CD45 extracellular region, four immunoglobulin-like domains with heavy N-glycosylation, used as the BindCraft design target with the input structure, hotspot settings and binder length given in Supplementary Table 1.
2 evaluations · 2 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: BindCraft default settings | Protocol: BindCraft per-target binding screen, hit where a binding signal was observed Dataset: BindCraft binder design target CD45 | 4 showed binding on SPR Count (designs with an observed binding signal (SPR), out of designs tested) count · higher Uncertainty: Not applicable: An exact count. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft binding screen against CD45 uc-binder-20261022-protocol-bindcraft-binding-screen Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', last paragraph: 'We tested 16 binders experimentally, out of which 4 showed binding on SPR (Fig. 1b)' |
| Configuration: BindCraft default settings | Protocol: BindCraft best per-target binder affinity Dataset: BindCraft binder design target CD45 | 14.7 nM Dissociation constant (binder1; by SPR) nanomolar · lower Uncertainty: Not reported by the source: No interval is printed. Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceBindCraft best binder affinity against CD45 uc-binder-20261022-protocol-bindcraft-best-affinity Aggregation: Not reported One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) · Results 'Binders targeting cell-surface receptors', last paragraph: 'The best performing binder1 showed a Kd of 14.7 nM' |
Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.
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Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
14 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Population BindCraft designs generated against CD45, 80-200 residues long Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Population BindCraft designs generated against CD45, 80-200 residues long Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Reported name CD45 Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Reported name CD45 Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Scope note Supplementary Table 1, row 'CD45': input PDB 'AF2 prediction of 5FMV16, split by extracellular fibronectin domains'; hotspots 'd1, d2, d3, d4, d1-d2, d2-d3, d3-d4'; binder length '80-200'. In the PDF text layer the superscript reference markers are glued to the accessions and are transcribed as printed. Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Scope note Supplementary Table 1, row 'CD45': input PDB 'AF2 prediction of 5FMV16, split by extracellular fibronectin domains'; hotspots 'd1, d2, d3, d4, d1-d2, d2-d3, d3-d4'; binder length '80-200'. In the PDF text layer the superscript reference markers are glued to the accessions and are transcribed as printed. Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Source location Supplementary Table 1, row 'CD45' Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Supplementary Table 1, row 'CD45' Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
| Version Supplementary Table 1, Nature 2025 version of record Context-only references | One-shot design of functional protein binders with BindCraft (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Nature, version of record; Europe PMC JATS full text for PMC12507698 | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version Supplementary Table 1, Nature 2025 version of record Context-only references | BindCraft Supplementary Information and Supplementary Data 1 (Pacesa et al., Nature 2025) Supplementary Table 1, row 'CD45' Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: Supplementary files archive for PMC12507698, holding 41586_2025_9429_MOESM1_ESM.pdf (Supplementary Text, Figs. 1-6, Table 1 and References) and 41586_2025_9429_MOESM4_ESM.csv (Supplementary Data 1) | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the whole supplementary archive. Member hashes: Supplementary Information PDF and Supplementary Data 1 CSV were read from this archive without re-download. |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: uc-binder-20261022-data-bindcraft-cd45