| Configuration: AlphaFold3 3.0.1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-protein interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.281 DockQ (mean per-interface DockQ, RNA-protein interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAlphaFold3 on RNA complex set, easy and hard combined (RNA-protein) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-protein Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-protein', column 'AF3' |
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| Configuration: AlphaFold3 3.0.1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-RNA interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.406 DockQ (mean per-interface DockQ, RNA-RNA interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceAlphaFold3 on RNA complex set, easy and hard combined (RNA-RNA) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-rna Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-RNA', column 'AF3' |
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| Configuration: Boltz-1 0.4.1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-protein interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.256 DockQ (mean per-interface DockQ, RNA-protein interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBoltz-1 on RNA complex set, easy and hard combined (RNA-protein) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-protein Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-protein', column 'Boltz-1' |
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| Configuration: Boltz-1 0.4.1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-RNA interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.42 DockQ (mean per-interface DockQ, RNA-RNA interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBoltz-1 on RNA complex set, easy and hard combined (RNA-RNA) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-rna Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-RNA', column 'Boltz-1' |
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| Configuration: HelixFold3 HelixFold3/73cd80b-hpc1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-protein interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.075 DockQ (mean per-interface DockQ, RNA-protein interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceHelixFold3 on RNA complex set, easy and hard combined (RNA-protein) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-protein Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-protein', column 'HF3' |
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| Configuration: HelixFold3 HelixFold3/73cd80b-hpc1 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-RNA interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.373 DockQ (mean per-interface DockQ, RNA-RNA interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceHelixFold3 on RNA complex set, easy and hard combined (RNA-RNA) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-rna Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-RNA', column 'HF3' |
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| Configuration: RosettaFoldNA commit f761af2 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-protein interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.039 DockQ (mean per-interface DockQ, RNA-protein interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRosettaFoldNA on RNA complex set, easy and hard combined (RNA-protein) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-protein Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-protein', column 'RF2NA' |
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| Configuration: RosettaFoldNA commit f761af2 (Ludaic and Elofsson 2026 RNA benchmark run) | Protocol: Ludaic and Elofsson 2026 RNA-RNA interfaces, mean per-interface DockQ Dataset: Ludaic and Elofsson 2026 RNA complex set, easy and hard combined | 0.138 DockQ (mean per-interface DockQ, RNA-RNA interfaces) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceRosettaFoldNA on RNA complex set, easy and hard combined (RNA-RNA) lit-rna-20261011-rna3d-protocol-complex-all-if-rna-rna Aggregation: Not reported Limits of deep-learning-based RNA prediction methods: Supplementary Data; Limits of deep-learning-based RNA prediction methods · Supplementary Table S15, row 'RNA-RNA', column 'RF2NA' |
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