| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.53 accuracy fraction · higher Uncertainty: Not reported by the source Coverage: 239 cancer patients scored (n printed in cell B19) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C19; Validation block; row 'All cancer'; column 'RF' under 'All stage' (n in B19) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.79 recall fraction · higher Uncertainty: Not reported by the source Coverage: 67 cancer patients scored (n printed in cell B14) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C14; Validation block; row 'Breast'; column 'RF' under 'All stage' (n in B14) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.38 recall fraction · higher Uncertainty: Not reported by the source Coverage: 53 cancer patients scored (n printed in cell B15) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C15; Validation block; row 'CRC'; column 'RF' under 'All stage' (n in B15) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.6 recall fraction · higher Uncertainty: Not reported by the source Coverage: 5 cancer patients scored (n printed in cell F15) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G15; Validation block; row 'CRC'; column 'RF' under 'Stage I' (n in F15) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.3 recall fraction · higher Uncertainty: Not reported by the source Coverage: 20 cancer patients scored (n printed in cell J15) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K15; Validation block; row 'CRC'; column 'RF' under 'Stage II' (n in J15) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.45 recall fraction · higher Uncertainty: Not reported by the source Coverage: 20 cancer patients scored (n printed in cell N15) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O15; Validation block; row 'CRC'; column 'RF' under 'Stage III' (n in N15) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.25 recall fraction · higher Uncertainty: Not reported by the source Coverage: 8 cancer patients scored (n printed in cell R15) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S15; Validation block; row 'CRC'; column 'RF' under 'Non-metastasis with unknown stage' (n in R15) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.19 recall fraction · higher Uncertainty: Not reported by the source Coverage: 31 cancer patients scored (n printed in cell B16) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C16; Validation block; row 'Gastric'; column 'RF' under 'All stage' (n in B16) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 1 recall fraction · higher Uncertainty: Not reported by the source Coverage: 2 cancer patients scored (n printed in cell F16) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G16; Validation block; row 'Gastric'; column 'RF' under 'Stage I' (n in F16) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.4 recall fraction · higher Uncertainty: Not reported by the source Coverage: 5 cancer patients scored (n printed in cell J16) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K16; Validation block; row 'Gastric'; column 'RF' under 'Stage II' (n in J16) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.2 recall fraction · higher Uncertainty: Not reported by the source Coverage: 10 cancer patients scored (n printed in cell N16) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O16; Validation block; row 'Gastric'; column 'RF' under 'Stage III' (n in N16) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0 recall fraction · higher Uncertainty: Not reported by the source Coverage: 14 cancer patients scored (n printed in cell R16) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S16; Validation block; row 'Gastric'; column 'RF' under 'Non-metastasis with unknown stage' (n in R16) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.62 recall fraction · higher Uncertainty: Not reported by the source Coverage: 45 cancer patients scored (n printed in cell B17) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C17; Validation block; row 'Liver'; column 'RF' under 'All stage' (n in B17) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 1 recall fraction · higher Uncertainty: Not reported by the source Coverage: 2 cancer patients scored (n printed in cell F17) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G17; Validation block; row 'Liver'; column 'RF' under 'Stage I' (n in F17) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.7 recall fraction · higher Uncertainty: Not reported by the source Coverage: 10 cancer patients scored (n printed in cell J17) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K17; Validation block; row 'Liver'; column 'RF' under 'Stage II' (n in J17) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.6 recall fraction · higher Uncertainty: Not reported by the source Coverage: 15 cancer patients scored (n printed in cell N17) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O17; Validation block; row 'Liver'; column 'RF' under 'Stage III' (n in N17) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.56 recall fraction · higher Uncertainty: Not reported by the source Coverage: 18 cancer patients scored (n printed in cell R17) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S17; Validation block; row 'Liver'; column 'RF' under 'Non-metastasis with unknown stage' (n in R17) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.44 recall fraction · higher Uncertainty: Not reported by the source Coverage: 43 cancer patients scored (n printed in cell B18) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C18; Validation block; row 'Lung'; column 'RF' under 'All stage' (n in B18) |
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| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | N/A recall fraction · higher Uncertainty: Not reported by the source Coverage: 0 cancer patients scored (n printed in cell F18) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G18; Validation block; row 'Lung'; column 'RF' under 'Stage I' (n in F18) |
|---|
| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.33 recall fraction · higher Uncertainty: Not reported by the source Coverage: 3 cancer patients scored (n printed in cell J18) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K18; Validation block; row 'Lung'; column 'RF' under 'Stage II' (n in J18) |
|---|
| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.42 recall fraction · higher Uncertainty: Not reported by the source Coverage: 24 cancer patients scored (n printed in cell N18) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O18; Validation block; row 'Lung'; column 'RF' under 'Stage III' (n in N18) |
|---|
| Configuration: SPOT-MAS tissue-of-origin Random forest (RF) | Protocol: SPOT-MAS five-class tissue of origin, independent validation cohort Dataset: SPOT-MAS validation cohort, 239 non-metastatic cancer patients (five cancer types) | 0.5 recall fraction · higher Uncertainty: Not reported by the source Coverage: 16 cancer patients scored (n printed in cell R18) | Author-reported evaluation · Source checkedMethods, coverage and sourceSPOT-MAS tissue of origin, RF (validation) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-validation Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S18; Validation block; row 'Lung'; column 'RF' under 'Non-metastasis with unknown stage' (n in R18) |
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