio.iobenchmarks
Evaluation

Pangolin on all labelled MFASS SNVs

Published comparison; transcribed, not reproduced.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-10-6e93f504adfc · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 3 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Pangolin (Znabu et al. 2026)Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026)
Dataset: MFASS v2 eligible assay cohort
0.421 average-precision
unitless · higher

Uncertainty: 95% CI 0.386 to 0.454

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Pangolin on all labelled MFASS SNVs

splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort

Aggregation: Not reported

A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'Pangolin', columns 'AP' and 'AP 95% CI'
Configuration: Pangolin (Znabu et al. 2026)Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026)
Dataset: MFASS v2 eligible assay cohort
0.888 auroc
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Pangolin on all labelled MFASS SNVs

splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort

Aggregation: Not reported

A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'Pangolin', column 'AUROC'
Configuration: Pangolin (Znabu et al. 2026)Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026)
Dataset: MFASS v2 eligible assay cohort
27,733 count
count · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Pangolin on all labelled MFASS SNVs

splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort

Aggregation: Not reported

A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'Pangolin', column 'n'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

Evaluation procedure

splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort

Configuration
Pangolin (Znabu et al. 2026)
Protocol
MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026)
Dataset
MFASS v2 eligible assay cohort
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
dataset version
MFASS public processed table (hg38), v2 inclusion labels
split
None (whole labelled cohort)
population
27,733 scored of 27,733 labelled MFASS SNVs
inputs
hg38 genomic context, reference versus alternate
adaptation
None; published weights
metric implementation
AUROC and average precision
aggregation
Pooled over variants
budget
Not reported
protocol id
splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
None (whole labelled cohort)
Adaptation
None; published weights
Scoring implementation
AUROC and average precision

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
None; published weights
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.aggregation
Pooled over variants
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.dataset_version
MFASS public processed table (hg38), v2 inclusion labels
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.inputs
hg38 genomic context, reference versus alternate
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.metric_implementation
AUROC and average precision
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.population
27,733 scored of 27,733 labelled MFASS SNVs
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.protocol_id
splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.comparison.split
None (whole labelled cohort)
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

attributes.origin
independent_paper
Context-only references
A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot

Original source ↗

Section 4 'Results' table (page 3), row 'Pangolin'

Version: bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF
Retrieved: 2026-10-09T20:52:21Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: 52a2d1ccfd99ef62f847b323030acdb7d881ae75b6c9dda8805884a2e7727552

Hash scope: SHA-256 of the PDF as served. The PDF ModDate is 2026-10-09 21:52:24 BST; a re-download at review on 2026-10-09 returned identical bytes. bioRxiv can re-stamp the PDF on later downloads, so if the hash stops matching, compare the text layer.

Inspected artifact

Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

1 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: splicing-follow-up-20261009-eval-znabu2026-pangolin

areas
dna-genomes
contexts
research
origin
independent_paper
protocol
splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort
version
Primary source as retrieved 2026-10-09
comparison
dataset version: MFASS public processed table (hg38), v2 inclusion labels; split: None (whole labelled cohort); population: 27,733 scored of 27,733 labelled MFASS SNVs; inputs: hg38 genomic context, reference versus alternate; adaptation: None; published weights; metric implementation: AUROC and average precision; aggregation: Pooled over variants; budget: Not reported; protocol id: splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort
source locator
Section 4 'Results' table (page 3), row 'Pangolin'
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