Evaluation

Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022)

Published somatic caller comparison; transcribed, not reproduced.

Evaluation results

1 evaluation · 48 results. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	59.2% F1 (INDELs, average over the 47 purity-coverage pairs as printed) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'Average', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	49.9% F1 (INDELs, tumour SPP_100x_10%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_10%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	85.6% F1 (INDELs, tumour SPP_100x_100%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_100%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	72.4% F1 (INDELs, tumour SPP_100x_20%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_20%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	26.3% F1 (INDELs, tumour SPP_100x_5%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_5%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	83% F1 (INDELs, tumour SPP_100x_50%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_50%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	84.8% F1 (INDELs, tumour SPP_100x_75%T with normal SPP_100x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_100x_75%T vs SPP_100x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	3.6% F1 (INDELs, tumour SPP_10x_10%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_10%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	58.8% F1 (INDELs, tumour SPP_10x_100%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_100%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	13.8% F1 (INDELs, tumour SPP_10x_20%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_20%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	1.2% F1 (INDELs, tumour SPP_10x_5%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_5%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	41.3% F1 (INDELs, tumour SPP_10x_50%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_50%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	53.6% F1 (INDELs, tumour SPP_10x_75%T with normal SPP_10x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_10x_75%T vs SPP_10x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	63.2% F1 (INDELs, tumour SPP_200x_10%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_10%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	85.2% F1 (INDELs, tumour SPP_200x_100%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_100%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	76.7% F1 (INDELs, tumour SPP_200x_20%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_20%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	38.9% F1 (INDELs, tumour SPP_200x_5%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_5%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	83.1% F1 (INDELs, tumour SPP_200x_50%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_50%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	84.5% F1 (INDELs, tumour SPP_200x_75%T with normal SPP_200x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_200x_75%T vs SPP_200x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	63.8% F1 (INDELs, tumour SPP_300x_10%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_10%T vs SPP_300x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	84.4% F1 (INDELs, tumour SPP_300x_100%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_100%T vs SPP_300x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	75% F1 (INDELs, tumour SPP_300x_20%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_20%T vs SPP_300x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	44.1% F1 (INDELs, tumour SPP_300x_5%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_5%T vs SPP_300x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	82.9% F1 (INDELs, tumour SPP_300x_50%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_50%T vs SPP_300x_100%N', column 'Octopus-RF'
Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)	Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3) Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS	83.5% F1 (INDELs, tumour SPP_300x_75%T with normal SPP_300x_100%N) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Octopus-RF on SEQC2 tumour-normal titration, INDELs (Sahraeian et al. 2022) somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel Aggregation: Not reported Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample; Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Additional file 2 Table S3, INDELs section, row 'SPP_300x_75%T vs SPP_300x_100%N', column 'Octopus-RF'

Source checking is not independent reproduction. Release 2026-10-10-cbb3da59bc08.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-10-cbb3da59bc08 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified
Sample annotations are recorded: not yet verified
Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
A pinned run recipe exists: not yet verified
Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Independent validation data exist: not yet verified
Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3)

Configuration: Octopus-RF v0.7.4 (Sahraeian et al. 2022)
Protocol: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3)
Dataset: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS

origin: Author-reported evaluation
configuration: Primary source as retrieved 2026-10-10
protocol id: somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel
dataset version: Not reported
split: Held-out 50% of the high-confidence genome
population: 42 purity-coverage pairs (5, 10, 20, 50, 75 and 100% tumour at 10x, 30x, 50x, 80x, 100x, 200x and 300x, pure normal) and 5 pairs at 80x with a 95% pure normal (10-100% tumour)
inputs: Tumour and matched normal WGS BAM files (BWA-MEM)
adaptation: Not reported
metric implementation: F1 (%) of PASS calls against the SEQC2 truth set, exact match
aggregation: Per purity-coverage pair, plus the printed average over 47
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Held-out 50% of the high-confidence genome
Adaptation: Not reported
Scoring implementation: F1 (%) of PASS calls against the SEQC2 truth set, exact match

