rewirebio.iobenchmarks
Evaluation

Chai-1 on LiPP test set (lipid pose all-atom RMSD below 2 Angstrom)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Chai-1 (LiPP evaluation)Protocol: LiPP Table 2: lipid pose all-atom RMSD below 2 Angstrom, LiPP test set
Dataset: LiPP test set (36 complexes released after every tool's cutoff)
36.1 {20.8–53.7}% Ligand RMSD under 2a rate (lipid pose all-atom RMSD below 2 Angstrom; LiPP test set)
percent · higher

Uncertainty: 95% CI 20.8 to 53.7. Exact binomial interval (table footnote a: 'lower and upper bounds of the 95% confidence intervals calculated with exact binomial distribution')

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Chai-1 on LiPP test set (lipid pose all-atom RMSD below 2 Angstrom)

lit-structure-20261011-lipp-protocol-rmsd-lipp-test-36

Aggregation: Not reported

The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods · Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

LiPP Table 2: lipid pose all-atom RMSD below 2 Angstrom, LiPP test set

Configuration
Chai-1 (LiPP evaluation)
Protocol
LiPP Table 2: lipid pose all-atom RMSD below 2 Angstrom, LiPP test set
Dataset
LiPP test set (36 complexes released after every tool's cutoff)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
lit-structure-20261011-lipp-protocol-rmsd-lipp-test-36
dataset version
Not reported
split
LiPP test set
population
36 complexes
inputs
Protein sequence or structure and the bound lipid or small molecule
adaptation
None; tools run as released
metric implementation
lipid pose all-atom RMSD below 2 Angstrom
aggregation
Share of complexes counted as successful
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
LiPP test set
Adaptation
None; tools run as released
Scoring implementation
lipid pose all-atom RMSD below 2 Angstrom

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
None; tools run as released
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: aggregation
Share of complexes counted as successful
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: budget
Not reported
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: inputs
Protein sequence or structure and the bound lipid or small molecule
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: metric implementation
lipid pose all-atom RMSD below 2 Angstrom
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: population
36 complexes
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: protocol id
lit-structure-20261011-lipp-protocol-rmsd-lipp-test-36
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: split
LiPP test set
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Origin
independent_paper
Context-only references
The LiPP Benchmark Set for Modeling Lipid–Protein Complexes: Comparison of Co-Folding and Docking Methods

Original source ↗

Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'

Version: PMC13292216.1
Retrieved: 2026-09-17T07:56:27.507412+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: 6ff34f2f709a14858a3753abf9f8f6efa1e7e3c351f15c70cf64264193a9414e

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-structure-20261011-lipp-eval-rmsd-lipp-test-36-chai-1

areas
protein-structure; molecular-interactions
contexts
research
origin
independent_paper
protocol
lit-structure-20261011-lipp-protocol-rmsd-lipp-test-36
version
Primary source as retrieved 2026-10-11
comparison
protocol id: lit-structure-20261011-lipp-protocol-rmsd-lipp-test-36; dataset version: Not reported; split: LiPP test set; population: 36 complexes; inputs: Protein sequence or structure and the bound lipid or small molecule; adaptation: None; tools run as released; metric implementation: lipid pose all-atom RMSD below 2 Angstrom; aggregation: Share of complexes counted as successful; budget: Not reported
source locator
Table 2, row 'Chai-1', column 'LiPP test set (N = 36) % Success Rate'
missing metadata
comparison.budget: reason: unreported; comparison.dataset version: reason: unreported
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