Evaluation

SPOT-MAS tissue of origin, RF (discovery)

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Release 2026-10-09-8cc1db47c7f9 · Evidence verified: Not verified

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Evaluation results

1 evaluation · 22 results. Different protocols are not a single leaderboard.

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Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.49 accuracy fraction · higher Uncertainty: Not reported by the source Coverage: 499 cancer patients scored (n printed in cell B10)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C10; Discovery block; row 'All cancer'; column 'RF' under 'All stage' (n in B10)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.82 recall fraction · higher Uncertainty: Not reported by the source Coverage: 156 cancer patients scored (n printed in cell B5)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C5; Discovery block; row 'Breast'; column 'RF' under 'All stage' (n in B5)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.28 recall fraction · higher Uncertainty: Not reported by the source Coverage: 106 cancer patients scored (n printed in cell B6)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C6; Discovery block; row 'CRC'; column 'RF' under 'All stage' (n in B6)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.27 recall fraction · higher Uncertainty: Not reported by the source Coverage: 11 cancer patients scored (n printed in cell F6)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G6; Discovery block; row 'CRC'; column 'RF' under 'Stage I' (n in F6)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.341 recall fraction · higher Uncertainty: Not reported by the source Coverage: 41 cancer patients scored (n printed in cell J6)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K6; Discovery block; row 'CRC'; column 'RF' under 'Stage II' (n in J6)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.27 recall fraction · higher Uncertainty: Not reported by the source Coverage: 41 cancer patients scored (n printed in cell N6)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O6; Discovery block; row 'CRC'; column 'RF' under 'Stage III' (n in N6)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.15 recall fraction · higher Uncertainty: Not reported by the source Coverage: 13 cancer patients scored (n printed in cell R6)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S6; Discovery block; row 'CRC'; column 'RF' under 'Non-metastasis with unknown stage' (n in R6)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.18 recall fraction · higher Uncertainty: Not reported by the source Coverage: 67 cancer patients scored (n printed in cell B7)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C7; Discovery block; row 'Gastric'; column 'RF' under 'All stage' (n in B7)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0 recall fraction · higher Uncertainty: Not reported by the source Coverage: 4 cancer patients scored (n printed in cell F7)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G7; Discovery block; row 'Gastric'; column 'RF' under 'Stage I' (n in F7)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.333 recall fraction · higher Uncertainty: Not reported by the source Coverage: 12 cancer patients scored (n printed in cell J7)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K7; Discovery block; row 'Gastric'; column 'RF' under 'Stage II' (n in J7)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.26 recall fraction · higher Uncertainty: Not reported by the source Coverage: 23 cancer patients scored (n printed in cell N7)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O7; Discovery block; row 'Gastric'; column 'RF' under 'Stage III' (n in N7)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.07 recall fraction · higher Uncertainty: Not reported by the source Coverage: 28 cancer patients scored (n printed in cell R7)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S7; Discovery block; row 'Gastric'; column 'RF' under 'Non-metastasis with unknown stage' (n in R7)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.53 recall fraction · higher Uncertainty: Not reported by the source Coverage: 77 cancer patients scored (n printed in cell B8)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C8; Discovery block; row 'Liver'; column 'RF' under 'All stage' (n in B8)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.75 recall fraction · higher Uncertainty: Not reported by the source Coverage: 4 cancer patients scored (n printed in cell F8)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G8; Discovery block; row 'Liver'; column 'RF' under 'Stage I' (n in F8)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.524 recall fraction · higher Uncertainty: Not reported by the source Coverage: 21 cancer patients scored (n printed in cell J8)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K8; Discovery block; row 'Liver'; column 'RF' under 'Stage II' (n in J8)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.83 recall fraction · higher Uncertainty: Not reported by the source Coverage: 12 cancer patients scored (n printed in cell N8)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O8; Discovery block; row 'Liver'; column 'RF' under 'Stage III' (n in N8)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.43 recall fraction · higher Uncertainty: Not reported by the source Coverage: 40 cancer patients scored (n printed in cell R8)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S8; Discovery block; row 'Liver'; column 'RF' under 'Non-metastasis with unknown stage' (n in R8)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.37 recall fraction · higher Uncertainty: Not reported by the source Coverage: 93 cancer patients scored (n printed in cell B9)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', C9; Discovery block; row 'Lung'; column 'RF' under 'All stage' (n in B9)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.5 recall fraction · higher Uncertainty: Not reported by the source Coverage: 2 cancer patients scored (n printed in cell F9)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', G9; Discovery block; row 'Lung'; column 'RF' under 'Stage I' (n in F9)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.182 recall fraction · higher Uncertainty: Not reported by the source Coverage: 11 cancer patients scored (n printed in cell J9)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', K9; Discovery block; row 'Lung'; column 'RF' under 'Stage II' (n in J9)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.34 recall fraction · higher Uncertainty: Not reported by the source Coverage: 47 cancer patients scored (n printed in cell N9)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', O9; Discovery block; row 'Lung'; column 'RF' under 'Stage III' (n in N9)
Configuration: SPOT-MAS tissue-of-origin Random forest (RF)	Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)	0.45 recall fraction · higher Uncertainty: Not reported by the source Coverage: 33 cancer patients scored (n printed in cell R9)	Author-reported evaluation · Source checked Methods, coverage and source SPOT-MAS tissue of origin, RF (discovery) ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv Aggregation: Not reported Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization; Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Supplementary file 1, sheet 'Table S9', S9; Discovery block; row 'Lung'; column 'RF' under 'Non-metastasis with unknown stage' (n in R9)

Source checking is not independent reproduction. Release 2026-10-09-8cc1db47c7f9.

