AlphaBind antibody variants against antigen PEM, sampled to preserve the affinity distribution, used as the held-out test antigen in the rotation.
4 evaluations · 4 results. Different protocols are not a single leaderboard.
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Boltz-2 (AlphaBind pairwise evaluation) | Protocol: AlphaBind PEM held-out antigen, pairwise accuracy Dataset: AlphaBind PEM antibody variants (held-out antigen) | 57.9% Accuracy (pairwise: stronger binder identified within sampled antibody pairs) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBoltz-2 on AlphaBind PEM (pairwise accuracy) lit-interactions-20261011-mochibind-protocol-alphabind-pem-pairwise-accuracy Aggregation: Not reported A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation · Table 2, row 'PEM', column 'Boltz-2 - iplddt (%)'; STAR Methods, 'Cross-antigen evaluation setup' |
| Configuration: GeoDock (AlphaBind pairwise evaluation) | Protocol: AlphaBind PEM held-out antigen, pairwise accuracy Dataset: AlphaBind PEM antibody variants (held-out antigen) | 47.1% Accuracy (pairwise: stronger binder identified within sampled antibody pairs) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGeoDock on AlphaBind PEM (pairwise accuracy) lit-interactions-20261011-mochibind-protocol-alphabind-pem-pairwise-accuracy Aggregation: Not reported A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation · Table 2, row 'PEM', column 'GeoDock (%)'; STAR Methods, 'Cross-antigen evaluation setup' |
| Configuration: Graphinity (AlphaBind pairwise evaluation) | Protocol: AlphaBind PEM held-out antigen, pairwise accuracy Dataset: AlphaBind PEM antibody variants (held-out antigen) | 63.2% Accuracy (pairwise: stronger binder identified within sampled antibody pairs) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceGraphinity on AlphaBind PEM (pairwise accuracy) lit-interactions-20261011-mochibind-protocol-alphabind-pem-pairwise-accuracy Aggregation: Not reported A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation · Table 2, row 'PEM', column 'Graphinity (%)'; STAR Methods, 'Cross-antigen evaluation setup' |
| Configuration: MochiBind (AlphaBind pairwise evaluation) | Protocol: AlphaBind PEM held-out antigen, pairwise accuracy Dataset: AlphaBind PEM antibody variants (held-out antigen) | 72.35% (p < 0.0001) Accuracy (pairwise: stronger binder identified within sampled antibody pairs) percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceMochiBind on AlphaBind PEM (pairwise accuracy) lit-interactions-20261011-mochibind-protocol-alphabind-pem-pairwise-accuracy Aggregation: Not reported A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation · Table 2, row 'PEM', column 'MochiBind (%)'; STAR Methods, 'Cross-antigen evaluation setup' |
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6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Population 10,000 sampled variants Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location STAR Methods, data sampling and rotation setup Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Split Held-out antigen (rotation: two antigens train, one validation, one test) Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Version AlphaBind dataset as sampled in the MochiBind study Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description AlphaBind antibody variants against antigen PEM, sampled to preserve the affinity distribution, used as the held-out test antigen in the rotation. Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Name AlphaBind PEM antibody variants (held-out antigen) Context-only references | A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation STAR Methods, data sampling and rotation setup Version: iScience 2026, 116522; PMC13444443 full-text XML | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
Stable ID: lit-interactions-20261011-mochibind-data-alphabind-pem