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

38 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-cbb3da59bc08
Property and statement	Original source and location	Review and provenance
Comparison: adaptation Not reported Context-only references	Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML Retrieved: 2026-10-10T06:04:11Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `78dbe540c2558585bc7537e0e6563706fdaa329b2708e5dc82b77074379b4a6e` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: adaptation Not reported Context-only references	Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2021_2592_MOESM2_ESM.pdf Retrieved: 2026-10-10T06:04:16Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `10a109d80f6f49446ea84bd9f7f6b31c20d634516c8666376ac8a8f51f3236d0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Per purity-coverage pair, plus the printed average over 47 Context-only references	Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML Retrieved: 2026-10-10T06:04:11Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `78dbe540c2558585bc7537e0e6563706fdaa329b2708e5dc82b77074379b4a6e` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Per purity-coverage pair, plus the printed average over 47 Context-only references	Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2021_2592_MOESM2_ESM.pdf Retrieved: 2026-10-10T06:04:16Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `10a109d80f6f49446ea84bd9f7f6b31c20d634516c8666376ac8a8f51f3236d0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML Retrieved: 2026-10-10T06:04:11Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `78dbe540c2558585bc7537e0e6563706fdaa329b2708e5dc82b77074379b4a6e` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2021_2592_MOESM2_ESM.pdf Retrieved: 2026-10-10T06:04:16Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `10a109d80f6f49446ea84bd9f7f6b31c20d634516c8666376ac8a8f51f3236d0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version Not reported Context-only references	Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML Retrieved: 2026-10-10T06:04:11Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `78dbe540c2558585bc7537e0e6563706fdaa329b2708e5dc82b77074379b4a6e` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version Not reported Context-only references	Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2021_2592_MOESM2_ESM.pdf Retrieved: 2026-10-10T06:04:16Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `10a109d80f6f49446ea84bd9f7f6b31c20d634516c8666376ac8a8f51f3236d0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Tumour and matched normal WGS BAM files (BWA-MEM) Context-only references	Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML Retrieved: 2026-10-10T06:04:11Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `78dbe540c2558585bc7537e0e6563706fdaa329b2708e5dc82b77074379b4a6e` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Tumour and matched normal WGS BAM files (BWA-MEM) Context-only references	Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) Original source ↗ Additional file 2 Table S3, column 'Octopus-RF', INDELs section Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 13059_2021_2592_MOESM2_ESM.pdf Retrieved: 2026-10-10T06:04:16Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `10a109d80f6f49446ea84bd9f7f6b31c20d634516c8666376ac8a8f51f3236d0` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

All evidence (JSONL) (gzip)How to read the evidence

Sources and history

Release 2026-10-10-cbb3da59bc08 · Record review: source checked

2 source records and release history

Achieving robust somatic mutation detection with deep learning models derived from reference data sets of a cancer sample · Original source · Genome Biology 23:12, published 2022-01-07; PMC8740374 full-text XML
Sahraeian et al. 2022, Additional file 2: Supplementary Tables S1-S10 (13059_2021_2592_MOESM2_ESM.pdf) · Original source · 13059_2021_2592_MOESM2_ESM.pdf

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: somatic-neusomatic-20261010-eval-sahraeian2022-octopus-rf-titration-indel

areas: dna-genomes
contexts: clinical_research
origin: author_reported
protocol: somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel
version: Primary source as retrieved 2026-10-10
comparison: protocol id: somatic-neusomatic-20261010-protocol-sahraeian2022-titration-indel; dataset version: Not reported; split: Held-out 50% of the high-confidence genome; population: 42 purity-coverage pairs (5, 10, 20, 50, 75 and 100% tumour at 10x, 30x, 50x, 80x, 100x, 200x and 300x, pure normal) and 5 pairs at 80x with a 95% pure normal (10-100% tumour); inputs: Tumour and matched normal WGS BAM files (BWA-MEM); adaptation: Not reported; metric implementation: F1 (%) of PASS calls against the SEQC2 truth set, exact match; aggregation: Per purity-coverage pair, plus the printed average over 47; budget: Not reported
source locator: Additional file 2 Table S3, column 'Octopus-RF', INDELs section
missing metadata: comparison.dataset version: reason: unreported
evidence overlap: Model identity unresolved and possibly trained on the test cell line: Methods describe Octopus-RF as filtering with 'the pretrained random forest model', while Results say the authors trained Octopus random forests on their SEQC2 training sets (Additional file 1 Figs S7-S11). The source does not say which forest produced this column. The titration libraries are not described as training data.

Related records

system: Octopus-RF v0.7.4 (Sahraeian et al. 2022)
assessment: SEQC2 HCC1395 tumour purity, coverage and normal contamination, indel F1 (Sahraeian et al. 2022 Table S3)
data: SEQC2 tumour-normal titration: HCC1395 gDNA mixed with HCC1395BL gDNA at 5-100% tumour purity, 10x-300x WGS
evaluation: Octopus-RF titration indel F1, Average
evaluation: Octopus-RF titration indel F1, SPP_100x_10%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_100x_100%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_100x_20%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_100x_5%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_100x_50%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_100x_75%T vs SPP_100x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_10%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_100%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_20%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_5%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_50%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_10x_75%T vs SPP_10x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_10%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_100%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_20%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_5%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_50%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_200x_75%T vs SPP_200x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_10%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_100%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_20%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_5%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_50%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_300x_75%T vs SPP_300x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_10%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_100%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_20%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_5%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_50%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_30x_75%T vs SPP_30x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_10%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_100%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_20%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_5%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_50%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_50x_75%T vs SPP_50x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_10%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_10%T vs SPP_80x_95%N
evaluation: Octopus-RF titration indel F1, SPP_80x_100%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_100%T vs SPP_80x_95%N
evaluation: Octopus-RF titration indel F1, SPP_80x_20%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_20%T vs SPP_80x_95%N
evaluation: Octopus-RF titration indel F1, SPP_80x_5%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_50%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_50%T vs SPP_80x_95%N
evaluation: Octopus-RF titration indel F1, SPP_80x_75%T vs SPP_80x_100%N
evaluation: Octopus-RF titration indel F1, SPP_80x_75%T vs SPP_80x_95%N

Suggest a correction