rewirebio.iobenchmarks
Evaluation

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

Published pipeline execution benchmark; transcribed, not reproduced.

Evaluation results

1 evaluation · 5 results. Different protocols are not a single leaderboard.

Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1) · Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)

Sorted by Runtime (Germline FASTQ to VCF; human WGS at 100x average depth) (lower is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationRuntime (Germline FASTQ to VCF; human WGS at 100x average depth)Runtime (Germline FASTQ to VCF; human WGS at 30x average depth)Runtime (Germline FASTQ to VCF; human WGS at 40x average depth)Runtime (Germline FASTQ to VCF; human WGS at 50x average depth)Runtime (Germline FASTQ to VCF; human WGS at 60x average depth)
Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Evaluation2h 06m30m42m1h 00m1h 12m
All 5 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
2h 06m Runtime (Germline FASTQ to VCF; human WGS at 100x average depth)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth

Aggregation: Not reported

GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis; GeNePi: Supplementary Information · Supplementary Table S1 (page 7), row 'Avg. Reads Depth' 100x, column 'GPU-4xA100'
Configuration: Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
30m Runtime (Germline FASTQ to VCF; human WGS at 30x average depth)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth

Aggregation: Not reported

GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis; GeNePi: Supplementary Information · Supplementary Table S1 (page 7), row 'Avg. Reads Depth' 30x, column 'GPU-4xA100'
Configuration: Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
42m Runtime (Germline FASTQ to VCF; human WGS at 40x average depth)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth

Aggregation: Not reported

GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis; GeNePi: Supplementary Information · Supplementary Table S1 (page 7), row 'Avg. Reads Depth' 40x, column 'GPU-4xA100'
Configuration: Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
1h 00m Runtime (Germline FASTQ to VCF; human WGS at 50x average depth)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth

Aggregation: Not reported

GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis; GeNePi: Supplementary Information · Supplementary Table S1 (page 7), row 'Avg. Reads Depth' 50x, column 'GPU-4xA100'
Configuration: Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)Protocol: Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset: Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
1h 12m Runtime (Germline FASTQ to VCF; human WGS at 60x average depth)
minute · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs, runtime by depth (Marangoni et al. 2026)

model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth

Aggregation: Not reported

GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis; GeNePi: Supplementary Information · Supplementary Table S1 (page 7), row 'Avg. Reads Depth' 60x, column 'GPU-4xA100'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)

Configuration
Parabricks germline v4.3.0 (GeNePi PB_germ) on 4 A100 GPUs (Marangoni et al. 2026)
Protocol
Germline FASTQ-to-VCF runtime by read depth, Parabricks v4.3.0 on V100 and A100 GPUs versus the CPU GATK equivalent (Marangoni et al. 2026 Table S1)
Dataset
Human WGS paired-end data at 30x, 40x, 50x, 60x and 100x average depth (Marangoni et al. 2026 Table S1)
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth
dataset version
Not reported
split
Five average depths, one value each; number of runs not stated
population
Human WGS at 30x to 100x
inputs
Paired-end FASTQ
adaptation
Not reported
metric implementation
Not reported
aggregation
One value per depth
budget
Number of runs not stated; no fixed hardware budget, hardware is part of each configuration

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Five average depths, one value each; number of runs not stated
Adaptation
Not reported
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Not reported
Context-only references
GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Briefings in Bioinformatics 27(1), published 2026-01-25; PMC12832024 full-text XML
Retrieved: 2026-10-11T21:42:44Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 6251ae2946d56aff88ef3d11b717a3583f1c18ed45eef9064931f155ab6964e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: adaptation
Not reported
Context-only references
GeNePi: Supplementary Information

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: genepi_supplinfo_rev_bbag001.pdf from the Europe PMC supplementary files of PMC12832024
Retrieved: 2026-10-11T21:42:45Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: afa166a30320efd633cb28ddc91a05082854b0ef5e6593333c0ce9dbd2ae1bb9

Hash scope: Hash scope not separately documented; inspect source record

Archive member: genepi_supplinfo_rev_bbag001.pdf

Inspected artifact

Comparison: aggregation
One value per depth
Context-only references
GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Briefings in Bioinformatics 27(1), published 2026-01-25; PMC12832024 full-text XML
Retrieved: 2026-10-11T21:42:44Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 6251ae2946d56aff88ef3d11b717a3583f1c18ed45eef9064931f155ab6964e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: aggregation
One value per depth
Context-only references
GeNePi: Supplementary Information

