rewirebio.iobenchmarks
Evaluation

cfMethyl-Seq all-stage cancer detection

Scoped author-reported evidence candidate; no clinical recommendation.

Research readiness

These checks assess whether the evidence supports a reproducible investigation. A source-checked score alone does not meet these requirements.

Release 2026-10-07-1448159e6a81 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • metric replay: verification is missing
  • annotations: verification is missing
  • dependence: verification is missing

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • recipe pinned: verification is missing
  • resource estimate: verification is missing

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • artifact hashes: verification is missing
  • join integrity: verification is missing
  • score semantics: verification is missing
  • independent validation: verification is missing
  • overlap checked: verification is missing

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Read reviewed discrepancy investigations

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: cfMethyl-Seq stacked ensemble (2022)Protocol: cfMethyl-Seq random-split four-cancer detection
Dataset: cfMethyl-Seq 408 QC-passing plasma samples
80.7% sensitivity_at_97_9_percent_specificity
percent · higher

Uncertainty: 95% CI 68.6%–90.7%

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

cfMethyl-Seq all-stage cancer detection

amp-protocol-cfmethyl-randomsplit-detection

Aggregation: Not reported

cfMethyl-Seq cancer detection primary paper · PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

Evaluation procedure

amp-protocol-cfmethyl-randomsplit-detection

Configuration
cfMethyl-Seq stacked ensemble (2022)
Protocol
cfMethyl-Seq random-split four-cancer detection
Dataset
cfMethyl-Seq 408 QC-passing plasma samples
origin
Author-reported evaluation
configuration
Primary source as retrieved 2026-10-07
adaptation
Not reported
aggregation
Mean across10 random splits
budget
Not reported
dataset version
2022 paper cohort
inputs
Plasma cfMethyl-Seq methylation markers
metric implementation
Not reported
population
217 cancers /191 noncancers total; held-out repeated25% splits; test Fig3c n102
protocol id
amp-protocol-cfmethyl-randomsplit-detection
split
10 repeated random 75:25 train/test splits

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
10 repeated random 75:25 train/test splits
Adaptation
Not reported
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

19 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
Property and statementOriginal source and locationReview and provenance
attributes.comparison.adaptation
Not reported
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.aggregation
Mean across10 random splits
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.budget
Not reported
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.dataset_version
2022 paper cohort
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.inputs
Plasma cfMethyl-Seq methylation markers
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.metric_implementation
Not reported
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.population
217 cancers /191 noncancers total; held-out repeated25% splits; test Fig3c n102
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.protocol_id
amp-protocol-cfmethyl-randomsplit-detection
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.comparison.split
10 repeated random 75:25 train/test splits
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

attributes.origin
author_reported
Context-only references
cfMethyl-Seq cancer detection primary paper

Original source ↗

PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37

Version: 2022 version of record, corrected competing-interest disclosure in 2024
Retrieved: 2026-10-07T12:24:42.995810+00:00

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: 6b299962d4cb5684ef98e7f765df16eb19c7833eca66fc5b0cbdc6aa9be29eca

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-10-07-1448159e6a81 · Record review: source checked

1 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: amp-eval-cfmethyl-allstage-sensitivity

areas
dna-genomes
contexts
clinical_research
comparison
adaptation: Not reported; aggregation: Mean across10 random splits; budget: Not reported; dataset version: 2022 paper cohort; inputs: Plasma cfMethyl-Seq methylation markers; metric implementation: Not reported; population: 217 cancers /191 noncancers total; held-out repeated25% splits; test Fig3c n102; protocol id: amp-protocol-cfmethyl-randomsplit-detection; split: 10 repeated random 75:25 train/test splits
missing metadata
integer test denominators: Not inferred from rounded split fractions; metric implementation: Author-reported sensitivity, no executable metric version extracted; seed: Unreported
origin
author_reported
protocol
amp-protocol-cfmethyl-randomsplit-detection
published score reproduction
false
review
method: automated_source_review; notes: Direct primary-text and OOXML cell inspection. Candidate curation pending parent review; no execution, reproduction or qualified human scientific review.; reviewed at: 2026-10-07T12:28:51.639798+00:00; reviewer: Codex AMP methylation/CNV/operations evidence worker
source locator
PMC9522828 XML Par17, Results Cancer detection, Fig3a; split Par16; configuration Par37
version
Primary source as retrieved 2026-10-07
Related records

Suggest a correction