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Evaluation

Caduceus-Ph G.Subterraneus 4mC evaluation

Caduceus-Ph G.Subterraneus 4mC sequence-classification evaluation; Feng et al. 2025. Transcribed, not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Caduceus-Ph (G.Subterraneus 4mC classification)Protocol: Feng G.Subterraneus 4mC sequence classification
Dataset: Feng G.Subterraneus 4mC dataset
0.608 AUROC (task: g.subterraneus 4mc)
unitless · higher

Uncertainty: Not reported by the source: Table 3 prints point AUCs only.

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

Caduceus-Ph G.Subterraneus 4mC evaluation

Table 3, frozen embeddings + task-specific random forest classifier

Aggregation: Not reported

Benchmarking DNA foundation models for genomic and genetic tasks · Table 3, row 'G.Subterraneus 4mC', column 'Caduceus-Ph'.

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

Table 3, frozen embeddings + task-specific random forest classifier

Configuration
Caduceus-Ph (G.Subterraneus 4mC classification)
Protocol
Feng G.Subterraneus 4mC sequence classification
Dataset
Feng G.Subterraneus 4mC dataset
origin
Independent external evaluation
configuration
Not reported
adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact task
aggregation
Not reported
budget
Not reported
dataset version
Not reported
inputs
DNA sequence windows for G.Subterraneus 4mC classification
metric implementation
Not reported
population
N4-methylcytosine (4mC) site detection benchmark, G. subterraneus set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6.
protocol id
feng-dna-fm-20261014-protocol-t3-g-subterraneus-4mc
split
Original predefined split retained where clearly defined; otherwise a random 70:30 train/test split. DNABERT-2/NT-v2 benchmark datasets are re-split 70:30 keeping class proportions. Random forest hyperparameters tuned by fivefold cross-validation. No whole-chromosome holdout (Methods, 'Sequence classification benchmark'). Supplementary Data 6: 63567 training and 27243 test sequences.

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Original predefined split retained where clearly defined; otherwise a random 70:30 train/test split. DNABERT-2/NT-v2 benchmark datasets are re-split 70:30 keeping class proportions. Random forest hyperparameters tuned by fivefold cross-validation. No whole-chromosome holdout (Methods, 'Sequence classification benchmark'). Supplementary Data 6: 63567 training and 27243 test sequences.
Adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact task
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

16 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact task
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: budget
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: inputs
DNA sequence windows for G.Subterraneus 4mC classification
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: metric implementation
Not reported
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: population
N4-methylcytosine (4mC) site detection benchmark, G. subterraneus set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6.
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: protocol id
feng-dna-fm-20261014-protocol-t3-g-subterraneus-4mc
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Comparison: split
Original predefined split retained where clearly defined; otherwise a random 70:30 train/test split. DNABERT-2/NT-v2 benchmark datasets are re-split 70:30 keeping class proportions. Random forest hyperparameters tuned by fivefold cross-validation. No whole-chromosome holdout (Methods, 'Sequence classification benchmark'). Supplementary Data 6: 63567 training and 27243 test sequences.
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

Origin
independent_paper
Context-only references
Benchmarking DNA foundation models for genomic and genetic tasks

Original source ↗

No field-specific location recorded

Version: PMC12663285.1
Retrieved: 2026-09-17T07:54:51.004119+00:00

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.origin

Source artifact SHA-256: 5d8ca9bcf88cc1b38ad667906a2e4699b1aefa6d31c6f49259784930353f3202

Hash scope: Exact retrieved primary paper artifact bytes.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: feng-dna-fm-20261014-eval-t3-g-subterraneus-4mc-caduceus-ph

areas
dna-genomes
contexts
research
origin
independent_paper
protocol
Table 3, frozen embeddings + task-specific random forest classifier
comparison
adaptation: Frozen pretrained representation plus a supervised random-forest classifier head fitted for this exact task; aggregation: Not reported; budget: Not reported; dataset version: Not reported; inputs: DNA sequence windows for G.Subterraneus 4mC classification; metric implementation: Not reported; population: N4-methylcytosine (4mC) site detection benchmark, G. subterraneus set of six species datasets; 41 bp sequences centred on potential 4mC sites (Methods, 'Sequence classification datasets', 4mC site detection in multiple species; Supplementary Note 1 (Supplementary Information pages 1-2)); sequence length median 41 bp (range 41-41 bp) per Supplementary Data 6.; protocol id: feng-dna-fm-20261014-protocol-t3-g-subterraneus-4mc; split: Original predefined split retained where clearly defined; otherwise a random 70:30 train/test split. DNABERT-2/NT-v2 benchmark datasets are re-split 70:30 keeping class proportions. Random forest hyperparameters tuned by fivefold cross-validation. No whole-chromosome holdout (Methods, 'Sequence classification benchmark'). Supplementary Data 6: 63567 training and 27243 test sequences.
missing metadata
budget: reason: unextracted; note: Not extracted; no execution; metric implementation: reason: unreported; note: Exact scoring implementation beyond AUC is unreported.; version: reason: unextracted
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