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: genepi_supplinfo_rev_bbag001.pdf from the Europe PMC supplementary files of PMC12832024
Retrieved: 2026-10-11T21:42:45Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: afa166a30320efd633cb28ddc91a05082854b0ef5e6593333c0ce9dbd2ae1bb9

Hash scope: Hash scope not separately documented; inspect source record

Archive member: genepi_supplinfo_rev_bbag001.pdf

Inspected artifact

Comparison: budget
Number of runs not stated; no fixed hardware budget, hardware is part of each configuration
Context-only references
GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Briefings in Bioinformatics 27(1), published 2026-01-25; PMC12832024 full-text XML
Retrieved: 2026-10-11T21:42:44Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 6251ae2946d56aff88ef3d11b717a3583f1c18ed45eef9064931f155ab6964e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: budget
Number of runs not stated; no fixed hardware budget, hardware is part of each configuration
Context-only references
GeNePi: Supplementary Information

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: genepi_supplinfo_rev_bbag001.pdf from the Europe PMC supplementary files of PMC12832024
Retrieved: 2026-10-11T21:42:45Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: afa166a30320efd633cb28ddc91a05082854b0ef5e6593333c0ce9dbd2ae1bb9

Hash scope: Hash scope not separately documented; inspect source record

Archive member: genepi_supplinfo_rev_bbag001.pdf

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Briefings in Bioinformatics 27(1), published 2026-01-25; PMC12832024 full-text XML
Retrieved: 2026-10-11T21:42:44Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 6251ae2946d56aff88ef3d11b717a3583f1c18ed45eef9064931f155ab6964e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
GeNePi: Supplementary Information

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: genepi_supplinfo_rev_bbag001.pdf from the Europe PMC supplementary files of PMC12832024
Retrieved: 2026-10-11T21:42:45Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: afa166a30320efd633cb28ddc91a05082854b0ef5e6593333c0ce9dbd2ae1bb9

Hash scope: Hash scope not separately documented; inspect source record

Archive member: genepi_supplinfo_rev_bbag001.pdf

Inspected artifact

Comparison: inputs
Paired-end FASTQ
Context-only references
GeNePi: a graphics processing unit enhanced next-generation bioinformatics pipeline for whole-genome sequencing analysis

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Briefings in Bioinformatics 27(1), published 2026-01-25; PMC12832024 full-text XML
Retrieved: 2026-10-11T21:42:44Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 6251ae2946d56aff88ef3d11b717a3583f1c18ed45eef9064931f155ab6964e6

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Comparison: inputs
Paired-end FASTQ
Context-only references
GeNePi: Supplementary Information

Original source ↗

Supplementary Table S1 column 'GPU-4xA100'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: genepi_supplinfo_rev_bbag001.pdf from the Europe PMC supplementary files of PMC12832024
Retrieved: 2026-10-11T21:42:45Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: afa166a30320efd633cb28ddc91a05082854b0ef5e6593333c0ce9dbd2ae1bb9

Hash scope: Hash scope not separately documented; inspect source record

Archive member: genepi_supplinfo_rev_bbag001.pdf

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: model-execution-20261011-eval-marangoni2026-parabricks-4-3-0-4xa100

areas
dna-genomes
contexts
clinical_research
origin
author_reported
protocol
model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth
version
Primary source as retrieved 2026-10-11
comparison
protocol id: model-execution-20261011-protocol-marangoni2026-germline-runtime-by-depth; dataset version: Not reported; split: Five average depths, one value each; number of runs not stated; population: Human WGS at 30x to 100x; inputs: Paired-end FASTQ; adaptation: Not reported; metric implementation: Not reported; aggregation: One value per depth; budget: Number of runs not stated; no fixed hardware budget, hardware is part of each configuration
source locator
Supplementary Table S1 column 'GPU-4xA100'
missing metadata
comparison.dataset version: reason: unreported; comparison.metric implementation: reason: unreported; note: How execution time was measured is not stated
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