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1 evaluation · 1 result. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Boltz-2 pIC50 (Kim, Correy, Hall et al. 2026 hit-list re-ranking) | Protocol: Re-ranking the Sigma-2 receptor docking hit list by co-folding and docking scores (Kim, Correy, Hall et al. 2026) Dataset: Sigma-2 receptor docking hit list, 506 tested compounds | AUC = 83.8 AUROC (Discrimination of measured binders from high-ranking docking false positives in the tested sigma-2 receptor hit list) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBoltz-2 pIC50 re-ranking the sigma-2 receptor docking hit list (Kim, Correy, Hall et al. 2026) hitdisc-20261022-protocol-kim-sigma2 Aggregation: Not reported Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) · Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset; printed in the body text as 'AUC = 83.8' |
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19 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Comparison: adaptation None; pretrained models and the published docking receptor Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: aggregation Pooled over the compounds of one target's tested list Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: budget Not reported Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | missing or unspecified No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: dataset version Tested compounds and measured potencies as provided in Supplementary file 5 Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: inputs Ligand SMILES and the protein sequence for the co-folding scores; the ligand SMILES and the receptor structure for DOCK3.7 Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: metric implementation Area under the receiver operating characteristic curve for separating true hits from non-binders, printed as a percentage Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: population 506 tested compounds from a 490-million molecule screen: 201 true hits and 305 non-binders Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: protocol id hitdisc-20261022-protocol-kim-sigma2 Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Comparison: split Whole tested list; no training or test split applies Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Interpretation The compounds were all synthesised and assayed, but the score comparison is a retrospective re-ranking of that tested set rather than a new prospective screen. Context-only references | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | not individually reviewed No individual claim review recorded author reported Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: hitdisc-20261022-eval-kim-sigma2-kim-boltz2-pic50