| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.577 accuracy fraction · higher Uncertainty: 95% CI 0.570965637182417 to 0.583467233499126. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 2 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_acc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.68 auprc unitless · higher Uncertainty: 95% CI 0.673138229330304 to 0.686349543827658. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 6 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_auprc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.603 auroc unitless · higher Uncertainty: 95% CI 0.59498776753148 to 0.61061019851054. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 7 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_auroc'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.631 f1-score fraction · higher Uncertainty: 95% CI 0.624472218706974 to 0.638349991217691. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 8 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_f1'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.69 precision fraction · higher Uncertainty: 95% CI 0.682644786177829 to 0.697670464141102. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 12 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_ppv'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.0577 sensitivity-at-95-percent-specificity fraction · higher Uncertainty: 95% CI 0.0512774353857069 to 0.0646802101303734. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 13 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_sen_95spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.022 sensitivity-at-98-percent-specificity fraction · higher Uncertainty: 95% CI 0.0143570292011298 to 0.0302597450041764. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 14 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_sen_98spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.00446 sensitivity-at-99-percent-specificity fraction · higher Uncertainty: 95% CI 0.00111630321910695 to 0.00855539598159421. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 15 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_sen_99spe'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.583 recall fraction · higher Uncertainty: 95% CI 0.574486770777406 to 0.592487671426348. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 16 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_sensitivity'), column D 'mean' |
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| Configuration: ichorCNA tumour fraction with logistic regression (ichorCNA-TF, Wang et al. 2026) | Protocol: UNITE cross-validation, cancers with ichorCNA tumour fraction 0 to 0.03 vs healthy (Wang et al. 2026) Dataset: UNITE cross-validation set: shallow WGS plasma cfDNA, 458 healthy and 1,232 cancer samples | 0.568 specificity fraction · higher Uncertainty: 95% CI 0.555587925091322 to 0.579672204378448. Interval over the 50 outer test folds as printed in columns G and H Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceichorCNA-TF logistic regression, ichorCNA tumour fraction 0 to 0.03 ctdnafrag-20261009-protocol-wang2026-unite-cv-tf-0-3pct Aggregation: Not reported A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing; Wang et al. 2026, Data file S2 (model scores and summary statistics) · Data file S2 sheet STATS_lr, row 17 (feat 'TF', ichorcna_strat '[0, 0.03]', .metric 'test_specificity'), column D 'mean' |
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