Programmed death-ligand 1, used as the BindCraft design target with the input structure, hotspot settings and binder length given in Supplementary Table 1.
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BindCraft default settings | Protocol: BindCraft per-target binding screen, hit where a binding signal was observed Dataset: BindCraft binder design target PD-L1 | seven showed a binding signal Count (designs with an observed binding signal (SPR prescreen at 10 micromolar against immobilised PD-L1-Fc, then SPR titration), out of designs tested) count · higher Uncertainty: Not applicable: An exact count. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft binding screen against PD-L1 uc-binder-20261022-protocol-bindcraft-binding-screen Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', paragraph 3: 'We tested nine designs against PD-L1 out of which seven showed a binding signal (Supplementary Fig. 3a)' |
| Configuration: BindCraft default settings | Protocol: BindCraft best per-target binder affinity Dataset: BindCraft binder design target PD-L1 | 615 nM Dissociation constant (binder4; apparent KD (Kd*) by SPR) nanomolar · lower Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft best binder affinity against PD-L1 uc-binder-20261022-protocol-bindcraft-best-affinity Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', paragraph 3: 'The top performing binder4 against PD-L1 showed a Kd* of 615 nM' |
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
14 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Population BindCraft designs generated against PD-L1, 65-155 residues long Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Population BindCraft designs generated against PD-L1, 65-155 residues long Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Reported name PD-L1 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Reported name PD-L1 Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Scope note Supplementary Table 1, row 'PD-L1': input PDB 'AF2 prediction, trimmed to 18-132'; hotspots '54, 56, 66, 115'; binder length '65-155'. In the PDF text layer the superscript reference markers are glued to the accessions and are transcribed as printed. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope note Supplementary Table 1, row 'PD-L1': input PDB 'AF2 prediction, trimmed to 18-132'; hotspots '54, 56, 66, 115'; binder length '65-155'. In the PDF text layer the superscript reference markers are glued to the accessions and are transcribed as printed. Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Source location Supplementary Table 1, row 'PD-L1' Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Supplementary Table 1, row 'PD-L1' Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Version Supplementary Table 1, Nature 2025 version of record Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version Supplementary Table 1, Nature 2025 version of record Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'PD-L1' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-data-bindcraft-pdl1