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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Talos 8.2.0, proband-only mode on trio cases (Kaschta et al. 2026) | Protocol: Talos recovery of known P/LP and VUS variants in 162 trio cases (Kaschta et al. 2026) Dataset: UKSH trio benchmarking cases with known findings (Kaschta et al. 2026) | 82.8% Recall (known P/LP variants prioritised, proband-only mode) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceTalos in proband-only mode on 162 trio benchmarking cases reanalysis-kaschta-20261010-protocol-talos-trio-benchmark Aggregation: Not reported Automated versus manual reanalysis in rare disease genomics · Results, Benchmarking of Automated Reanalysis: Trio Cases P3, 'increasing concordance to 82.8%' |
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Talos recovery of known P/LP and VUS variants in 162 trio cases (Kaschta et al. 2026)
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18 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation No manual curation Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: aggregation Pooled over variants Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: budget Not reported Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | missing or unspecified No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: dataset version UKSH cohort as published Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: inputs Archived DRAGEN v3.7.5 VCFs, proband only Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: metric implementation Per-variant tracking against the initial report Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: population 145 P/LP variants in 162 trio cases Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: protocol id reanalysis-kaschta-20261010-protocol-talos-trio-benchmark Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Comparison: split No split Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
| Origin independent_paper Context-only references | Automated versus manual reanalysis in rare disease genomics Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3 Version: medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML | not individually reviewed No individual claim review recorded independent paper Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of the JATS source XML as returned on 2026-10-10. |
Release 2026-10-10-457d7eaef7d6 · Record review: source checked
Stable ID: reanalysis-kaschta-20261010-eval-talos-trio-benchmark-proband-only