The twelve targets BindCraft was benchmarked on: PD-1, PD-L1, IFNAR2, CD45, a soluble claudin-1 analogue, BBF-14, CrSAS-6, Der f7, Der f21, Bet v1, the SpCas9 REC1 domain and CbAgo.
1 evaluation · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BindCraft default settings | Protocol: BindCraft experimental success rate averaged over its 12 benchmark targets Dataset: BindCraft 12-target benchmark set | 46.3% Hit rate (unweighted mean of per-target experimental success rates over 12 targets) percent · higher Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft experimental success rate over its 12 benchmark targets uc-binder-20261022-protocol-bindcraft-mean-success-rate-12-targets Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Introduction, final paragraph: 'The binder affinities lie predominantly in the nanomolar range, with success rates from 10% to 100%, with an average success rate of 46.3%' |
| Configuration: BindCraft default settings | Protocol: BindCraft experimental success rate averaged over its 12 benchmark targets Dataset: BindCraft 12-target benchmark set | 10% to 100% Hit rate (range of per-target experimental success rates over 12 targets) percent · higher Uncertainty: Not applicable: The value is itself a range over targets, not an estimate with an interval. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft experimental success rate over its 12 benchmark targets uc-binder-20261022-protocol-bindcraft-mean-success-rate-12-targets Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Introduction, final paragraph: 'with success rates from 10% to 100%' |
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16 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Population Twelve targets chosen by the authors, spanning cell-surface receptors, a membrane-protein soluble analogue, a de novo designed beta barrel, three allergens and two nucleic-acid-guided nucleases. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Population Twelve targets chosen by the authors, spanning cell-surface receptors, a membrane-protein soluble analogue, a de novo designed beta barrel, three allergens and two nucleic-acid-guided nucleases. Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Reported name 12 targets Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Reported name 12 targets Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Scope note Supplementary Table 1 lists fourteen rows; the two AAV rows (HER2 (AAV) and PD-L1 (AAV)) belong to the AAV retargeting application, not the 12-target benchmark. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope note Supplementary Table 1 lists fourteen rows; the two AAV rows (HER2 (AAV) and PD-L1 (AAV)) belong to the AAV retargeting application, not the 12-target benchmark. Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Source location Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Total targets 12 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Total targets 12 Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Results 'Accurate design of de novo binders': 'We benchmarked BindCraft on 12 targets to assess its generalizability (Fig. 1b)' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-data-bindcraft-twelve-benchmark-targets