rewirebio.iobenchmarks
Evaluation

AVI AlphaGenome (Retrained) on SGE (AlphaGenome Atlas Table S2)

Developer-reported comparison transcribed from the pinned source; not reproduced.

Evaluation results

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: AVI ablation 'AlphaGenome' (Retrained, AlphaGenome Atlas Table S2)Protocol: AVI feature ablation, SGE column, AUPRC (AlphaGenome Atlas Table S2)
Dataset: Saturation genome editing screens of 13 genes from 14 studies (AlphaGenome Atlas)
-8.29% AUPRC relative difference (ablation 'AlphaGenome' (Retrained) relative to the AVI baseline row, SGE column)
percent · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

AVI AlphaGenome (Retrained) on SGE (AlphaGenome Atlas Table S2)

ag-atlas-20261019-protocol-table-s2-sge

Aggregation: Not reported

AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026) · Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-11-02-a7f03c9e55a5 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Evaluation procedure

AVI feature ablation, SGE column, AUPRC (AlphaGenome Atlas Table S2)

Configuration
AVI ablation 'AlphaGenome' (Retrained, AlphaGenome Atlas Table S2)
Protocol
AVI feature ablation, SGE column, AUPRC (AlphaGenome Atlas Table S2)
Dataset
Saturation genome editing screens of 13 genes from 14 studies (AlphaGenome Atlas)
origin
Author-reported evaluation
configuration
medRxiv v1, retrieved 2026-10-19
dataset version
Not reported
split
Not reported
population
Not reported
inputs
AVI feature vector with the stated features zeroed
adaptation
Retrained
metric implementation
Percentage difference in AUPRC relative to the AVI baseline row
aggregation
Not reported
budget
Not reported
protocol id
ag-atlas-20261019-protocol-table-s2-sge

Metadata review: source checked. Unreported conditions prevent automatic comparisons.

Reproduction

Split
Not reported
Adaptation
Retrained
Scoring implementation
Percentage difference in AUPRC relative to the AVI baseline row

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

18 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statementOriginal source and locationReview and provenance
Comparison: adaptation
Retrained
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.adaptation

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: aggregation
Not reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.aggregation

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: budget
Not reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.budget

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: dataset version
Not reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.dataset_version

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: inputs
AVI feature vector with the stated features zeroed
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.inputs

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: metric implementation
Percentage difference in AUPRC relative to the AVI baseline row
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.metric_implementation

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: population
Not reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.population

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: protocol id
ag-atlas-20261019-protocol-table-s2-sge
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.protocol_id

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Comparison: split
Not reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

missing or unspecified

No individual claim review recorded

author reported

Audit details

Field: attributes.comparison.split

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

Origin
author_reported
Context-only references
AlphaGenome Atlas: in silico mutagenesis of the entire human genome (Cheng, Taylor, Nicolaisen et al., medRxiv 2026)

Original source ↗

Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'

Version: medRxiv preprint version 1, posted 2026-09-20; full-text PDF with supplementary figures and tables (83 pages)
Retrieved: 2026-10-19T12:19:03Z

not individually reviewed

No individual claim review recorded

author reported

Audit details

Field: attributes.origin

Source artifact SHA-256: b32d1539005ca4ea31c3dcef49b834424b1d8b5da4ce6b9fc3e1f942d39fc453

Hash scope: SHA-256 of one retrieval of the medRxiv PDF. A second retrieval at 2026-10-19T12:30:54Z had the same length (15,415,633 bytes) and the same SHA-256.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: ag-atlas-20261019-eval-table-s2-retrained-no-alphagenome-sge

areas
dna-genomes
contexts
clinical_research
origin
author_reported
protocol
ag-atlas-20261019-protocol-table-s2-sge
version
medRxiv v1, retrieved 2026-10-19
comparison
dataset version: Not reported; split: Not reported; population: Not reported; inputs: AVI feature vector with the stated features zeroed; adaptation: Retrained; metric implementation: Percentage difference in AUPRC relative to the AVI baseline row; aggregation: Not reported; budget: Not reported; protocol id: ag-atlas-20261019-protocol-table-s2-sge
source locator
Table S2 (page 70), section 'Retrained', row 'AlphaGenome', column 'SGE'
missing metadata
comparison.aggregation: reason: unreported; comparison.budget: reason: inapplicable; note: No search budget on the benchmark.; comparison.dataset version: reason: unreported; comparison.population: reason: unreported; comparison.split: reason: unreported
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