| Configuration: BPNet (large), trained from scratch (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.427 (± 0.025) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.025 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBPNet (large) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'BPNet (large)', column 'H3K4me2'; printed identically in Supplementary Table 7 |
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| Configuration: BPNet (original), trained from scratch (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.427 (± 0.036) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.036 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBPNet (original) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'BPNet (original)', column 'H3K4me2'; printed identically in Supplementary Table 7 |
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| Configuration: BPNet (X-large), trained from scratch (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.341 (± 0.038) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.038 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceBPNet (X-large) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'BPNet (X-large)', column 'H3K4me2'; printed identically in Supplementary Table 7 |
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| Configuration: DNABERT-2, parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.558 (± 0.013) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.013 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceDNABERT-2 on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'DNABERT-2', column 'H3K4me2' |
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| Configuration: Enformer, parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.626 (± 0.015) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.015 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceEnformer on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'Enformer', column 'H3K4me2' |
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| Configuration: HyenaDNA-1KB, parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.521 (± 0.024) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.024 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceHyenaDNA-1KB on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'HyenaDNA-1KB', column 'H3K4me2' |
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| Configuration: HyenaDNA-32KB, parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.515 (± 0.018) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.018 Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceHyenaDNA-32KB on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'HyenaDNA-32KB', column 'H3K4me2' |
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| Configuration: NT-1000G (2.5B), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.569 (± 0.014) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.014 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-1000G (2.5B) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-1000G (2.5B)', column 'H3K4me2' |
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| Configuration: NT-1000G (2.5B), probing (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.531 (± 0.007) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-1000G (2.5B) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'NT-1000G (2.5B)', column 'H3K4me2' |
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| Configuration: NT-1000G (500M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.528 (± 0.011) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.011 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-1000G (500M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-1000G (500M)', column 'H3K4me2' |
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| Configuration: NT-1000G (500M), probing (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.515 (± 0.006) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.006 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-1000G (500M) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'NT-1000G (500M)', column 'H3K4me2' |
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| Configuration: NT 2.5B Randomly Initialized, trained from scratch (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.33 (± 0.014) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.014 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT 2.5B Randomly Initialized on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT 2.5B Randomly Initialized', column 'H3K4me2' |
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| Configuration: NT 500M Randomly Initialized, trained from scratch (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.317 (± 0.021) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.021 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT 500M Randomly Initialized on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT 500M Randomly Initialized', column 'H3K4me2' |
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| Configuration: NT-HumanRef (500M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.527 (± 0.011) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.011 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-HumanRef (500M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-HumanRef (500M)', column 'H3K4me2' |
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| Configuration: NT-HumanRef (500M), probing (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.453 (± 0.01) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-HumanRef (500M) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'NT-HumanRef (500M)', column 'H3K4me2' |
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| Configuration: NT-Multispecies (2.5B), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.552 (± 0.022) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.022 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies (2.5B) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-Multispecies (2.5B)', column 'H3K4me2' |
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| Configuration: NT-Multispecies (2.5B), probing (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.512 (± 0.007) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.007 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies (2.5B) on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'NT-Multispecies (2.5B)', column 'H3K4me2' |
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| Configuration: NT-Multispecies-v2 (100M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.551 (± 0.01) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.01 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies-v2 (100M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-Multispecies-v2 (100M)', column 'H3K4me2' |
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| Configuration: NT-Multispecies-v2 (250M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.57 (± 0.009) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.009 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies-v2 (250M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-Multispecies-v2 (250M)', column 'H3K4me2' |
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| Configuration: NT-Multispecies-v2 (500M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.564 (± 0.012) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.012 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies-v2 (500M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-Multispecies-v2 (500M)', column 'H3K4me2' |
|---|
| Configuration: NT-Multispecies-v2 (50M), parameter-efficient fine-tuning (NT benchmark) | Protocol: NT benchmark H3K4me2, fine-tuning (PEFT) Dataset: NT benchmark H3K4me2 | 0.549 (± 0.014) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.014 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceNT-Multispecies-v2 (50M) on NT benchmark H3K4me2 (fine-tuning) lit-genomics-20261011-ntbench-protocol-h3k4me2-fine-tuning Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 7, row 'NT-Multispecies-v2 (50M)', column 'H3K4me2' |
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| Configuration: Raw Probe, probing of raw sequence (NT benchmark) | Protocol: NT benchmark H3K4me2, probing Dataset: NT benchmark H3K4me2 | 0.36 (± 0.005) MCC (median over 10 cross-validation folds) unitless · higher Uncertainty: SD 0.005 Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceRaw Probe on NT benchmark H3K4me2 (probing) lit-genomics-20261011-ntbench-protocol-h3k4me2-probing Aggregation: Not reported Nucleotide Transformer: Supplementary Information (Supplementary Tables 1-12) · Supplementary Table 6, row 'Raw Probe', column 'H3K4me2'; printed identically in Supplementary Table 7 |
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