Configuration

Talos 8.2.0, proband-only mode on trio cases (Kaschta et al. 2026)

Talos 8.2.0, proband-only mode on trio cases (Kaschta et al. 2026) as run in Kaschta et al. 2026.

Overview

Talos: Inheritance-aware genomic variant prioritization and iterative reanalysis.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Talos 8.2.0, proband-only mode on trio cases (Kaschta et al. 2026)	Protocol: Talos recovery of known P/LP and VUS variants in 162 trio cases (Kaschta et al. 2026) Dataset: UKSH trio benchmarking cases with known findings (Kaschta et al. 2026)	82.8% Recall (known P/LP variants prioritised, proband-only mode) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Talos in proband-only mode on 162 trio benchmarking cases reanalysis-kaschta-20261010-protocol-talos-trio-benchmark Aggregation: Not reported Automated versus manual reanalysis in rare disease genomics · Results, Benchmarking of Automated Reanalysis: Trio Cases P3, 'increasing concordance to 82.8%'

Source checking is not independent reproduction. Release 2026-10-10-cbb3da59bc08.

Use this configuration

How it works, versions and access

Strengths, limitations and unresolved questions

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

0 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-cbb3da59bc08
Property and statement	Original source and location	Review and provenance

No evidence rows match these filters. Choose another scope or clear the search.

All evidence (JSONL) (gzip)How to read the evidence

Sources and history

Release 2026-10-10-cbb3da59bc08 · Record review: source checked

1 source record and release history

Automated versus manual reanalysis in rare disease genomics · Original source · medRxiv 2026.05.16.26352295 v1, posted 2026-05-19; JATS source XML

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: reanalysis-kaschta-20261010-config-talos-8-2-0-proband-only

areas: dna-genomes
contexts: clinical_research
method types: conventional_pipeline
reported name: Talos (proband-only mode)
foundation model eligible: false
version: 8.2.0
parameters: As the archived-VCF configuration, run without parental genotypes
source locator: Results 'Benchmarking of Automated Reanalysis: Trio Cases' P3

Related records

configuration of: Talos
system: Talos in proband-only mode on 162 trio benchmarking cases

Suggest a correction