rewirebio.iobenchmarks
Evaluation

DeepSom-ESAD on seqc2-snv tumour-only (Krishnamachari et al. 2026)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: DeepSom-ESAD, tumour-only Illumina WGS (Krishnamachari et al. 2026)Protocol: SEQC2 HCC1395 tumour-only, SNVs, AUPRC (Krishnamachari et al. 2026 Supplementary Table 1)
Dataset: SEQC2 HCC1395 tumour Illumina HiSeq WGS (WGS_IL_T_1), high-confidence regions
0.577 AUPRC (SNV only, tumour-only)
fraction · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

DeepSom-ESAD on seqc2-snv tumour-only (Krishnamachari et al. 2026)

somatic-varnet-t-20261011-protocol-seqc2-snv

Aggregation: Not reported

Improved tumor-only variant calling and mutation burden estimation with VarNet-T; VarNet-T Supplementary Information; VarNet-T Source Data workbook · Supplementary Table 1, row 'DeepSom-ESAD', column 'SEQC2 SNV'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

SEQC2 HCC1395 tumour-only, SNVs, AUPRC (Krishnamachari et al. 2026 Supplementary Table 1)

Configuration
DeepSom-ESAD, tumour-only Illumina WGS (Krishnamachari et al. 2026)
Protocol
SEQC2 HCC1395 tumour-only, SNVs, AUPRC (Krishnamachari et al. 2026 Supplementary Table 1)
Dataset
SEQC2 HCC1395 tumour Illumina HiSeq WGS (WGS_IL_T_1), high-confidence regions
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
somatic-varnet-t-20261011-protocol-seqc2-snv
dataset version
Not reported
split
Not in VarNet-T training
population
Not reported
inputs
Tumour Illumina WGS only
adaptation
Not reported
metric implementation
AUPRC over the caller's own score
aggregation
Per sample
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not in VarNet-T training
Adaptation
Not reported
Scoring implementation
AUPRC over the caller's own score

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

54 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Not reported
Context-only references
Improved tumor-only variant calling and mutation burden estimation with VarNet-T

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature Communications, published 2026-04-09; PMC13243554 full-text XML
Retrieved: 2026-10-11T21:37:39Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b42db521781cd548b5ce0cf99233f8e790781fb5e8953fe733202009dd8367bb

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: adaptation
Not reported
Context-only references
VarNet-T Source Data workbook

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Source Data file (41467_2026_71705_MOESM6_ESM.xlsx)
Retrieved: 2026-10-11T21:51:40Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 4a2deae733ff93a9ae0001053816d82fb60787b01646183c8d37fbc5a764cd17

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: adaptation
Not reported
Context-only references
VarNet-T Supplementary Information

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary Information PDF (41467_2026_71705_MOESM1_ESM.pdf), 28 pages
Retrieved: 2026-10-11T21:51:40Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: c808b4361e17a64911a59ded81d9db04c7a3dd5ba95fb3e1e060a293182f2842

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Per sample
Context-only references
Improved tumor-only variant calling and mutation burden estimation with VarNet-T

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature Communications, published 2026-04-09; PMC13243554 full-text XML
Retrieved: 2026-10-11T21:37:39Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b42db521781cd548b5ce0cf99233f8e790781fb5e8953fe733202009dd8367bb

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Per sample
Context-only references
VarNet-T Source Data workbook

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Source Data file (41467_2026_71705_MOESM6_ESM.xlsx)
Retrieved: 2026-10-11T21:51:40Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 4a2deae733ff93a9ae0001053816d82fb60787b01646183c8d37fbc5a764cd17

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
Per sample
Context-only references
VarNet-T Supplementary Information

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary Information PDF (41467_2026_71705_MOESM1_ESM.pdf), 28 pages
Retrieved: 2026-10-11T21:51:40Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: c808b4361e17a64911a59ded81d9db04c7a3dd5ba95fb3e1e060a293182f2842

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
Improved tumor-only variant calling and mutation burden estimation with VarNet-T

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature Communications, published 2026-04-09; PMC13243554 full-text XML
Retrieved: 2026-10-11T21:37:39Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b42db521781cd548b5ce0cf99233f8e790781fb5e8953fe733202009dd8367bb

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
VarNet-T Source Data workbook

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Source Data file (41467_2026_71705_MOESM6_ESM.xlsx)
Retrieved: 2026-10-11T21:51:40Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 4a2deae733ff93a9ae0001053816d82fb60787b01646183c8d37fbc5a764cd17

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Not reported
Context-only references
VarNet-T Supplementary Information

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Supplementary Information PDF (41467_2026_71705_MOESM1_ESM.pdf), 28 pages
Retrieved: 2026-10-11T21:51:40Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: c808b4361e17a64911a59ded81d9db04c7a3dd5ba95fb3e1e060a293182f2842

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Improved tumor-only variant calling and mutation burden estimation with VarNet-T

Original source ↗

Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Nature Communications, published 2026-04-09; PMC13243554 full-text XML
Retrieved: 2026-10-11T21:37:39Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b42db521781cd548b5ce0cf99233f8e790781fb5e8953fe733202009dd8367bb

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

3 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: somatic-varnet-t-20261011-eval-deepsom-esad-seqc2-snv

areas
dna-genomes
contexts
clinical_research
origin
independent_paper
protocol
somatic-varnet-t-20261011-protocol-seqc2-snv
version
Primary source as retrieved 2026-10-11
comparison
protocol id: somatic-varnet-t-20261011-protocol-seqc2-snv; dataset version: Not reported; split: Not in VarNet-T training; population: Not reported; inputs: Tumour Illumina WGS only; adaptation: Not reported; metric implementation: AUPRC over the caller's own score; aggregation: Per sample; budget: Not reported
source locator
Supplementary Table 1, column SEQC2 SNV, row 'DeepSom-ESAD'
missing metadata
comparison.adaptation: reason: inapplicable; note: Pre-trained models; comparison.budget: reason: unreported; comparison.dataset version: reason: unreported; comparison.population: reason: unreported
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