rewirebio.iobenchmarks
Dataset

GTEx v8 tissue-specific junction usage differences on held-out chromosomes (Jaganathan et al. 2026)

Anchor-based junction usage from GTEx v8 junction counts summed per tissue, for protein-coding genes (GENCODE v48) on chromosomes 1, 3, 5, 7 and 9; for each junction the 24 highest-usage tissues are paired with the 24 lowest.

Evaluation results

1 evaluation · 3 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: SpliceAI2 tissue-specific fine-tune with a 147-RBP expression signature, 48 GTEx v8 tissues (Jaganathan et al. 2026)Protocol: Tissue-specific junction usage differences across GTEx tissue pairs, held-out chromosomes (SpliceAI2 paper, Pearson)
Dataset: GTEx v8 tissue-specific junction usage differences on held-out chromosomes (Jaganathan et al. 2026)
0.44 Pearson (predicted versus observed logit junction usage difference, all tissue pairs, 14,712,948 comparisons)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

SpliceAI2 tissue-specific fine-tune on GTEx tissue-pair junction usage differences

rna-splicing-20261013-spliceai2-protocol-gtex-tissue-specific

Aggregation: Not reported

A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026) · Main 'Modeling tissue-specific splicing' paragraph 2 '(Pearson r = 0.44; Fig. 2b)'; Fig. 2b panel 'All tissue pairs'
Configuration: SpliceAI2 tissue-specific fine-tune with a 147-RBP expression signature, 48 GTEx v8 tissues (Jaganathan et al. 2026)Protocol: Tissue-specific junction usage differences across GTEx tissue pairs, held-out chromosomes (SpliceAI2 paper, Pearson)
Dataset: GTEx v8 tissue-specific junction usage differences on held-out chromosomes (Jaganathan et al. 2026)
0.58 Pearson (predicted versus observed logit junction usage difference, cerebellum versus blood, 13,770 junctions)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

SpliceAI2 tissue-specific fine-tune on GTEx tissue-pair junction usage differences

rna-splicing-20261013-spliceai2-protocol-gtex-tissue-specific

Aggregation: Not reported

A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026) · Main 'Modeling tissue-specific splicing' paragraph 2 '(13,770 splice junctions, Pearson r = 0.58)'; Fig. 2b panel 'Cerebellum vs blood'
Configuration: SpliceAI2 tissue-specific fine-tune with a 147-RBP expression signature, 48 GTEx v8 tissues (Jaganathan et al. 2026)Protocol: Tissue-specific junction usage differences across GTEx tissue pairs, held-out chromosomes (SpliceAI2 paper, Pearson)
Dataset: GTEx v8 tissue-specific junction usage differences on held-out chromosomes (Jaganathan et al. 2026)
0.51 Pearson (predicted versus observed logit junction usage difference, cortex versus testis, 39,323 junctions)
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

SpliceAI2 tissue-specific fine-tune on GTEx tissue-pair junction usage differences

rna-splicing-20261013-spliceai2-protocol-gtex-tissue-specific

Aggregation: Not reported

A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026) · Main 'Modeling tissue-specific splicing' paragraph 2 '(39,323 splice junctions, Pearson r = 0.51)'; Fig. 2b panel 'Cortex vs testis'

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Metrics are recomputed from the saved predictions: not yet verified
  • Sample annotations are recorded: not yet verified
  • Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • A pinned run recipe exists: not yet verified
  • Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

  • No verified artifact manifest is linked to this exact record.
  • File checksums match the recorded files: not yet verified
  • Predictions are matched to the right samples: not yet verified
  • Score meaning and direction are confirmed: not yet verified
  • Independent validation data exist: not yet verified
  • Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Population
14,712,948 junction-tissue-pair comparisons across all tissue pairs; cerebellum versus blood 13,770 and cortex versus testis 39,323 junctions
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.population

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Reuse restrictions
Controlled access: GTEx individual-level WGS and RNA-seq through dbGaP phs000424.v9.p2. The derived benchmark variant lists are not released with the paper (Data and code availability names only code, weights and precomputed scores).
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.reuse_restrictions

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Source location
Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.source_locator

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Split
Held-out chromosomes 1, 3, 5, 7 and 9
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.split

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Version
GTEx v8 short-read junction counts, 48 tissues
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: attributes.version

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Description
Anchor-based junction usage from GTEx v8 junction counts summed per tissue, for protein-coding genes (GENCODE v48) on chromosomes 1, 3, 5, 7 and 9; for each junction the 24 highest-usage tissues are paired with the 24 lowest.
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: description

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Name
GTEx v8 tissue-specific junction usage differences on held-out chromosomes (Jaganathan et al. 2026)
Context-only references
A unified framework for quantitative splicing and transcript prediction (Jaganathan et al., bioRxiv 2026)

Original source ↗

Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b

Version: bioRxiv preprint version 1, posted 2026-10-11; full-text PDF (57 pages)
Retrieved: 2026-10-13T12:40:34Z

not individually reviewed

No individual claim review recorded

Audit details

Field: name

Source artifact SHA-256: f8f3db2c3943d4827b670bc2e962e0cec8fbe96e0b1acf9d4a9b9f0c7a78c06b

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF. bioRxiv stamps the PDF when serving it (XMP ModifyDate, MetadataDate, DocumentID, InstanceID, Info ModDate and the second trailer ID), so later retrievals differ. A reviewer retrieval on 2026-10-13 of the same length (2,679,664 bytes) had SHA-256 407f5884427dda0226e0ce1f022e4479d3ff2b243da18bcc691eb345b0e04a6a and ModDate D:20261013063115-07'00'; its bytes differ only in those fields and its pdftotext text layer is identical to the pinned copy.

Inspected artifact

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: rna-splicing-20261013-spliceai2-data-gtex-tissue-junctions

areas
rna-transcriptomes
contexts
research
version
GTEx v8 short-read junction counts, 48 tissues
population
14,712,948 junction-tissue-pair comparisons across all tissue pairs; cerebellum versus blood 13,770 and cortex versus testis 39,323 junctions
split
Held-out chromosomes 1, 3, 5, 7 and 9
reuse restrictions
Controlled access: GTEx individual-level WGS and RNA-seq through dbGaP phs000424.v9.p2. The derived benchmark variant lists are not released with the paper (Data and code availability names only code, weights and precomputed scores).
source locator
Main 'Modeling tissue-specific splicing' paragraph 2; Methods 'Prediction of tissue-specific junction usage'; Fig. 2b
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