Evaluation

AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (Aptamer)

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)	Protocol: RNAGym v0.1.1 fitness, signed Spearman, Aptamer Dataset: RNAGym Aptamer DMS assays (2)	0.0624 Spearman (mean signed Spearman over the 2 Aptamer assays) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source AIDO.RNA-1M-MARS on RNAGym v0.1.1 fitness (Aptamer) lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer Aggregation: Not reported RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified
Sample annotations are recorded: not yet verified
Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
A pinned run recipe exists: not yet verified
Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Independent validation data exist: not yet verified
Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

RNAGym v0.1.1 fitness, signed Spearman, Aptamer

Configuration: AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)
Protocol: RNAGym v0.1.1 fitness, signed Spearman, Aptamer
Dataset: RNAGym Aptamer DMS assays (2)

origin: Independent external evaluation
configuration: Primary source as retrieved 2026-10-11
protocol id: lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer
dataset version: RNAGym v0.1.1
split: Whole assays (zero-shot)
population: Not reported
inputs: Wild-type and variant RNA sequences
adaptation: Zero-shot; masked-marginal log-likelihood ratio for masked language models
metric implementation: Signed Spearman (performance_fitness.py --type ncRNA on branch v0.2)
aggregation: Mean over assays in the category
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: Whole assays (zero-shot)
Adaptation: Zero-shot; masked-marginal log-likelihood ratio for masked language models
Scoring implementation: Signed Spearman (performance_fitness.py --type ncRNA on branch v0.2)

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Comparison: adaptation Zero-shot; masked-marginal log-likelihood ratio for masked language models Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: aggregation Mean over assays in the category Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: budget Not reported Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: dataset version RNAGym v0.1.1 Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: inputs Wild-type and variant RNA sequences Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: metric implementation Signed Spearman (performance_fitness.py --type ncRNA on branch v0.2) Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.metric_implementation` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: population Not reported Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	missing or unspecified No individual claim review recorded independent paper Audit details Field: `attributes.comparison.population` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: protocol id lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.protocol_id` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison: split Whole assays (zero-shot) Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.comparison.split` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 1 values Run by the RNAGym maintainers with their scoring scripts, not by the model developers. Context-only references	RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md Original source ↗ leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer' Version: Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1 Retrieved: 2026-10-11T21:40:04Z	not individually reviewed No individual claim review recorded independent paper Audit details Field: `attributes.limitations` Source artifact SHA-256: `c947a7a45a53cc4106323a3bcae1bb3fa84276bc07df89493cb501735711b891` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md · Original source · Commit 2828cf99316d75daaa8d832a2573cbb25bbd35fe (2026-08-14, 'Update fitness leaderboard v0.2 models'); leaderboard labelled v0.1.1

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: lit-rna-20261011-rnagym-eval-aido-rna-1m-mars-aptamer

areas: rna-transcriptomes
contexts: research
origin: independent_paper
protocol: lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer
version: Primary source as retrieved 2026-10-11
comparison: protocol id: lit-rna-20261011-rnagym-protocol-signed-spearman-aptamer; dataset version: RNAGym v0.1.1; split: Whole assays (zero-shot); population: Not reported; inputs: Wild-type and variant RNA sequences; adaptation: Zero-shot; masked-marginal log-likelihood ratio for masked language models; metric implementation: Signed Spearman (performance_fitness.py --type ncRNA on branch v0.2); aggregation: Mean over assays in the category; budget: Not reported
source locator: leaderboard/fitness/README.md, 'AIDO.RNA across model sizes' table, row 'AIDO.RNA-1M-MARS', column 'Aptamer'
missing metadata: comparison.budget: reason: unreported; comparison.population: reason: unreported
limitations: Run by the RNAGym maintainers with their scoring scripts, not by the model developers.

Related records

system: AIDO.RNA-1M-MARS (RNAGym fitness leaderboard v0.1.1)
assessment: RNAGym v0.1.1 fitness, signed Spearman, Aptamer
data: RNAGym Aptamer DMS assays (2)
evaluation: AIDO.RNA-1M-MARS RNAGym Aptamer signed Spearman

Suggest a correction