rewirebio.iobenchmarks
Evaluation

OCF (open chromatin), Jiang cohort liver cancer cross-validation

Published comparison; transcribed, not reproduced.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-09-ba02f2f4a36e · Evidence verified: Not verified

Evidence incomplete

Replay metrics

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Verified: Not verified

Evidence incomplete

Investigate discrepancies

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Missing or unresolved evidence

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  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

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Run locally

A pinned recipe describes the inputs, environment and resource requirements.

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Validate independently

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Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: Orientation-aware cell-free fragmentation (OCF), open chromatin regions, SVM (Hou et al. 2024)Protocol: Hou et al. 2024 Jiang cohort cross-validation, liver cancer (Table S2)
Dataset: Jiang et al. 2018 plasma WGS, 90 liver cancer and 135 non-cancer (as used by Hou et al. 2024)
0.939 auroc
unitless · higher

Uncertainty: 95% CI 0.9279 to 0.9493

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

OCF (open chromatin), Jiang cohort liver cancer cross-validation

ctdnafrag-20261009-protocol-hou2024-jiang-lihc-cv-sensitivity

Aggregation: Not reported

Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns; Hou et al. 2024, Supporting Information workbook (Tables S1-S15) · Supporting Information sheet S2, C89; group 'LIHC'; row 'OCF'; column 'AUC'

Source checking is not independent reproduction. Release 2026-10-09-ba02f2f4a36e.

Evaluation procedure

ctdnafrag-20261009-protocol-hou2024-jiang-lihc-cv-sensitivity

Configuration
Orientation-aware cell-free fragmentation (OCF), open chromatin regions, SVM (Hou et al. 2024)
Protocol
Hou et al. 2024 Jiang cohort cross-validation, liver cancer (Table S2)
Dataset
Jiang et al. 2018 plasma WGS, 90 liver cancer and 135 non-cancer (as used by Hou et al. 2024)
origin
Independent external evaluation
configuration
Primary source as retrieved 2026-10-09
protocol id
ctdnafrag-20261009-protocol-hou2024-jiang-lihc-cv-sensitivity
dataset version
Jiang et al. 2018 cohort, fragment files from FinaleDB
split
10 repeats of 10-fold cross-validation
population
90 liver cancer patients vs non-cancer controls of the Jiang et al. cohort
inputs
OCF features in open chromatin regions
adaptation
SVM trained per fold
metric implementation
Not reported
aggregation
Mean with 95% CI
budget
Not reported

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
10 repeats of 10-fold cross-validation
Adaptation
SVM trained per fold
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

36 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
SVM trained per fold
Context-only references
Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.adaptation
SVM trained per fold
Context-only references
Hou et al. 2024, Supporting Information workbook (Tables S1-S15)

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Retrieved: 2026-10-09T20:20:39Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean with 95% CI
Context-only references
Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean with 95% CI
Context-only references
Hou et al. 2024, Supporting Information workbook (Tables S1-S15)

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Retrieved: 2026-10-09T20:20:39Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Retrieved: 2026-10-09T20:27:02Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
Hou et al. 2024, Supporting Information workbook (Tables S1-S15)

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Retrieved: 2026-10-09T20:20:39Z

missing or unspecified

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Jiang et al. 2018 cohort, fragment files from FinaleDB
Context-only references
Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
Jiang et al. 2018 cohort, fragment files from FinaleDB
Context-only references
Hou et al. 2024, Supporting Information workbook (Tables S1-S15)

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Retrieved: 2026-10-09T20:20:39Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
OCF features in open chromatin regions
Context-only references
Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML
Retrieved: 2026-10-09T20:27:02Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
OCF features in open chromatin regions
Context-only references
Hou et al. 2024, Supporting Information workbook (Tables S1-S15)

Original source ↗

Supporting Information Table S2, row 89

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: ADVS-11-2308243-s001.xlsx, PMC open-access copy PMC11321639.1
Retrieved: 2026-10-09T20:20:39Z

not individually reviewed

No individual claim review recorded

independent paper

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 41b24f7e6bcb9bea6127a249127a4c4d53e8ea42b50e95242054791511695fb0

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

2 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: ctdnafrag-20261009-eval-hou2024-s2-ocf-jiang-lihc

areas
dna-genomes
contexts
clinical_research
origin
independent_paper
protocol
ctdnafrag-20261009-protocol-hou2024-jiang-lihc-cv-sensitivity
version
Primary source as retrieved 2026-10-09
comparison
protocol id: ctdnafrag-20261009-protocol-hou2024-jiang-lihc-cv-sensitivity; dataset version: Jiang et al. 2018 cohort, fragment files from FinaleDB; split: 10 repeats of 10-fold cross-validation; population: 90 liver cancer patients vs non-cancer controls of the Jiang et al. cohort; inputs: OCF features in open chromatin regions; adaptation: SVM trained per fold; metric implementation: Not reported; aggregation: Mean with 95% CI; budget: Not reported
source locator
Supporting Information Table S2, row 89
missing metadata
comparison.metric implementation: reason: unreported
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