rewirebio.iobenchmarks
Evaluation

CPA ∗ on PerturBench v4 frangieh21

Published comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 7 results. Different protocols are not a single leaderboard.

Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21 · Dataset subset: Frangieh21 (PerturBench v4 co-culture split)

Sorted by Perturbench cosine logfc (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationPerturbench cosine logfcPerturbench cosine logfc rankPerturbench energy mmd (gene expression space)Perturbench energy mmd (PCA space: top 256 principal components fitted on the ground-truth test split)Perturbench RMSE of meanPerturbench RMSE rankRecall (DEG recall: fraction of the top 20 ground-truth DEGs (scanpy t-scores against controls) recalled from predicted cells)
CPA*Evaluation0.10 ± 7 × 10 − 30.30 ± 3 × 10 − 22.1 ± 2 × 10 − 20.26 ± 5 × 10 − 30.027 ± 1 × 10 − 40.28 ± 1 × 10 − 20.000 ± 0
All 7 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.30 ± 3 × 10 − 2 Perturbench cosine logfc rank
fraction · lower

Uncertainty: SD 0.03

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 7, row 'CPA ∗', column 'Cosine LogFC rank'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.10 ± 7 × 10 − 3 Perturbench cosine logfc
fraction · higher

Uncertainty: SD 0.007

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 7, row 'CPA ∗', column 'Cosine logFC'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.000 ± 0 Recall (DEG recall: fraction of the top 20 ground-truth DEGs (scanpy t-scores against controls) recalled from predicted cells)
fraction · higher

Uncertainty: SD 0

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 7, row 'CPA ∗', column 'DEG recall'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.26 ± 5 × 10 − 3 Perturbench energy mmd (PCA space: top 256 principal components fitted on the ground-truth test split)
unit-unreported · lower

Uncertainty: SD 0.005

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 7, row 'CPA ∗', column 'MMD PCA'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
2.1 ± 2 × 10 − 2 Perturbench energy mmd (gene expression space)
unit-unreported · lower

Uncertainty: SD 0.02

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 8, row 'CPA ∗', column 'MMD'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.28 ± 1 × 10 − 2 Perturbench RMSE rank
fraction · lower

Uncertainty: SD 0.01

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 8, row 'CPA ∗', column 'RMSE mean rank'
Configuration: CPA*Protocol: PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset: Frangieh21 (PerturBench v4 co-culture split)
0.027 ± 1 × 10 − 4 Perturbench RMSE of mean
unit-unreported · lower

Uncertainty: SD 0.0001

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

CPA ∗ on PerturBench v4 frangieh21

lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21

Aggregation: Not reported

PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4) · Table 8, row 'CPA ∗', column 'RMSE mean'

Source checking is not independent reproduction. Release 2026-10-23-5347695500ed.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-23-5347695500ed · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21

Configuration
CPA*
Protocol
PerturBench v4 covariate transfer from mono-culture to co-culture on Frangieh21
Dataset subset
Frangieh21 (PerturBench v4 co-culture split)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-11
protocol id
lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21
dataset version
Not reported
split
Frangieh21 genetic perturbations in melanoma cells; 70% of perturbations in the co-culture condition held out.
population
Not reported
inputs
Control cells with matched covariates and perturbation identity
adaptation
Trained from scratch per dataset with HPO
metric implementation
PerturBench evaluation module (Section 4.2)
aggregation
Mean over 5 seeds
budget
Optuna HPO, at least 60 trials

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Frangieh21 genetic perturbations in melanoma cells; 70% of perturbations in the co-culture condition held out.
Adaptation
Trained from scratch per dataset with HPO
Scoring implementation
PerturBench evaluation module (Section 4.2)

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-23-5347695500ed
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Trained from scratch per dataset with HPO
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: aggregation
Mean over 5 seeds
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: budget
Optuna HPO, at least 60 trials
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: inputs
Control cells with matched covariates and perturbation identity
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: metric implementation
PerturBench evaluation module (Section 4.2)
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: population
Not reported
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: protocol id
lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Comparison: split
Frangieh21 genetic perturbations in melanoma cells; 70% of perturbations in the co-culture condition held out.
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

Origin
independent_paper
Context-only references
PerturBench: Benchmarking Machine Learning Models for Cellular Perturbation Analysis (arXiv v4)

Original source ↗

Table 7, row 'CPA ∗'

Version: arXiv 2408.10609v4, posted 2025-10-24 (NeurIPS 2025 Datasets and Benchmarks Track version)
Retrieved: 2026-10-11T21:29:35Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: b73f2644b129ca209b69812ad467d595e15c283f6cae5c3c9bbc5a4c5870996a

Hash scope: Exact bytes of the arXiv HTML rendering of v4 as retrieved; arXiv may regenerate HTML, so the hash describes this retrieval.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-23-5347695500ed · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: lit-cells-networks-20261011-perturbench-v4-eval-frangieh21-cpa

areas
single-cell
contexts
research
origin
independent_paper
protocol
lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21
version
Primary source as retrieved 2026-10-11
comparison
protocol id: lit-cells-networks-20261011-perturbench-v4-protocol-frangieh21; dataset version: Not reported; split: Frangieh21 genetic perturbations in melanoma cells; 70% of perturbations in the co-culture condition held out.; population: Not reported; inputs: Control cells with matched covariates and perturbation identity; adaptation: Trained from scratch per dataset with HPO; metric implementation: PerturBench evaluation module (Section 4.2); aggregation: Mean over 5 seeds; budget: Optuna HPO, at least 60 trials
source locator
Table 7, row 'CPA ∗'
missing metadata
comparison.dataset version: reason: unreported; comparison.population: reason: unreported
Related records

Suggest a correction