59,153 propensity-matched perturbation-gene pairs (26.5% positive) from the K562 CRISPRi incremental-value dataset.
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Gene-level logistic regression plus attention edge (Kendiukhov 2026) | Protocol: Gene-level logistic regression under 5-fold GroupKFold by perturbation (Kendiukhov 2026) Dataset subset: Replogle CRISPRi K562, propensity-matched pairs (Kendiukhov 2026) | −0.000 AUROC difference (Gene-level features plus attention edge minus gene-level features only (logistic regression); AUROC over propensity-matched perturbation-gene pairs (k = 5 negatives per positive)) unitless · higher Uncertainty: 95% CI -0.000 to 0.000. Interval type printed as '95% CI' without naming bootstrap; Methods 'Statistical framework': bootstrap CIs use 200 iterations with perturbation-level resampling unless otherwise noted Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourcegfm-guides-20261014-kendiukhov2026-protocol-incremental-value-lr Aggregation: Not reported Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) · Page 9, paragraph 1 (continuing 'No incremental pairwise value'), sentence 3: 'add zero incremental value over gene-level features (∆AUROC = −0.000; 95% CI: [−0.000, +0.000]' |
| Configuration: Geneformer V2-316M attention edges, layer not stated (Kendiukhov 2026) | Protocol: Propensity-matched edge AUROC (Kendiukhov 2026) Dataset subset: Replogle CRISPRi K562, propensity-matched pairs (Kendiukhov 2026) | 0.609 AUROC (AUROC over propensity-matched perturbation-gene pairs (k = 5 negatives per positive)) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourcegfm-guides-20261014-kendiukhov2026-protocol-propensity-matched Aggregation: Not reported Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) · Page 9, paragraph 1 (continuing 'No incremental pairwise value'), sentence 3: 'retain modest raw discriminability (AUROC = 0.609)' |
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6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Scored count 59153 Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source dataset label Replogle genome-scale CRISPRi (K562), propensity-matched Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Page 9 paragraph 1 Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Split No train/test split for edge AUROC; cross-validation where stated by the protocol Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description 59,153 propensity-matched perturbation-gene pairs (26.5% positive) from the K562 CRISPRi incremental-value dataset. Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Name Replogle CRISPRi K562, propensity-matched pairs (Kendiukhov 2026) Context-only references | Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) Page 9 paragraph 1 Version: Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
Stable ID: gfm-guides-20261014-kendiukhov2026-data-k562-crispri-propensity-matched