Evaluation procedure

ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv

Configuration: SPOT-MAS tissue-of-origin Random forest (RF)
Protocol: SPOT-MAS five-class tissue of origin, discovery cohort 10-fold cross-validation
Dataset: SPOT-MAS discovery cohort, 499 non-metastatic cancer patients (five cancer types)

origin: Author-reported evaluation
configuration: Primary source as retrieved 2026-10-09
protocol id: ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv
dataset version: eLife 12:RP89083
split: 10-fold cross-validation
population: 499 cancer patients, five types
inputs: Nine concatenated SPOT-MAS cfDNA feature sets
adaptation: Not reported
metric implementation: Correctly assigned patients / patients in the stratum
aggregation: Per cancer type and stage stratum
budget: Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split: 10-fold cross-validation
Adaptation: Not reported
Scoring implementation: Correctly assigned patients / patients in the stratum

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-8cc1db47c7f9
Property and statement	Original source and location	Review and provenance
attributes.comparison.adaptation Not reported Context-only references	Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML Retrieved: 2026-10-09T20:04:09Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `e09cfb58a6055e89ffa7b553a37539e1687f0fcb26970b7b25eb9eda8e09cfa8` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.adaptation Not reported Context-only references	Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1 Retrieved: 2026-10-09T20:03:58Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.adaptation` Source artifact SHA-256: `4797d7ea0fde127bfa54cf0bdf717d859092c0442ab996a0af10cc5ce17b7331` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Per cancer type and stage stratum Context-only references	Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML Retrieved: 2026-10-09T20:04:09Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `e09cfb58a6055e89ffa7b553a37539e1687f0fcb26970b7b25eb9eda8e09cfa8` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.aggregation Per cancer type and stage stratum Context-only references	Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1 Retrieved: 2026-10-09T20:03:58Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.aggregation` Source artifact SHA-256: `4797d7ea0fde127bfa54cf0bdf717d859092c0442ab996a0af10cc5ce17b7331` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML Retrieved: 2026-10-09T20:04:09Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `e09cfb58a6055e89ffa7b553a37539e1687f0fcb26970b7b25eb9eda8e09cfa8` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.budget Not reported Context-only references	Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1 Retrieved: 2026-10-09T20:03:58Z	missing or unspecified No individual claim review recorded author reported Audit details Field: `attributes.comparison.budget` Source artifact SHA-256: `4797d7ea0fde127bfa54cf0bdf717d859092c0442ab996a0af10cc5ce17b7331` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version eLife 12:RP89083 Context-only references	Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML Retrieved: 2026-10-09T20:04:09Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `e09cfb58a6055e89ffa7b553a37539e1687f0fcb26970b7b25eb9eda8e09cfa8` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.dataset_version eLife 12:RP89083 Context-only references	Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1 Retrieved: 2026-10-09T20:03:58Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.dataset_version` Source artifact SHA-256: `4797d7ea0fde127bfa54cf0bdf717d859092c0442ab996a0af10cc5ce17b7331` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs Nine concatenated SPOT-MAS cfDNA feature sets Context-only references	Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML Retrieved: 2026-10-09T20:04:09Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `e09cfb58a6055e89ffa7b553a37539e1687f0fcb26970b7b25eb9eda8e09cfa8` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
attributes.comparison.inputs Nine concatenated SPOT-MAS cfDNA feature sets Context-only references	Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) Original source ↗ Supplementary file 1 Table S9, RF columns, rows 5-10 Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1 Retrieved: 2026-10-09T20:03:58Z	not individually reviewed No individual claim review recorded author reported Audit details Field: `attributes.comparison.inputs` Source artifact SHA-256: `4797d7ea0fde127bfa54cf0bdf717d859092c0442ab996a0af10cc5ce17b7331` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-10-09-8cc1db47c7f9 · Record review: source checked

2 source records and release history

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization · Original source · eLife 12:RP89083, version of record published 2023-10-11; PMC10567114 full-text XML
Nguyen et al. 2023, Supplementary file 1 (Tables S1-S11) · Original source · Supplementary file 1 (elife-89083-supp1.xlsx) of eLife 12:RP89083, PMC open-access copy PMC10567114.1

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Technical metadata and extraction receipts

Stable ID: ctdnameth-20261009-eval-nguyen2023-spotmas-too-rf-discovery

areas: dna-genomes
contexts: clinical_research
origin: author_reported
protocol: ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv
version: Primary source as retrieved 2026-10-09
comparison: protocol id: ctdnameth-20261009-protocol-nguyen2023-spotmas-too-discovery-cv; dataset version: eLife 12:RP89083; split: 10-fold cross-validation; population: 499 cancer patients, five types; inputs: Nine concatenated SPOT-MAS cfDNA feature sets; adaptation: Not reported; metric implementation: Correctly assigned patients / patients in the stratum; aggregation: Per cancer type and stage stratum; budget: Not reported
source locator: Supplementary file 1 Table S9, RF columns, rows 5-10

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