Evaluation

Strelka on DREAM Set1 SNVs (Wang et al. 2020)

Published somatic caller comparison; transcribed, not reproduced.

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Release 2026-10-09-8cc1db47c7f9 · Evidence verified: Not verified

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Evaluation results

1 evaluation · 4 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Strelka v2.7.1 (Wang et al. 2020)	Protocol: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1) Dataset: ICGC-TCGA DREAM synthetic set 1 (WGS)	2950 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Strelka on DREAM Set1 SNVs (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set1-snv Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S1 WGS SNVs', D9; dataset 'DREAM Set1'; caller 'Strelka'; column 'Count'
Configuration: Strelka v2.7.1 (Wang et al. 2020)	Protocol: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1) Dataset: ICGC-TCGA DREAM synthetic set 1 (WGS)	0.855 f1-score fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Strelka on DREAM Set1 SNVs (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set1-snv Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S1 WGS SNVs', G9; dataset 'DREAM Set1'; caller 'Strelka'; column 'F1'
Configuration: Strelka v2.7.1 (Wang et al. 2020)	Protocol: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1) Dataset: ICGC-TCGA DREAM synthetic set 1 (WGS)	0.94 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Strelka on DREAM Set1 SNVs (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set1-snv Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S1 WGS SNVs', F9; dataset 'DREAM Set1'; caller 'Strelka'; column 'Precision'
Configuration: Strelka v2.7.1 (Wang et al. 2020)	Protocol: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1) Dataset: ICGC-TCGA DREAM synthetic set 1 (WGS)	0.784 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Strelka on DREAM Set1 SNVs (Wang et al. 2020) somatic-20261009-protocol-wang2020-dream-set1-snv Aggregation: Not reported SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach; Wang et al. 2020, Supplementary Tables (somatic caller performance) · Supplementary Tables workbook sheet 'S1 WGS SNVs', E9; dataset 'DREAM Set1'; caller 'Strelka'; column 'Recall'

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Evaluation procedure

somatic-20261009-protocol-wang2020-dream-set1-snv

Configuration: Strelka v2.7.1 (Wang et al. 2020)
Protocol: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1)
Dataset: ICGC-TCGA DREAM synthetic set 1 (WGS)

origin: Independent external evaluation
configuration: Primary source as retrieved 2026-10-09
protocol id: somatic-20261009-protocol-wang2020-dream-set1-snv
dataset version: Not reported
split: Single tumour-normal pair
population: 3537 truth SNVs
inputs: Tumour-normal WGS, 27.89/27.89x normal/tumour
adaptation: Not reported
metric implementation: DREAM challenge evaluator.py
aggregation: Pooled over the whole genome of one pair
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Single tumour-normal pair
Adaptation: Not reported
Scoring implementation: DREAM challenge evaluator.py

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Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

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36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statement	Original source and location	Review and provenance
attributes.comparison.adaptation Not reported Context-only references	SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML Retrieved: 2026-10-09T20:00:37Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `5f4e6b16675a3a6587f7999792ef479a059851ea8f7a31b4a954901aced5a8b1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.adaptation Not reported Context-only references	Wang et al. 2020, Supplementary Tables (somatic caller performance) Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher Retrieved: 2026-10-09T20:00:59Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `b9b5c68c7f78ff16863f64bb414394fd7b7dcd600795532aab30e39cd8d39c81` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Pooled over the whole genome of one pair Context-only references	SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML Retrieved: 2026-10-09T20:00:37Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `5f4e6b16675a3a6587f7999792ef479a059851ea8f7a31b4a954901aced5a8b1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Pooled over the whole genome of one pair Context-only references	Wang et al. 2020, Supplementary Tables (somatic caller performance) Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher Retrieved: 2026-10-09T20:00:59Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `b9b5c68c7f78ff16863f64bb414394fd7b7dcd600795532aab30e39cd8d39c81` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML Retrieved: 2026-10-09T20:00:37Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `5f4e6b16675a3a6587f7999792ef479a059851ea8f7a31b4a954901aced5a8b1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	Wang et al. 2020, Supplementary Tables (somatic caller performance) Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher Retrieved: 2026-10-09T20:00:59Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `b9b5c68c7f78ff16863f64bb414394fd7b7dcd600795532aab30e39cd8d39c81` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version Not reported Context-only references	SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML Retrieved: 2026-10-09T20:00:37Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `5f4e6b16675a3a6587f7999792ef479a059851ea8f7a31b4a954901aced5a8b1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version Not reported Context-only references	Wang et al. 2020, Supplementary Tables (somatic caller performance) Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher Retrieved: 2026-10-09T20:00:59Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `b9b5c68c7f78ff16863f64bb414394fd7b7dcd600795532aab30e39cd8d39c81` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs Tumour-normal WGS, 27.89/27.89x normal/tumour Context-only references	SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML Retrieved: 2026-10-09T20:00:37Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `5f4e6b16675a3a6587f7999792ef479a059851ea8f7a31b4a954901aced5a8b1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs Tumour-normal WGS, 27.89/27.89x normal/tumour Context-only references	Wang et al. 2020, Supplementary Tables (somatic caller performance) Original source ↗ Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka') Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher Retrieved: 2026-10-09T20:00:59Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `b9b5c68c7f78ff16863f64bb414394fd7b7dcd600795532aab30e39cd8d39c81` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Sources and history

Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release history

SomaticCombiner: improving the performance of somatic variant calling based on evaluation tests and a consensus approach · Original source · Scientific Reports 10:12898, published 2020-07-30; PMC7393490 full-text XML
Wang et al. 2020, Supplementary Tables (somatic caller performance) · Original source · 41598_2020_69772_MOESM3_ESM.xlsx (Supplementary Tables S1-S9) as served by the publisher

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Technical metadata and extraction receipts

Stable ID: somatic-20261009-eval-wang2020-strelka-dream-set1-snv

areas: dna-genomes
contexts: clinical_research
origin: independent_paper
protocol: somatic-20261009-protocol-wang2020-dream-set1-snv
version: Primary source as retrieved 2026-10-09
comparison: protocol id: somatic-20261009-protocol-wang2020-dream-set1-snv; dataset version: Not reported; split: Single tumour-normal pair; population: 3537 truth SNVs; inputs: Tumour-normal WGS, 27.89/27.89x normal/tumour; adaptation: Not reported; metric implementation: DREAM challenge evaluator.py; aggregation: Pooled over the whole genome of one pair; budget: Not reported
source locator: Supplementary Tables workbook sheet 'S1 WGS SNVs', row 9 (dataset 'DREAM Set1', caller 'Strelka')
missing metadata: comparison.dataset version: reason: unreported

Related records

system: Strelka v2.7.1 (Wang et al. 2020)
assessment: DREAM synthetic set 1 somatic SNVs, WGS (Wang et al. 2020 Table S1)
data: ICGC-TCGA DREAM synthetic set 1 (WGS)
evaluation: wang2020-strelka-dream-set1-snv count (snv only)
evaluation: wang2020-strelka-dream-set1-snv f1-score (snv only)
evaluation: wang2020-strelka-dream-set1-snv precision (snv only)
evaluation: wang2020-strelka-dream-set1-snv recall (snv only)

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